Two major phospholipase D (PLD) isozymes in mammals, PLD1 and PLD2, hydrolyze the membrane phospholipid phosphatidylcholine to choline and the lipid messenger phosphatidic acid. Although their roles in cancer cells have been well studied, their fu...
A hallmark of clear cell renal cell carcinoma (ccRCC) is the presence of intracellular lipid droplets (LD) and it is assumed that phosphatidic acid (PA) produced by phospholipase D (PLD) plays some roles in the LD formation. However, little is kno...
Journal of Leukocyte Biology 103(5) 867-883 2018年4月 [査読有り]
The uptake of cholesterol carried by low-density lipoprotein (LDL) is tightly controlled in the body. Macrophages are not well suited to counteract the cellular consequences of excess cholesterol leading to their transformation into "foam cells," ...
Anti-aging effects of black raspberry extract on cataract, alopecia, skin whitening, and weight loss
Dan, Katsuaki; Takada, Atsushi; Kanaho, Yasunori; Kusumi, Yuko; Banno, Harutaka
FUNCTIONAL FOODS IN HEALTH AND DISEASE 8(1) 17-34 2018年1月
HGF and its receptor c-Met are critical molecules in various biological processes. Others and we have previously shown that the small GTPase Arf6 plays a pivotal role in HGF signaling in hepatocytes. However, the molecular mechanism of how Arf6 re...
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