上田和雄 (Kazuo UEDA) - マイポータル

基本情報

所属: ノバルティスファーマ株式会社循環器代謝領域メディカルディレクター

学位: 医学博士
Ph.D in Medical Science(Tokyo Medical and Dental University)

J-GLOBAL ID: 200901016839434903
researchmap会員ID: 5000101851

研究キーワード

研究分野

委員歴

Heart Rhythm Society, Industry Member Physician of the Heart Rhythm Society
Japan Surgical Society, Board Certified Surgeon of the Japan Surgical Society
Japanese Circulation Society, Board Certified Member of the Japanese Circulation Society
American Heart Association, International Fellow of the American Heart Association and the Council on Basic Cardiovascular Sciences
American College of Cardiology, International Fellow of the American College of Cardiology

受賞

MISC

GPD1L links redox state to cardiac excitability by PKC-dependent phosphorylation of the sodium channel SCN5A

Carmen R. Valdivia, Kazuo Ueda, Michael J. Ackerman, Jonathan C. Makielski

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 297(4) H1446-H1452 2009年10月
Role of HCN4 channel in preventing ventricular arrhythmia

Kazuo Ueda, Yuji Hirano, Yasushi Higashiuesato, Yoshiyasu Aizawa, Takeharu Hayashi, Natsuko Inagaki, Takeshi Tana, Yusuke Ohya, Shuichi Takishita, Hiromi Muratani …

JOURNAL OF HUMAN GENETICS 54(2) 115-121 2009年2月
Syntrophin mutation associated with long QT syndrome through activation of the nNOS-SCN5A macromolecular complex

Kazuo Ueda, Carmen Valdivia, Argelia Medeiros-Domingo, David J. Tester, Matteo Vatta, Gianrico Farrugia, Michael J. Ackerman, Jonathan C. Makielski

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 105(27) 9355-9360 2008年7月
Molecular and functional characterization of novel glycerol-3-phosphate dehydrogenase 1-like gene (GPD1-L) mutations in sudden infant death syndrome

David W. Van Norstrand, Carmen R. Valdivia, David J. Tester, Kazuo Ueda, Barry London, Jonathan C. Makielski, Michael J. Ackerman

CIRCULATION 116(20) 2253-2259 2007年11月
Anti-KCNH2 antibody-induced long QT syndrome: Novel acquired form of long QT syndrome

Kazufumi Nakamura, Yusuke Katayama, Kengo F. Kusano, Kayo Haraoka, Yoshinori Tani, Satoshi Nagase, Hiroshi Morita, Daiji Miura, Yoshihisa Fujimoto, Tetsushi Furukawa …

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 50(18) 1808-1809 2007年10月
A novel mutation in KCNQ1 associated with a potent dominant negative effect as the basis for the LQT1 form of the long QT syndrome

Yoshiyasu Aizawa, Kazuo Ueda, Fabiana Scornik, Jonathan M. Cordeiro, Yuesheng Wu, Mayurika Desai, Alejandra Guerchicoff, Yasutoshi Nagata, Yoshito Iesaka, Akinori Kimura …

JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY 18(9) 972-977 2007年9月
SCN4B-encoded sodium channel beta 4 subunit in congenital long-QT syndrome

Argelia Medeiros-Domingo, Toshihiko Kaku, David J. Tester, Pedro Iturralde-Torres, Ajit Itty, Bin Ye, Carmen Valdivia, Kazuo Ueda, Samuel Canizales-Quinteros, Maria Teresa Tusie-Luna …

CIRCULATION 116(2) 134-142 2007年7月
A novel mutation in FKBP12.6 binding region of the human cardiac ryanodine receptor gene (R2401H) in a Japanese patient with catecholaminergic polymorphic ventricular tachycardia

Y Aizawa, K Ueda, S Komura, T Washizuka, M Chinushi, N Inagaki, Y Matsumoto, T Hayashi, M Takahashi, N Nakano …

INTERNATIONAL JOURNAL OF CARDIOLOGY 99(2) 343-345 2005年3月
Novel C-terminus frameshift mutation, 1122fs/147, of HERG in LQT2: additional amino acids generated by frameshift cause accelerated inactivation

T Sasano, K Ueda, M Orikabe, Y Hirano, S Kawano, M Yasunami, M Isobe, A Kimura, M Hiraoka

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 37(6) 1205-1211 2004年12月
Tcap gene mutations in hypertrophic cardiomyopathy and dilated cardiomyopathy

T Hayashi, T Arimura, M Itoh-Satoh, K Ueda, S Hohda, N Inagaki, M Takahashi, H Hori, M Yasunami, H Nishi …

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 44(11) 2192-2201 2004年12月
Truncated KCNQ1 mutant, A178fs/105, forms hetero-multimer channel with wild-type causing a dominant-negative suppression due to trafficking defect

Y Aizawa, K Ueda, LM Wu, N Inagaki, T Hayashi, M Takahashi, M Ohta, S Kawano, Y Hirano, M Yasunami …

FEBS LETTERS 574(1-3) 145-150 2004年9月
Functional characterization of a trafficking-defective HCN4 mutation, D553N, associated with cardiac arrhythmia

K Ueda, K Nakamura, T Hayashi, N Inagaki, M Takahashi, T Arimura, H Morita, Y Higashiuesato, Y Hirano, M Yasunami …

JOURNAL OF BIOLOGICAL CHEMISTRY 279(26) 27194-27198 2004年6月
A Cypher/ZASP mutation associated with dilated cardiomyopathy alters the binding affinity to protein kinase C

T Arimura, T Hayashi, H Terada, SY Lee, Q Zhou, M Takahashi, K Ueda, T Nouchi, S Hohda, M Shibutani …

JOURNAL OF BIOLOGICAL CHEMISTRY 279(8) 6746-6752 2004年2月
Identification and functional analysis of a caveolin-3 mutation associated with familial hypertrophic cardiomyopathy

T Hayashi, T Arimura, K Ueda, H Shibata, S Hohda, M Takahashi, H Hori, Y Koga, N Oka, T Imaizumi …

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 313(1) 178-184 2004年1月
Association study of CD14 polymorphism with myocardial infarction in a Japanese population.

Hohda S, Kimura A, Sasaoka T, Hayashi T, Ueda K, Yasunami M, Okabe M, Fukuta N, Kurosawa T, Izumi T

Jpn Heart J. 44(5) 613-622 2003年
Association study of CD14 polymorphism with myocardial infarction in a Japanese population.

Hohda S, Kimura A, Sasaoka T, Hayashi T, Ueda K, Yasunami M, Okabe M, Fukuta N, Kurosawa T, Izumi T

Jpn Heart J. 44(5) 613-622 2003年
Titin mutations as the molecular basis for dilated cardiomyopathy

M Itoh-Satoh, T Hayashi, H Nishi, Y Koga, T Arimura, T Koyanagi, M Takahashi, S Hohda, K Ueda, T Nouchi …

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 291(2) 385-393 2002年2月
A prominent Chiari network.

Tanaka H, Ueda K, Murakami M, Hasegawa S, Sunamori M

Ann Thorac Surg. 73(6) 1985 2002年
Identification of MICA alleles with a long Leu-repeat in the transmembrane region and no cytoplasmic tail due to a frameshift-deletion in exon 4.

Obuchi N, Takahashi M, Nouchi T, Satoh M, Arimura T, Ueda K, Akai J, Ota M, Naruse T, Inoko H …

Tissue Antigens. 57(6) 520-35 2001年
Identification of MICA alleles with a long Leu-repeat in the transmembrane region and no cytoplasmic tail due to a frameshift-deletion in exon 4.

Obuchi N, Takahashi M, Nouchi T, Satoh M, Arimura T, Ueda K, Akai J, Ota M, Naruse T, Inoko H …

Tissue Antigens. 57(6) 520-35 2001年

もっとみる

所属学協会

共同研究・競争的資金等の研究課題

致死性および難治性不整脈の病態機序の解明

その他の研究制度
Molecular pathogenesis of cardiac arrthythmias

The Other Research Programs