2019年12月1日
Nationwide survey on cerebral amyloid angiopathy in Japan
European Journal of Neurology
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- 巻
- 26
- 号
- 12
- 開始ページ
- 1487
- 終了ページ
- 1493
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1111/ene.14031
© European Academy of Neurology 2019 Background and purpose: A nationwide survey was conducted to understand the epidemiology of cerebral amyloid angiopathy-related intracerebral hemorrhage (CAA-related ICH) and cerebral amyloid angiopathy-related inflammation/vasculitis (CAA-ri) in Japan. Methods: To estimate the total number and clinical features of patients with CAA-related ICH and CAA-ri between January 2012 and December 2014 and to analyze their clinical features, questionnaires were sent to randomly selected hospitals in Japan. Results: In the first survey, 2348 of 4657 departments responded to the questionnaire (response rate 50.4%). The total numbers of reported patients with CAA-related ICH and CAA-ri were 1338 and 61, respectively, and their total numbers in Japan were estimated to be 5900 [95% confidence interval (CI) 4800–7100] and 170 (95% CI 110–220), respectively. The crude prevalence rates were 4.64 and 0.13 per 100 000 population, respectively. The clinical information of 474 patients with CAA-related ICH obtained in the second survey was as follows: (i) the average age of onset was 78.4 years; (ii) the prevalence increased with age; (iii) the disease was common in women; and (iv) hematoma most frequently occurred in the frontal lobe. Sixteen patients with CAA-ri for whom data were collected in the second survey had the following characteristics: (i) median age of onset was 75 years; (ii) cognitive impairment and headache were the most frequent initial manifestations; and (iii) focal neurological signs, such as motor paresis and visual disturbance, were frequently observed during the clinical course. Conclusions: The numbers of patients with CAA-related ICH and CAA-ri in Japan were estimated.
- リンク情報
- ID情報
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- DOI : 10.1111/ene.14031
- ISSN : 1351-5101
- eISSN : 1468-1331
- PubMed ID : 31232495
- SCOPUS ID : 85069871058