Tetsuo Yamashita

Profile Information

Affiliation: Assistant Professor, Faculty of Medicine, Kagawa University

Degree: pharmaceutical sciences(Mar, 2004, The University of Tokyo)

ORCID ID: https://orcid.org/0000-0002-4076-991X
J-GLOBAL ID: 200901052778720998
researchmap Member ID: 5000103458

External link: http://www.med.kagawa-u.ac.jp/~cardiovasc-physiol/

Research Interests

Research Areas

Research History

2006 - Present

Assistant professor, Faculty of Medicine, Kagawa University
2004 - 2006

Research Associate, The Scripps Research Institute
2000 - 2001

Graduate School of Medicine, The University of Tokyo
2000 - 2001

Graduate School of Medicine, The University of Tokyo, Research subsidiary
2000

Faculty of Agriculture, Yamaguchi University

Education

Apr, 2001 - Mar, 2004

Graduate School of Pharmaceutical Sciences, The University of Tokyo
Apr, 1998 - Mar, 2000

Yamaguchi University
Apr, 1993 - Mar, 1997

Faculty of Agriculture, Yamaguchi University

Papers

Lactulose Modulates the Structure of Gut Microbiota and Alleviates Colitis-Associated Tumorigenesis.

Keizo Hiraishi, Feiyan Zhao, Lin-Hai Kurahara, Xiaodong Li, Tetsuo Yamashita, Takeshi Hashimoto, Yoko Matsuda, Zhihong Sun, Heping Zhang, Katsuya Hirano

Nutrients, 14(3), Feb 3, 2022 Peer-reviewed
The Auxiliary NADH Dehydrogenase Plays a Crucial Role in Redox Homeostasis of Nicotinamide Cofactors in the Absence of the Periplasmic Oxidation System in Gluconobacter oxydans NBRC3293.

Feronika Heppy Sriherfyna, Minenosuke Matsutani, Kensuke Hirano, Hisashi Koike, Naoya Kataoka, Tetsuo Yamashita, Eiko Nakamaru-Ogiso, Kazunobu Matsushita, Toshiharu Yakushi

Applied and environmental microbiology, 87(2), Jan 4, 2021 Peer-reviewed
Coagulation factor XI induces Ca²⁺ response and accelerates cell migration in vascular smooth muscle cells via proteinase-activated receptor 1.

Liu W, Hashimoto T, Yamashita T, Hirano K

American journal of physiology. Cell physiology, 316(3) C377-C392, Mar, 2019 Peer-reviewed
Ubiquinone binding site of yeast NADH dehydrogenase revealed by structures binding novel competitive- and mixed-type inhibitors

Tetsuo Yamashita, Daniel Ken Inaoka, Tomoo Shiba, Takumi Oohashi, So Iwata, Takao Yagi, Hiroaki Kosaka, Hideto Miyoshi, Shigeharu Harada, Kiyoshi Kita, Katsuya Hirano

Scientific Reports, 8(1) 2427-2427, Dec 1, 2018 Peer-reviewed
Increase in tumor suppressor Arf compensates gene dysregulation in in vitro aged adipocytes

Arif U. Hasan, Koji Ohmori, Takeshi Hashimoto, Kazuyo Kamitori, Fuminori Yamaguchi, Kumi Konishi, Takahisa Noma, Junsuke Igarashi, Tetsuo Yamashita, Katsuya Hirano, Masaaki Tokuda, Tetsuo Minamino, Akira Nishiyama, Masakazu Kohno

BIOGERONTOLOGY, 18(1) 55-68, Feb, 2017 Peer-reviewed
A key role of PGC-1α transcriptional coactivator in production of VEGF by a novel angiogenic agent COA-Cl in cultured human fibroblasts.

Junsuke Igarashi, Ryuji Okamoto, Tetsuo Yamashita, Takeshi Hashimoto, Sakiko Karita, Kozo Nakai, Yasuo Kubota, Maki Takata, Fuminori Yamaguchi, Masaaki Tokuda, Norikazu Sakakibara, Ikuko Tsukamoto, Ryoji Konishi, Katsuya Hirano

Physiological reports, 4(6), Mar, 2016 Peer-reviewed
Involvement of S1P1 receptor pathway in angiogenic effects of a novel adenosine-like nucleic acid analog COA-Cl in cultured human vascular endothelial cells

Junsuke Igarashi, Takeshi Hashimoto, Yasuo Kubota, Kazuyo Shoji, Tokumi Maruyama, Norikazu Sakakibara, Yoh Takuwa, Yoshihiro Ujihara, Yuki Katanosaka, Satoshi Mohri, Keiji Naruse, Tetsuo Yamashita, Ryuji Okamoto, Katsuya Hirano, Hiroaki Kosaka, Maki Takata, Ryoji Konishi, Ikuko Tsukamoto

Pharmacology Research and Perspectives, 2(5) e00068, Oct 1, 2014 Peer-reviewed
Mifepristone Promotes Adiponectin Production and Improves Insulin Sensitivity in a Mouse Model of Diet-Induced-Obesity

Takeshi Hashimoto, Junsuke Igarashi, Arif U. Hasan, Koji Ohmori, Masakazu Kohno, Yukiko Nagai, Tetsuo Yamashita, Hiroaki Kosaka

PLOS ONE, 8(11) :e79724, Nov, 2013 Peer-reviewed
The structure of the yeast NADH dehydrogenase (Ndi1) reveals overlapping binding sites for water- and lipid-soluble substrates

Momi Iwata, Yang Lee, Tetsuo Yamashita, Takao Yagi, So Iwata, Alexander D. Cameron, Megan J. Maher

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 109(38) 15247-15252, Sep, 2012 Peer-reviewed
Reaction Mechanism of Single Subunit NADH-Ubiquinone Oxidoreductase (Ndi1) from Saccharomyces cerevisiae EVIDENCE FOR A TERNARY COMPLEX MECHANISM

Yu Yang, Tetsuo Yamashita, Eiko Nakamaru-Ogiso, Takeshi Hashimoto, Masatoshi Murai, Junsuke Igarashi, Hideto Miyoshi, Nozomu Mori, Akemi Matsuno-Yagi, Takao Yagi, Hiroaki Kosaka

JOURNAL OF BIOLOGICAL CHEMISTRY, 286(11) 9287-9297, Mar, 2011 Peer-reviewed
Characterization of the Ubiquinone Binding Site in the Alternative NADH-Quinone Oxidoreductase of Saccharomyces cerevisiae by Photoaffinity Labeling

Masatoshi Murai, Tetsuo Yamashita, Mai Senoh, Yuko Mashimo, Michihiko Kataoka, Hiroaki Kosaka, Akemi Matsuno-Yagi, Takao Yagi, Hideto Miyoshi

BIOCHEMISTRY, 49(13) 2973-2980, Apr, 2010 Peer-reviewed
Recombinant expression and redox properties of triheme c membrane-bound quinol peroxidase

Eizo Takashima, Hiroyuki Yamada, Tetsuo Yamashita, Kazunobu Matsushita, Kiyoshi Konishi

FEMS MICROBIOLOGY LETTERS, 302(1) 52-57, Jan, 2010 Peer-reviewed
Transforming growth factor-beta 1 downregulates caveolin-1 expression and enhances sphingosine 1-phosphate signaling in cultured vascular endothelial cells

Junsuke Igarashi, Kazuyo Shoji, Takeshi Hashimoto, Tetsuya Moriue, Kozo Yoneda, Tomoko Takamura, Tetsuo Yamashita, Yasuo Kubota, Hiroaki Kosaka

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 297(5) C1263-C1274, Nov, 2009 Peer-reviewed
Roles of bound quinone in the single subunit NADH-quinone oxidoreductase (Ndi1) from Saccharomyces cerevisiae

Tetsuo Yamashita, Eiko Nakamaru-Ogiso, Hideto Miyoshi, Akemi Matsuno-Yagi, Takao Yagi

JOURNAL OF BIOLOGICAL CHEMISTRY, 282(9) 6012-6020, Mar, 2007 Peer-reviewed
Possibility of transkingdom gene therapy for Complex I diseases

Takao Yagi, Byoung Boo Seo, Elko Nakamaru-Ogiso, Mathieu Marella, Jennifer Barber-Singh, Tetsuo Yamashita, Akemi Matsuno-Yagi

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 1757(5-6) 708-714, May, 2006 Peer-reviewed
Can a single subunit yeast NADH dehydrogenase (Ndi1) remedy diseases caused by respiratory complex I defects?

Takao Yagi, Byoung Boo Seo, Eiko Nakamaru-Ogiso, Mathieu Marella, Barber-Singh J, Tetsuo Yamashita, Kao M.C, Akemi Matsuno-Yagi

Rejuvenation Res., 9(2) 191-197, 2006 Peer-reviewed
A gamma-lactone form nafuredin, nafuredin-gamma, also inhibits helminth complex I

K Shiomi, H Ui, H Suzuki, H Hatano, T Nagamitsu, D Takano, H Miyadera, T Yamashita, K Kita, H Miyoshi, A Harder, H Tomoda, S Omura

JOURNAL OF ANTIBIOTICS, 58(1) 50-55, Jan, 2005 Peer-reviewed
Rhodoquinone reaction site of mitochondrial complex I, in parasitic helminth, Ascaris suum

T Yamashita, T Ino, H Miyoshi, K Sakamoto, A Osanai, E Nakamaru-Ogiso, K Kita

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 1608(2-3) 97-103, Feb, 2004 Peer-reviewed
Structure at 1.9 angstrom resolution of a quinohemoprotein alcohol dehydrogenase from Pseudomonas putida HK5

ZW Chen, K Matsushita, T Yamashita, TA Fujii, H Toyama, O Adachi, HD Bellamy, FS Mathews

STRUCTURE, 10(6) 837-849, Jun, 2002 Peer-reviewed
Structural studies of a soluble monomeric quinohemoprotein alcohol dehydrogenase from Pseudomonas putida HK5

FS Mathews, ZW Chen, K Matsushita, T Yamashita, N Aoki, H Toyama, O Adachi, HD Bellamy

BIOCHEMISTRY AND MOLECULAR BIOLOGY OF VITAMIN B6 AND PQQ-DEPENDENT PROTEINS, 213-218, 2000 Peer-reviewed

Misc.

Gluconobacter属酢酸菌においてII型NADH脱水素酵素によるNADPH酸化が生育に及ぼす影響

平野健輔, Sriherfyna Feronika Heppy, 松谷峰之介, 片岡尚也, 山下哲生, 小木曾映子[中丸], 松下一信, 薬師寿治

日本生化学会大会プログラム・講演要旨集, 92回 [1T06a-01], Sep, 2019
Gluconobacter属酢酸菌においてII型NADH脱水素酵素によるNADPH酸化が生育に及ぼす影響

平野健輔, Sriherfyna Feronika Heppy, 松谷峰之介, 片岡尚也, 山下哲生, 小木曾映子[中丸], 松下一信, 薬師寿治

日本生化学会大会プログラム・講演要旨集, 92回 [1T06a-01], Sep, 2019
血液凝固第XI因子の血管機能調節因子としての新たな機能の発見

劉文華, 橋本剛, 山下哲生, 平野勝也

日本生理学雑誌, 81(2) 35-35, May, 2019
血管平滑筋細胞において凝固第XI因子はトロンビン受容体PAR1を活性化し、細胞内Ca2+シグナルを発生させ、細胞遊走を促進する

平野勝也, 劉文華, 橋本剛, 山下哲生

血管, 42(1) 54-54, Jan, 2019
Proteinase-activated receptor 1 (PAR₁)-mediated cellular effects of coagulation factor XI in vascular smooth muscle cells

Hirano Katsuya, Liu Wenhua, Hiashimoto Takeshi, Yamashita Tetsuo

Proceedings for Annual Meeting of The Japanese Pharmacological Society, 92 2-O-30, 2019
新規競合阻害剤および混合型阻害剤との共結晶構造解析による酵母Type II NADH脱水素酵素Ndi1におけるユビキノン結合部位の同定

山下哲生, 稲岡健ダニエル, 志波智生, 大橋拓未, 岩田想, 矢木隆雄, 小坂博昭, 三芳秀人, 原田繁春, 北潔, 平野勝也

日本生化学会大会プログラム・講演要旨集, 91回 [1P-115], Sep, 2018
Gluconobacter属酢酸菌が持つ2つのII型NADH脱水素酵素の解析

フェロニカ・ヘピィ・スリヘルフィナ, 江本祥子, 松谷峰之介, 小池尚史, 片岡尚也, 山下哲生, 小木曾映子[中丸], 松下一信, 薬師寿治

日本生化学会大会プログラム・講演要旨集, 91回 [3P-128], Sep, 2018
嫌気条件とNAD(P)HはApoptosis-inducing factorの大腸菌膜からの解離を抑制する

山下哲生, 松本感, 橋本剛, 五十嵐淳介, 小坂博昭, 平野勝也

日本生理学雑誌, 80(3) 36-36, Aug, 2018
血液凝固第XI因子が引き起こす血管平滑筋細胞のCa2+シグナルの発生メカニズムの解明

劉文華, 橋本剛, 山下哲生, 平野勝也

日本生理学雑誌, 80(3) 37-37, Aug, 2018
競合および混合阻害剤との共結晶構造解析により明らかとなった酵母由来Type II NADH脱水素酵素のユビキノン結合部位

山下哲生, 稲岡健ダニエル, 志波智生, 三芳秀人, 原田繁春, 北潔, 平野勝也

日本農芸化学会中四国支部講演会講演要旨集(Web), 51st, 2018
血液凝固第XI因子は電位作動性Ca2+チャネルを介して血管平滑筋細胞にCa2+シグナルを発生させる

平野勝也, 劉文華, 橋本剛, 山下哲生

血管, 41(1) 37-37, Jan, 2018
Apoptosis-inducing factorと大腸菌膜との相互作用の解析

松本感, 山下哲生, 橋本剛, 五十嵐淳介, 小坂博昭, 平野勝也

日本生理学雑誌, 79(1) 43-44, Feb, 2017
凝固第XI因子の血管平滑筋作用

平野勝也, 劉文華, 橋本剛, 山下哲生

日本循環薬理学会口演要旨集, 27th, 2017
凝固第XI因子が引き起こす血管平滑筋細胞のカルシウムシグナル伝達

平野勝也, 劉文華, 橋本剛, 山下哲生, 五十嵐淳介

血管, 40(1) 40-40, Jan, 2017
熱帯熱マラリア原虫のミトコンドリア型Type II NADH dehydrogenaseの生化学的解析及び新規阻害剤の探索

大橋拓未, 稲岡ダニエル健, 小松谷啓介, BALOGUN Emmanuel O., ERI Amalia, 山下哲生, 志波智生, 佐藤暖, 野崎智義, 原田繁春, 北潔

日本寄生虫学会大会プログラム・抄録集, 85th, 2016
新規アデノシン類似化合物COA-CI(コアクロル)はcAMP/CREB/PGC-1αの経路を介して血管内皮成長因子(VEGF)の産生を促進する

岡本隆司, 五十嵐淳介, 橋本剛, 山下哲生, 苅田咲子, 窪田泰夫, 高田麻紀, 小西良士, 塚本郁子, 平野勝也

日本生理学雑誌, 78(1) 4-4, Jan, 2016
新規アデノシン類似化合物COA-C1(コアクロル)はヒト皮膚由来線維芽細胞において結合組織成長因子(CTGF)の発現を抑制する

苅田咲子, 五十嵐淳介, 岡本隆司, 山下哲生, 橋本剛, 窪田泰夫, 塚本郁子, 小西良士, 平野勝也

日本生理学雑誌, 78(1) 9-9, Jan, 2016
Activation of cAMP/CREB/PGC-1 alpha Pathway Plays a Key Role for a Novel Adenosine-like Angiogenic Agent COA-CI to Induce Production of Vascular Endothelial Growth Factor (VEGF) in Cultured Human Fibroblasts

Ryuji Okamoto, Junsuke Igarashi, Takeshi Hashimoto, Tetsuo Yamashita, Kazuyo Shoji, Yasuo Kubota, Norikazu Sakakibara, Ikuko Tsukamoto, Ryoji Konishi, Katsuya Hirano

CIRCULATION, 132, Nov, 2015
A Key Role of PGC-1 alpha Co-transcription Factor, but not HIF1 alpha Transcription Factor, in Production of Vascular Endothelial Growth Factor (VEGF) by a Novel Angiogenic Agent COA-CI in Cultured Human Fibroblasts

Ryuji Okamoto, Junsuke Igarashi, Tetsuo Yamashita, Takeshi Hashimoto, Sakiko Karita, Kazuyo Shoji, Yasuo Kubota, Maki Takata, Fuminori Yamaguchi, Masaaki Tokuda, Norikazu Sakakibara, Ikuko Tsukamoto, Ryoji Konishi, Katsuya Hirano

CIRCULATION, 132, Nov, 2015
新規アデノシンアナログCOA-Clの血管新生作用

塚本郁子, 五十嵐淳介, 橋本剛, 山下哲生, 榊原紀和, 丸山徳見, 高田麻紀, 窪田泰夫, 平野勝也, 小西良士

西日本皮膚科, 77(3) 312-312, Jun, 2015

Books and Other Publications

Biochemistry and Molecular Biology of Vitamine B6 and PQQ-dependent Protein

Birkhauser/Switzerland, 2000

Presentations

Biochemical characterization of the putative sulfide:quinone oxidoreductase from an intestinal parasite Schistosoma mansoni

Talaam Keith Kiplangat, Yuichi Matsuo, Acharjee Rajib, Tetsuo Yamashita, Tetsuro Kawano, Endah Dwi Hartuti, Tetsuro Matsunaga, Tomoyoshi Nozaki, Takaaki Akaike, Shinjiro Hamano, Kiyoshi Kita, Daniel Ken Inaoka

6th World Congress on Hydrogen Sulfide in Biology & Medicine, May 19, 2022
Preparation of enzymatically active complex of myosin light chain phosphatase by using yeast expression system

Mar 16, 2022
Characterization of putative sulfide:quinone oxidoreductase from an intestinal parasite Schistosoma mansoni

Talaam Keith Kiplangat, Yuichi Matsuo, Acharjee Rajib, Tetsuo Yamashita, Kawano Tetsuro, Endah Dwi Hartuti, Tomoyoshi Nozaki, Shinjiro Hamano, Kiyoshi Kita, Daniel Ken Inaoka

Dec 16, 2021
N-terminal region of apoptosis-inducing factor facilitates dimer formation by stabilizing the charge transfer complex

Tetsuo Yamashita, Takeshi Hashimoto, Junsuke Igarashi, Hiroaki Kosaka, Katsuya Hirano

The 97th Annual Meeting of the Physiological Society of Japan, Mar 18, 2020
Apoptosis-inducing factorのN末端領域は電位移動錯体の安定化を介して二量体形成を制御する

山下哲生, 橋本剛, 五十嵐淳介, 小坂博昭, 平野勝也

第71回日本生理学会中国四国地方会, Nov 23, 2019
Dissociation of Apoptosis-inducing factor from the E. coli membrane is suppressed by NAD(P)H

Tetsuo Yamashita, Takeshi Hashimoto, Junsuke Igarashi, Hiroaki Kosaka, Katsuya Hirano

The 9th Federation of Asian and Oceanian Physiological Societies Congress, Mar 28, 2019
Proteinase-activated receptor 1 (PAR1)-mediated cellular effects of coagulation factor XI in vascular smooth muscle cells

Katsuya Hirano, Wenhua Liu, Takeshi Hashimoto, Tetsuo Yamashita

The 92nd Annual Meeting of the Japanese Pharmacological Society, Mar 14, 2019
血管平滑筋細胞において凝固第XI因子はトロンビン受容体PAR1を活性化し、細胞内Ca2+シグナルを発生させ、細胞遊走を促進する

平野勝也, 劉文華, 橋本剛, 山下哲生

第48回心脈管作動物質学会, Feb 7, 2019
A Novel Function of Activated Coagulation Factor XI as a Regulator of Intracellular Ca2+ Signal and Cell Migration in Vascular Smooth Muscle Cells

Wenhua Liu, Takeshi Hashimoto, Tetsuo Yamashita, Katsuya Hirano

American Heart Association Scientific Sessions Meeting, Nov 10, 2018
Identification of ubiquinone binding site of Ndi1, a yeast Type II NADH dehydrogenase, by revealing co-crystal structure with novel competitive and mixed-type inhibitors

YAMASHITA Tetsuo

Sep 25, 2018
血管平滑筋細胞において凝固第XI因子が引き起こす細胞遊走・増殖促進作用

劉文華, 橋本剛, 山下哲生, 平野勝也

第60回日本平滑筋学会総会, Aug 16, 2018
A role of coagulation factor XI as a regulator of vascular smooth muscle migration

Wenhua Liu, Takeshi Hashimoto, Tetsuo Yamashita, Katsuya Hirano

18th World Congress of Basic and Clinical Pharmacology, Jul 1, 2018
競合および混合阻害剤との共結晶構造解析により明らかとなった酵母由来 Type II NADH脱水素酵素のユビキノン結合部位

山下哲生, 稲岡健ダニエル, 志波智生, 三芳秀人, 原田繁春, 北潔, 平野勝也

日本農芸化学会中四国支部第51回講演会（例会）, Jun 16, 2018
凝固第Ⅺ因子の血管平滑筋作用

平野勝也, 劉文華, 橋本剛, 山下哲生

第27回日本循環薬理学会, Dec 1, 2017
嫌気条件とNAD(P)HはApoptosis-inducing factorの大腸菌膜からの解離を抑制する

山下哲生, 松本感, 橋本剛, 五十嵐淳介, 小坂博昭, 平野勝也

第 69 回日本生理学会中国・四国地方会, Oct 28, 2017
血液凝固第XI因子が引き起こす血管平滑筋細胞のCa2+シグナルの発生メカニズムの解明

劉文華, 橋本剛, 山下哲生, 平野勝也

第 69 回日本生理学会中国・四国地方会, Oct 28, 2017
血管平滑筋細胞において凝固第XI因子が引き起こすプロテイナーゼ活性化型受容体１を介した電位作動性カルシウムチャネル依存性Ca2+流入作用

劉文華, 橋本剛, 山下哲生, 平野勝也

第59回日本平滑筋学会総会, Aug 23, 2017
Mifepristone, a steroid receptor antagonist, induces hepatic steatosis in association with upregulation of resistin expression in liver.

Takeshi Hashimoto, Junsuke Igarashi, Tetsuo Yamashita, Katsuya Hirano

The 94th Annual Meeting of the Physiological Society of Japan, Mar 28, 2017
A novel angiogenic agent COA-Cl promotes VEGF secretion from mouse C2C12 skeletal myocytes via the activation of cAMP/PKA/CREB/PGC-1α signaling axis

Junsuke Igarashi, Ryuji Okamoto, Takeshi Hashimoto, Tetsuo Yamashita, Yasuo Kubota, Ikuko Tsukamoto, Norikazu Sakakibara, Ryoji Konishi, Katsuya Hirano

The 94th Annual Meeting of the Physiological Society of Japan, Mar 28, 2017
NAD(P)H and low ionic strength suppresses dissociation of apoptosis-inducing factor from the E. coli membrane.

Tetsuo Yamashita, Kan Matsumoto, Takeshi Hashimoto, Junsuke Igarashi, Hiroaki Kosaka, Katsuya Hirano

The 94th Annual Meeting of the Physiological Society of Japan, Mar 28, 2017

Teaching Experience

Professional Memberships

Works

Research Projects

新規血管病治療薬開発に向けた平滑筋ミオシン軽鎖ホスファターゼの構造解析

令和４年度研究推進事業, 香川大学, Apr, 2022 - Mar, 2023
平滑筋ミオシンホスファターゼ活性制御の構造基盤とその機能的意義

⾹川⼤学研究推進事業, Apr, 2021 - Mar, 2022

山下哲生
呼吸鎖酵素NDH-2のユビキノン還元反応の分子機構と構造的基盤

若手研究, 香川大学, Apr, 2019 - Mar, 2020

山下哲生
呼吸鎖酵素NDH-2 のユビキノン還元反応の分子機構と構造的基盤

若手研究, 香川大学, Apr, 2018 - Mar, 2019

山下哲生
阻害剤作用機構研究を基盤とした呼吸鎖酵素ＮＤＨ-2の反応機構の解析

基盤研究（Ｃ）, 独立行政法人日本学術振興会, Apr, 2015 - Mar, 2018

山下哲生
Type II NADH脱水素酵素を標的とした新機抗寄生虫薬開発のための基礎研究

若手研究, 香川大学, Apr, 2014 - Mar, 2015

山下哲生
ミトコンドリア呼吸鎖酵素ＮＤＨ-2における活性酸素の生成抑制機構と構造的基盤

若手研究（Ｂ）, 独立行政法人日本学術振興会, Apr, 2013 - Mar, 2015

山下哲生
ミトコンドリアにおけるAIFの生理機能および細胞死誘導の分子機構の解析

基盤研究（Ｃ）, 独立行政法人日本学術振興会, Apr, 2011 - Mar, 2014

小坂博昭
シングルサブユニット・NADH脱水素酵素における活性酸素の生成抑制機構の解析

若手研究, 香川大学, Apr, 2012 - Mar, 2013

山下哲生
酵母NADH-キノン酸化還元酵素における活性酸素の生成抑制機構

若手研究, 香川大学, Apr, 2011 - Mar, 2012

山下哲生
哺乳類ミトコンドリアにおけるシングルサブユニット・NADH脱水素酵素ホモログ（AIF）の構造と機能に関する研究

萌芽研究, 香川大学, Apr, 2009 - Mar, 2010

山下哲生
ミトコンドリア・エネルギー生成系における酵素結合型キノンの生理学的機能の解明

若手研究（萌芽研究）, 香川大学, Apr, 2007 - Mar, 2008

山下哲生
酵母ミトコンドリア呼吸鎖酵素におけるユビキノン還元反応の分子機構と構造的基盤

若手研究（スタートアップ）, 独立行政法人日本学術振興会, Apr, 2007 - Mar, 2008

山下哲生
酵母NADH脱水素酵素（NDH-2）の構造及び機能解析

2006
Mechanism of ROS suppression in Yeast NADH Dehydrogenase

2006

Social Activities

The 63th Annual Meeting of the Japan Society of Smooth Muscle Research

Logistic support

the Japan Society of Smooth Muscle Research, Aug 6, 2021 - Aug 7, 2021
The 95th Annual Meeting of the Physiological Society of Japan

Logistic support

The Physiological Society of Japan, Mar 27, 2018 - Mar 31, 2018

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