Associate Professor, Faculty of Pharmacy, Meijo University
Apr 2017
-
Mar 2018
Visiting Researcher, Department of Women’s and Children’s Health, Clinical Genetics Group (Stephen Robertson’s Lab), University of Otago, Dunedin School of Medicine,
HOKKAIDO UNIVERSITY
Faculty of Advanced Life Science
Laboratory of Proteoglycan Signaling and Therapeutics
Glycobiological approaches for bone and skin disorders caused by deficiency of glycosaminoglycans and its role for tumor metastasis, Research Award for Japanese Society of Carbohydrate Research, The Japanese Society of Carbohydrate Research
Winner: Shuji Mizumoto
Aug 2015
Travel Award, 9th International Conference on Proteoglycans and 10th Pan-Pacific Connective Tissue Societies Symposium
Trends in Glycoscience and Glycotechnology 30(174) E67-E89 May 2018 [Refereed][Invited]
Impaired proteoglycan glycosylation, elevated TGF-β signaling, and abnormal osteoblast differentiation as the basis for bone fragility in a mouse model for gerodermia osteodysplastica
Wing Lee Chan, Magdalena Steiner, Tomasz Witkos, Johannes Egerer, Björn Busse, Shuji Mizumoto, Jan M. Pestka, Haikuo Zhang, Ingrid Hausser, Layal Abo Khayal, Claus-Eric Ott, Mateusz Kolanczyk, Bettina Willie, Thorsten Schinke, Chiara Paganini, Antonio Rossi, Kazuyuki Sugahara, Michael Amling, Petra Knaus, Danny Chan, Martin Lowe, Stefan Mundlos, Uwe Kornak
PLoS Genetics 14(3) e1007242 Mar 2018 [Refereed]
Vascular abnormalities in the placenta of Chst14-/- fetuses: implications in the pathophysiology of perinatal lethality of the murine model and vascular lesions in human CHST14/D4ST1 deficiency
Julia Vodopiutz, Shuji Mizumoto, Ekkehard Lausch, Antonio Rossi, Sheila Unger, Nikolaus Janocha, Rainer Seidl, Susanne Greber-Platzer, Shuhei Yamada, Thomas Müller, Bernd Jilma, Rudolf Ganger, Andrea Superti-Furga, Shiro Ikegawa, Kazuyuki Sugahara, Andreas R. Janecke
*Florian Job, *Shuji Mizumoto, Laurie Smith, Natario Couser, Ashley Brazil, Howard Saal4, Melanie Patterson5, Margaret I. Gibson5, Sarah Soden6, Neil Miller7, Isabelle Thiffault5, Carol Saunders5, Shuhei Yamada, Katrin Hoffmann, Kazuyuki Sugahara, Emily Farrow. (*equal contribution)
*Birgit S. Budde, *Shuji Mizumoto, Ryo Kogawa, Christian Becker, Janine Altmüller, Holger Thiele, Franz Rüschendorf, Mohammad R. Toliat, Gerrit Kaleschke, Johannes M. Hämmerle, Wolffang Höhne, Kazuyuki Sugahara, Peter Nürnberg, Ingo Kennerknecht. (*equal contribution)
*Thomas Müller, *Shuji Mizumoto, *Indrajit Suresh, Yoshie Komatsu, Julia Vodopiutz, Munis Dündar, Volker Straub, Arno Lingenhel, Andreas Melmer, Silvia Lechner, Johannes Zschocke, Kazuyuki Sugahara, Andreas R Janecke (*equal contribution)
Human Molecular Genetics 22(18) 3761-3772 Sep 2013 [Refereed]
Mirjam H.H. van Roij, Shuji Mizumoto, Shuhei Yamada, Tim Morgan, M.B. Tan-Sindhunata, H. Meijers-Heijboer, J.I.L.M. Verbeke, David Markie, Kazuyuki Sugahara, Stephen P. Robertson
American Journal of Medical Genetics 146A(18) 2376-2384 2008
Fuchuan Li, Gerdy B. ten Dam, Sengottuvelan Murugan, Shuhei Yamada, Taishi Hashiguchi, Shuji Mizumoto, Kayoko Oguri, Minoru Okayama|, Toin H. van Kuppevelt, and Kazuyuki Sugahara
Journal of Biological Chemistry 283(49) 34294-34304 2008
Demonstration of the hepatocyte growth factor signaling pathway in the in vitro neuritogenic activity of chondroitin sulfate from ray fish cartilage in press 2011
Sevjidmaa Baasanjav, Lihadh Al-Gazali, Taishi Hashiguchi, Shuji Mizumoto, Bjoern Fischer, Denise Horn, Dominik Seelow, Bassam R. Ali, Samir A.A. Aziz, Ruth Langer, Ahmed A.H. Saleh, Christian Becker, Gudrun Nürnberg, Vincent Cantagre, Joseph G. Gleeson, Delphine Gomez, Jean-Baptiste Michel, Sigmar Stricker, Tom H. Lindner, Peter Nürnberg, Kazuyuki Sugahara, Stefan Mundlos, Katrin Hoffmann
American Journal of Human Genetics 89(1) 15-27 2011
Tomoki Kosho, Shuji Mizumoto, and Kazuyuki Sugahara (Part:Joint Work)
May 2014
ISCSM2011 Chondroitin sulfate E-type structure at tumor cell surface is involved in experimental metastasis
May 2012
Glycosaminoglycan chain analysis and characterization (Glycosylation/Epimerization)
In Methods in Molecular Biology, “Proteoglycans: Methods and Protocols”
Humana Press, Springer, 2011
Biosynthesis and roles in skin of glycosaminoglycans
In Fragrance Journal 2010
Heparan sulfate synthases and related genes
In Experimental Glycoscience “Glycobiology” (Taniguchi N., Suzuki A., Ito Y., Narimatsu H., Kawasaki T., Hase S., eds), pp. 59-63, 2008, Springer, Tokyo, Japan 2008
Heparan sulfate synthase-related genes
Shuji Mizumoto, Hiroshi Kitagawa, and Kazuyuki Sugahara (Part:Joint Work)
Dec 2005
Biosynthetic pathways for differential expression of functional chondroitin sulfate and heparan sulfate
In Handbook of Carbohydrate Engineering (Kevin J. Yarema, ed.), CRC Press (Taylor & Francis Group), pp. 289-324, 2005, Boca Raton, FL. 2005
Biosynthesis of Heparin and Heparan sulfate
In Chemistry and Biology of Heparin and Heparan sulfate (Hari G. Garg, Robert J. Linhardt and Charles A. Hales, eds.), pp. 203-243, 2005, Elsevier, Oxford, UK. 2005
The International Symposium on the Ehlers-Danlos Syndromes 27 Sep 2018
A mouse model for gerodermia osteodysplastica, Gorab-null mice, shows a reduction in glycosaminoglycans
Wing Lee Chan, Magdalena Steiner Tomasz Witkos, Johannes Egerer, Björn Busse, ◯Shuji Mizumoto, Jan M. Pestka, Haikuo Zhang, Ingrid Hausser, Layal Abo Khayal, Claus-Eric Ott, Mateusz Kolanczyk, Bettina Willie, Thorsten Schinke, Chiara Paganini, Antonio Rossi, Kazuyuki Sugahara, Michael Amling, Petra Knaus, Danny Chan, Martin Lowe, Stefan Mundlos, Uwe Kornak
The 91st Annual Meeting of Japanese Biochemical Society 24 Sep 2018
Spondyloepimetaphyseal dysplasia with immune deficiency caused by mutation in EXTL3
◯水本秀二, Long Guo, Nursel H Elcioglu, Zheng Wang, Bilge Noyan, Hatice M Albayrak,松本直通, 三宅紀子, 西村玄, 山田修平, 池川志郎
The 37th Annual Meeting of Japanese Carbohydrate Research 30 Aug 2018
Defects in Biosynthesis of Glycosaminoglycans Cause Hereditary Bone, Skin, Heart, Immune, and Neurological Disorders[Invited]
◯Shuji Mizumoto
National Glycoengineering Research Center (NGRC) Seminar 21 Jun 2018
A novel type of spondylo-epi-metaphyseal dysplasia with immuno-deficiency caused by mutation in EXTL3 encoding a glycosyltransferase responsible for biosynthesis of heparan sulfate
◯Shuji Mizumoto, Long Guo, Nursel H Elcioglu, Zheng Wang, Bilge Noyan, Hatice M Albayrak, Naomichi Matsumoto, Noriko Miyake, Gen Nishimura, Shuhei Yamada, and Shiro Ikegawa
The 11th International Symposium on Glycosyltransferases (GlycoT2018) 19 Jun 2018
Integrated neuroglycobiology for proteoglycans and chondroitin sulfate-binding proteins
◯Shuji Mizumoto, Yusuke Yoshikawa, Shuhei Yamada, Kosei Takeuchi, Yoshiaki Nakayama, Akira Kurosaka, Keiichiro Matsushima, Nobuyuki Miyamoto, Wataru Takada, Hirofumi Kodera, Naomichi Matsumoto, Hirotomo Saitsu, Gunnar Dick, James W. Fawcett, Jessica C. F. Kwok, and Kazuyuki Sugahara
平成28年度 新学術領域「神経糖鎖生物学」最終シンポジウム 3 Mar 2017
Multiple fractures and severe osteoporosis caused by mutations in a glycosyltransferase responsible for biosynthesis of glycosaminoglycans
27 Sep 2016
Quantification of dermatan sulfate from urine in Ehlers-Danlos syndrome caused by carbohydrate sulfotransferase 14 (CHST14)/dermatan 4-O-sulfotransferase-1 (D4ST1) deficiency
XXVIII International Carbohydrate (ICS2016), New Orleans, Loisiana, USA 19 Jul 2016
Multiple fractures and severe osteoporosis caused by mutations in a glycosyltransferase responsible for biosynthesis of glycosaminoglycans
◯S Mizumoto, F Job, L Smith, N Couser, A Brazil, H Saul, M Patterson, MI Gibson, S Soden, N Miller, I Thiffault, C Saunders, S Yamada, K Hoffman, K Sugahara, E Farrow
The 10th International Symposium on Glycosyltransferases (GlycoT2016), Tronto, Canada 20 Jun 2016
Detection of the degradation activities of chondroitin sulfate and hyaluronan in mouse brain as well as cultured cell lines
◯Shuji Mizumoto, Tomomasa Yamanaka, Sae Nagai, and Shuhei Yamada
The 3rd International Symposium on Glyco-Neuroscience, Awaji Yumebutai International Conference Center 14 Jan 2016
Loss-of-function mutation of glucuronyltransferase-I causes skeletal dysplasia in a consanguineous clan from the island of Nias/Indonesia
◯Shuji Mizumoto, Birgit S. Budde, Ryo Kogawa, Christian Becker, Janine Altmüller, Holger Thiele, Franz Rüschendorf, Mohammad R. Toliat, Gerrit Kaleschke, Johannes M. Hämmerle, Wolffang Höhne, Kazuyuki Sugahara, Peter Nürnberg, Ingo Kennerknecht
9th International Conference on Proteoglycans and 10th Pan-Pacific Connective Tissue Societies Symposium, Seoul, Korea, ECC, Ewha Womans University 24 Aug 2015
Spondyloepimetaphyseal dysplasia and Ehlers-Danlos syndrome caused by mutations of glycosaminoglycan biosynthetic enzymes, GalT-II and DS-epimerase
◯Shuji Mizumoto, Masahiro Nakajima, Thomas Müller4 Noriko Miyake, Ryo Kogawa, Yoshie Komatsu, Naomichi Matsumoto, Andreas R Janecke, Shiro Ikegawa, Kazuyuki Sugahara
Joint Meeting of the Society for Glycobiology and the Japanese Society of Carbohydrate Research, Honolulu, Hawaii 19 Nov 2014
A numbers of genetic bone and skin disorders caused by defect in side chains of proteoglycans[Invited]
The 85th Annual Meeting of the Japanese Biochemical Society 15 Dec 2012
Receptor for Advanced Glycation End-products (RAGE) functions as a receptor for glycosaminoglycans involved in pulmonary metastasis
◯Shuji MIZUMOTO, Jun TAKAHASHI, Kazuyuki SUGAHARA
The 10th International Symposium for Future Drug Discovery and Medical Care, Sapporo 3 Oct 2012
RAGE is a functional receptor for chondroitin sulfate involved in pulmonary metastasis of tumor cells
◯Shuji Mizumoto, Jun Takahashi, and Kazuyuki Sugahara
The 31st Japanese Carbohydrate Symposium 20 Sep 2012
Novel highly sulfated hexasaccharide sequences isolated from chondroitin sulfate of shark fin cartilage: Insights into the sugar sequences involved in brain development
meijo-u.ac.jp