Yusuke Takahashi

Profile Information

Affiliation: Associate Professor, Osaka University Dental Hospital, Osaka University

Degree: PhD(Mar, 2002, Osaka University)

Researcher number: 60397693
ORCID ID: https://orcid.org/0000-0002-7974-1252
J-GLOBAL ID: 200901014876657022
researchmap Member ID: 5000102900

External link: https://www.dent.osaka-u.ac.jp/conserve/conserve-2707

Research Interests

Research Areas

Life sciences / Conservative dentistry and endodontics /

Research History

Apr, 2015 - Present

Associate Professor, Restorative Dentistry and Endodontology, Osaka University Osaka University Dental Hospital
Apr, 2012 - Mar, 2015

Assistant Professor, Osaka University Graduate School of Dentistry Course for Oral Sciences
May, 2010 - Mar, 2015

Osaka University Graduate School of Dentistry Department of Restorative Dentistry and Endodontology, Assistant Professor
Apr, 2007 - Mar, 2012

Assistant Professor, Osaka University Graduate School of Dentistry Course for Molecular Oral Biology and Dentistry
May, 2009 - Apr, 2010

The University of Birmingham School of Dentistry, Department of Oral Biology, Honorary Visiting Research Fellow
Apr, 2007 - Mar, 2009

Assistant Professor
Jan, 2006 - Mar, 2007

Research Assistant, Osaka University Graduate School of Dentistry Course for Molecular Oral Biology and Dentistry
Jan, 2006 - Mar, 2007

大阪大学大学院歯学研究科助手
2007

- 大阪大学大学院歯学研究科助教
Apr, 2005 - Dec, 2005

Specially Appointed Researcher, Osaka University Graduate School of Dentistry Course for Molecular Oral Biology and Dentistry
Apr, 2005 - Dec, 2005

大阪大学大学院歯学研究科特任研究員
Apr, 2002 - Mar, 2005

大阪大学歯学部附属病院・医員

Education

- Mar, 2002

Graduate School, Division of Dental Research, Osaka University
- Mar, 1998

Faculty of Dentistry, Osaka University

Awards

Oct, 2020

Dean Award of Osaka University Graduate School of Dentistry, Osaka University Graduate School of Dentisry

Yusuke Takahashi
Jun, 2020

Osaka University Dental Society Excellent Research Encouragement Award, Lithium-containing surface pre-reacted glass fillers enhance hDPSC functions and induce reparative dentin formation in a rat pulp capping model through activation of Wnt/b-catenin signaling, The Osaka University Dental Society

Manahil Ali, Motoki Okamoto, Shungo Komichi, Masakatsu Watanabe, Hailing Huang, Yusuke Takahashi, Mikako Hayashi
Mar, 2019

平成30年度大阪大学歯学研究科長賞（研究分野）, 大阪大学大学院歯学研究科

高橋雄介
Sep, 2017

日本レーザー歯学会優秀発表賞, 日本レーザー歯学会

岡本基岐
Jul, 2014

大阪大学総長奨励賞, 大阪大学

高橋雄介
Jun, 2014

日本歯科保存学会年間優秀論文賞, 日本歯科保存学会

高橋雄介
Jun, 2005

日本歯科保存学会奨励賞, 日本歯科保存学会

高橋雄介

Papers

Analyzing the anti-caries effect of fluoride varnish containing tricalcium phosphate using PIXE/PIGE

Reo UEMURA, Hiroko YAMAMOTO, Katsuaki NAITO, Hikaru KANDA, Yusuke TAKAHASHI, Mikako HAYASHI

Dental Materials Journal, 42(4) 591-597, Jul 25, 2023 Peer-reviewed
Repair of an Extensive External Cervical Resorption Lesion Using Intentional Replantation with Crown Rotation

Motoki Okamoto, Yoko Asahi, Henry Fergus Duncan, Nanako Kuriki, Yusuke Takahashi, Mikako Hayashi

Case Reports in Dentistry, 2023 1-10, Jun 26, 2023 Peer-reviewed
Case report: Delayed autologous tooth transplantation based on objective bone healing of the extraction socket (4-year follow-up)

Yusuke Takahashi, Shotaro Abe, Motoki Okamoto, Tomomi Tsujimoto, Shumei Murakami, Mikako Hayashi

Frontiers in Dental Medicine, 4, Jun 15, 2023 Peer-reviewedLead authorCorresponding author
骨形成不全症患者の慢性根尖性歯周炎罹患歯に対応した1症例

前薗葉月, 川西雄三, 島岡毅, 高橋雄介, 林美加子

日本歯科保存学雑誌, 66(2) 131-137, Jun, 2023 Peer-reviewed
Development of Rat Caries-Induced Pulpitis Model for Vital Pulp Therapy

H. Huang, M. Okamoto, M. Watanabe, S. Matsumoto, K. Moriyama, S. Komichi, M. Ali, S. Matayoshi, R. Nomura, K. Nakano …

Journal of Dental Research, 102(5) 574-582, May, 2023 Peer-reviewedCorresponding author
Morphological Analyses of Effects of Endodontic Irrigant Solutions Using a Root Canal Model and an Immersion Model.

Yuzo Kawanishi, Hazuki Maezono, Tsuyoshi Shimaoka, Takumi Kitatani, Katsuaki Naito, Maki Sotozono, Kittipit Klanliang, Yusuke Takahashi, Mikako Hayashi

International journal of dentistry, 2023 3938522-3938522, 2023 Peer-reviewedCorresponding author
Novel Functional Peptide for Next-Generation Vital Pulp Therapy

M. Watanabe, M. Okamoto, S. Komichi, H. Huang, S. Matsumoto, K. Moriyama, J. Ohshima, S. Abe, M. Morita, M. Ali …

Journal of Dental Research, 002203452211357-002203452211357, Nov 22, 2022 Peer-reviewedCorresponding author
Biological Evaluation of the Effect of Root Canal Sealers Using a Rat Model

Motoki Okamoto, Sayako Matsumoto, Kiichi Moriyama, Hailing Huang, Masakatsu Watanabe, Jiro Miura, Keita Sugiyama, Yujiro Hirose, Manabu Mizuhira, Nanako Kuriki …

Pharmaceutics, 14(10) 2038-2038, Sep 24, 2022 Peer-reviewed
次世代の歯髄保存療法を目指したペプチド覆髄材

高橋雄介

日本歯科保存学雑誌, 65(2) 115-119, Jun, 2022 InvitedLead authorLast authorCorresponding author
Biological properties of lithium-containing surface pre-reacted glass fillers as direct pulp-capping cements

Manahil Ali, Motoki Okamoto, Masakatsu Watanabe, Hailing Huang, Sayako Matsumoto, Shungo Komichi, Yusuke Takahashi, Mikako Hayashi

Dental Materials, 38(2) 294-308, Feb, 2022 Peer-reviewedCorresponding author
Partial Pulpotomy to Successfully Treat a Caries-Induced Pulpal Micro-Abscess: A Case Report

Okamoto Motoki, Duncan Henry Fergus, Takahashi Yusuke, Kuriki Nanako, Sayako Matsumoto, Hayashi Mikako

Frontiers in Dental Medicine, 2, Jun 22, 2021 Peer-reviewed
A Case Report: Endodontic-periodontal Disease Due to Root Malformation

Motoki OKAMOTO, Yoshifumi KINOMOTO, Nanako KURIKI, Keigo SAWADA, Yusuke TAKAHASHI, Shinya MURAKAMI, Mikako HAYASHI

The Japanese Journal of Conservative Dentistry, 64(2) 171-180, 2021 Peer-reviewed
Evaluation of physical properties of fiber-reinforced composite resin

Naoko Suzaki, Satoshi Yamaguchi, Nanako Hirose, Ryousuke Tanaka, Yusuke Takahashi, Satoshi Imazato, Mikako Hayashi

Dental Materials, 36(8) 987-996, Aug, 2020 Peer-reviewed
Cytotoxicity of S-PRG Fillers: Direct Exposure of Fillers and Eluates from the Fillers to RAW264 Cells

Masanori HASHIMOTO, Haruaki KITAGAWA, Yusuke TAKAHASHI, Mikako HAYASHI, Satoshi IMAZATO

Nano Biomedicine, 12(1) 3-10, Jun, 2020 Peer-reviewed
Performance of a Biodegradable Composite with Hydroxyapatite as a Scaffold in Pulp Tissue Repair

Motoki Okamoto, Sayako Matsumoto, Ayato Sugiyama, Kei Kanie, Masakatsu Watanabe, Hailing Huang, Manahil Ali, Yuki Ito, Jiro Miura, Yujiro Hirose …

Polymers, 12(4) 937-937, Apr 17, 2020 Peer-reviewed
Bonding performance of a newly developed one-step single-bottle adhesive on sound human dentin with different tubule orientations.

Koytchev E, Takahashi Y, Suzaki N, Okamoto M, Hayashi M

Ser Biomecha, 34(1) 3-11, Jan, 2020 Peer-reviewed
Investigation on Effective Education Methods for Preparing Curved-root Canal with FKG Race Part 2. Proficiency of J- and S-shaped Root Canal Preparation by Using Nickel-titanium File FKG Race

OHSHIMA Jun, KAWANISHI Yuzo, OKA Shintaro, YAMADA Tomomi, YAMAGUCHI Mikiyo, ASAHI Yoko, SOTOZONO Maki, KAGIOKA Takumi, WATANABE Masakatsu, NAITO Katsuaki …

Japanese Journal of Conservative Dentistry, 62(6) 263-270, Dec, 2019 Peer-reviewed
Surface Pre-Reacted Glass Filler Contributes to Tertiary Dentin Formation through a Mechanism Different Than That of Hydraulic Calcium-Silicate Cement.

Motoki Okamoto, Manahil Ali, Shungo Komichi, Masakatsu Watanabe, Hailing Huang, Yuki Ito, Jiro Miura, Yujiro Hirose, Manabu Mizuhira, Yusuke Takahashi …

Journal of clinical medicine, 8(9) 1440-1440, Sep 11, 2019 Peer-reviewed
Lithium-containing surface pre-reacted glass fillers enhance hDPSC functions and induce reparative dentin formation in a rat pulp capping model through activation of Wnt/β-catenin signaling.

Manahil Ali, Motoki Okamoto, Shungo Komichi, Masakatsu Watanabe, Hailing Huang, Yusuke Takahashi, Mikako Hayashi

Acta Biomaterialia, 96 594-604, Sep, 2019 Peer-reviewedCorresponding author
Protein S100-A7 Derived from Digested Dentin Is a Critical Molecule for Dentin Pulp Regeneration.

Shungo Komichi, Yusuke Takahashi, Motoki Okamoto, Manahil Ali, Masakatsu Watanabe, Hailing Huang, Takeo Nakai, Paul Cooper, Mikako Hayashi

Cells, 8(9) 1002, Aug, 2019 Peer-reviewed

Misc.

Evaluation of the localization of leptin in a rat caries derived pulpitis model

森山輝一, 岡本基岐, 松本紗也子, 渡邉昌克, HUANG Hailing, 高橋雄介, 林美加子

日本歯科保存学会学術大会プログラムおよび講演抄録集(Web), 156th, 2022
Establishment of novel diagnostic methods for reversible and irreversible pulpitis associated with caries progression using ultra-high magnetic field MRI

森山輝一, 岡本基岐, 松本紗也子, 渡邉昌克, HUANG Hailing, 中谷公貴, 高橋雄介, 林美加子

日本歯科保存学会学術大会プログラムおよび講演抄録集(Web), 157th, 2022
Search for the functional site of a protein that promotes pulpal wound healing process

渡邉昌克, 岡本基岐, 小道俊吾, HAILING Huang, 松本紗也子, 森山輝一, 高橋雄介, 林美加子

日本歯科保存学会学術大会プログラムおよび講演抄録集(Web), 156th, 2022
応用したい!さまざまな材料からみた臨床テクニック洗浄編-3 根管洗浄によるスミヤー層除去および象牙質脱灰の形態学的検討

川西雄三, 前薗葉月, 高橋雄介, 林美加子

Quintessence, 2021
根管充填用シーラーが生体組織に与える影響のラット皮下埋入モデルを用いた評価

松本紗也子, 岡本基岐, 森山輝一, 渡邉昌克, 黄海玲, 三浦治郎, 杉山敬多, 高橋雄介, 林美加子

日本再生医療学会総会(Web), 20th, 2021
Effect of calcium hydroxide intracanal medicament on wound healing of periapical tissue

森山輝一, 岡本基岐, 松本紗也子, 渡邉昌克, HUANG Hailing, 高橋雄介, 林美加子

日本歯科保存学会学術大会プログラムおよび講演抄録集(Web), 154th, 2021
Evaluation of root canal preparation ability using a novel drive system

岡本基岐, 松本紗也子, 森山輝一, 渡邉昌克, HUANG Hailing, 三浦治郎, 杉山敬多, 米田直道, 的場一成, 高橋雄介 …

日本歯科保存学会学術大会プログラムおよび講演抄録集(Web), 154th, 2021
根尖周囲組織の創傷治癒過程においてBMP由来ペプチドが与える影響についての相互作用解析

渡邉昌克, 岡本基岐, 松本沙也子, 森山輝一, 高橋雄介, 林美加子

日本歯科医師会雑誌, 74(4), 2021
新規駆動形式NiTiロータリーファイルの根管形成能の評価

岡本基岐, 松本紗也子, 森山輝一, 渡邉昌克, 的場一成, 高橋雄介, 林美加子

日本歯科医師会雑誌, 74(4), 2021
Morphological investigation of dentin erosion after root canal irrigation

川西雄三, 植木柚衣, 西村佳保里, 内藤克昭, 外園真規, 前薗葉月, 高橋雄介, 林美加子

日本歯内療法学会学術大会プログラム・抄録集, 41st, 2020
Effect of Super MTA Paste on the wound healing process of pulp tissue

松本紗也子, 岡本基岐, 渡邉昌克, ALI Manahil, HUANG Hailing, 小道俊吾, 高橋雄介, 林美加子

日本歯科保存学会学術大会プログラムおよび講演抄録集(Web), 152nd, 2020
生物学的覆髄材料の臨床的評価を目指したラット覆髄モデルの開発

岡本基岐, 高橋雄介, HUANG Hailing, 小道俊吾, ALI Manahil, 渡邉昌克, 松本紗也子, 林美加子

日本歯科保存学会学術大会プログラムおよび講演抄録集(Web), 151st, 2019
生物学的根拠に基づくペプチド覆髄剤の開発

高橋雄介, 渡邉昌克, 岡本基岐, 小道俊吾, ALI Manahil, HUANG Hailing, 松本紗也子, 林美加子

日本歯科保存学会学術大会プログラムおよび講演抄録集(Web), 151st, 2019
S-PRGセメントによる第三象牙質形成機序の解明

岡本基岐, MANAHIL ALi, 小道俊吾, 渡邉昌克, 黄海玲, 伊藤勇紀, 三浦治郎, 広瀬雄二郎, 水平学, 高橋雄介 …

日本再生医療学会総会(Web), 18th, 2019
歯髄創傷治癒過程におけるProtein S100-A7の局在解析

小道俊吾, 高橋雄介, 岡本基岐, ALI Manahil. S, 渡邉昌克, 林美加子

日本歯科保存学会学術大会プログラムおよび講演抄録集(Web), 148th, 2018
Er:YAGレーザーの歯髄保存療法における有効性の検討

岡本基岐, 小道俊吾, 渡邉昌克, 八木香子, 成瀬陽菜, 伊藤勇紀, 高橋雄介, 林美加子

日本レーザー歯学会総会・学術大会プログラム・講演抄録集, 29th, 2017
S-PRGフィラー含有セメントのEndodonticセメントとしての応用

岡本基岐, 小道俊吾, 伊藤勇紀, 栗木菜々子, 渡邉昌克, 高橋雄介, 林美加子

日本歯内療法学会学術大会プログラム・抄録集, 38th, 2017
低酸素誘導因子(HIF-1)による第三象牙質形成に与える影響

岡本基岐, 小道俊吾, MANAHIL Ali, 渡邉昌克, 高橋雄介, 林美加子

日本歯科保存学会学術大会プログラムおよび講演抄録集(Web), 147th, 2017
Effects of the antibacterial monomer 12-methacryloyloxydodecylpyridinium bromide (MDPB) on bacterial viability and metabolism

Naomi Izutani, Satoshi Imazato, Kazuko Nakajo, Nobuhiro Takahashi, Yusuke Takahashi, Shigeyuki Ebisu, Roy R. B. Russell

EUROPEAN JOURNAL OF ORAL SCIENCES, 119(2) 175-181, Apr, 2011
Effects of the antibacterial monomer 12-methacryloyloxydodecylpyridinium bromide (MDPB) on bacterial viability and metabolism

N. Izutani, S. Imazato, K. Nakajo, N. Takahashi, Y. Takahashi, S. Ebisu, R.R. Russell

Eur. J. Oral. Sci., 119 (2): 175-181, Apr, 2011 Peer-reviewed

Books and Other Publications

MTAアップデート : 生体材料としての現状と展望

興地, 隆史, 高橋雄介 (Role: Contributor, MTAによる歯髄保存療法)

ヒョーロン・パブリッシャーズ, Jul, 2022 (ISBN: 9784864320726)
Pulp conservation using adhesive/functional materials

Yusuke Takahashi, Mikako Hayashi (Role: Contributor, Pulp conservation using MTA)

Oct, 2020
次世代の歯の治療－歯髄・根尖歯周組織の再生－① バイオロジカル歯髄創傷治癒誘導② －MMPファミリー分子－

高橋雄介

歯界展望, Jul, 2014
歯内療法学専門用語集

高橋雄介 (Role: Joint author)

日本歯科保存学会、日本歯内療法学会, Jun, 2013
Dental tissue inflammation and regeneration

Takahashi Y, Cooper PR, Smith AJ (Role: Joint author)

Nova Science Publishers, Oct, 2010
保存修復学専門用語集

恵比須繁之, 岩見行晃, 高橋雄介 (Role: Contributor)

医歯薬出版, Mar, 2009
生命歯科医学のカッティングエッジ

恵比須繁之, 今里聡, 竹重文雄, 林美加子, 野杁由一郎, 岩見行晃, 伊藤祥作, 高橋雄介, 薮根敏晃 (Role: Joint author)

大阪大学出版会, Mar, 2008
Fluoride ion released from glass-ionomer cement is responsible to inhibit the acid production of caries-related oral streptococci

Nakajo K, Takahashi Y, Kiba W, Imazato S, Takahashi N (Role: Contributor)

Springer Japan, Jun, 2007
う蝕による歯髄への感染

高橋雄介 (Role: Joint translator)

クインテッセンス出版, Mar, 2003

Teaching Experience

2020

Recent Advance in Oral Health
2020

Oro-facial Pain
2020

Operative Dentistry
2020

Lecture of Advanced Endodontology
2020

Advanced Endodontology Seminar
2020

Lecture of Advanced Conservative Dentistry
2020

Advanced Conservative Dentistry Seminar
2019

Lecture of Advanced Endodontology
2019

Advanced Endodontology Seminar
2019

Lecture of Advanced Conservative Dentistry
2019

Advanced Conservative Dentistry Seminar
2019

Modern Cariology
2019

Recent Advance in Oral Health
2019

Oro-facial Pain
2019

Operative Dentistry
2018

Modern Cariology
2018

Oro-facial Pain
2018

Advanced Conservative Dentistry Seminar
2018

Lecture of Advanced Conservative Dentistry
2018

Advanced Endodontology Seminar

Professional Memberships

Works

Research Projects

Development of a novel peptide drug against irreversible pulpitis using rat caries derived pulpitis model

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2022 - Mar, 2025
口腔細菌の薬剤耐性化および各種抗生剤に対する交叉耐性獲得の網羅的検索

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2021 - Mar, 2024

廣瀬奈々子, 高橋雄介, 北川晴朗
Development of pulp capping material based on the wound healing mechanism of the pulp tissue using bioinformatics

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2020

TAKAHASHI YUSUKE
Development of hydrogels with the ability to release antimicrobials for long term and their application to various resin-based materials

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2017

Imazato Satoshi
S-PRGフィラー含有水性ペーストの覆髄剤および根管貼薬剤としての応用

株式会社松風, 2017
S-PRG含有試作セメントならびに新規イオン追加試作セメントの覆髄剤としての応用

株式会社松風, 2016
Comprehensive in situ analysis of dental biofilm formation and control

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2012 - Mar, 2015

EBISU Shigeyuki, NOIRI Yuichiro, KINOMOTO Yoshifumi, YAMAGUCHI Mikiyo, ASAHI Youko, TAKAHASHI Yusuke
Identification of degraded dentin matrix proteins and application as a pulp capping material

2013
象牙質基質タンパク分解産物が象牙質―歯髄複合体の治癒に与える影響

2011
The pursuit of conservative dental treatment design in a new era by diverse utilization of an antibacterial monomer

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, 2007 - 2010

IMAZATO Satoshi, NOIRI Yuichiro, HAYASHI Mikako, NAKANO Takayoshi, TAKAHASHI Yusuke
修復象牙質形成過程におけるマトリックスメタロプロテアーゼの局在および機能解析

2009
修復象牙質形成における発現遺伝子のプロファイリング

2008
新規の化学的歯質接着メカニズムの創出-プレ配置された水素結合の応用-

科学研究費助成事業, 萌芽研究, 日本学術振興会, 2006 - 2007

今里聡, 高橋雄介, 上山憲一
修復象牙質形成における発現遺伝子のプロファイリング

2007
IL-6シグナルに潜むネガティブフィードバック機構の炎症性骨・歯根吸収への応用

2006
う蝕原性細菌表層におけるレジンモノマーの重合現象に関する多面的解析

2006
う蝕原性細菌表層におけるレジンモノマーの重合現象に関する多面的解析

2005
Pulp Biology
-
歯髄生物学

科学研究費補助金

Industrial Property Rights

特願2021-112587 Peptides and associated components

Yusuke Takahashi, Masakatsu Watanabe, Motoki Okamoto, Mikako Hayashi, Kei Kanie, Ryuji Katoh, Yuji Narita, Aika Ogata
PCT/JP2019/42742, 象牙質-歯髄を再生させる新規直接覆髄材料

岡本基岐, 高橋雄介, 林美加子, 蟹江慧, 加藤竜司, 緒方藍歌, 成田裕司, 荏原充宏, 宇都甲一郎
2018-205226 象牙質-歯髄を再生させる新規直接覆髄材料

岡本基岐, 高橋雄介, 林美加子, 蟹江慧, 加藤竜司, 緒方藍歌, 成田裕司, 荏原充宏, 宇都甲一郎

Academic Activities

大阪大学大学院歯学研究科第15回市民フォーラム「治せなかった病気が治る、最新歯科治療」

Other

大阪大学歯学研究科・大阪大学歯学部付属病院, Dec, 2017

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