Yohei Egami

Profile Information

Affiliation: Assistant Professor, Faculty of Medicine, Kagawa University

Degree: 博士（医学）
修士（理学）
立命館大学

J-GLOBAL ID: 200901069787366501
researchmap Member ID: 5000103629

Research Interests

Research Areas

Life sciences / Anatomy /

Research History

2018 - Present

Faculty of Medicine, Kagawa University
2007 - 2017

Faculty of Medicine, Kagawa University
2006 - 2007

Faculty of Medicine, Kagawa University

Education

- 2006

Osaka City University
- 2002

Osaka University

Awards

Mar, 2014

日本解剖学会奨励賞
Sep, 2013

日本組織細胞化学会論文賞

Papers

A novel DENND1B-localized structure found at the basal side of adherent cells.

Eugene Won Park, Katsuhisa Kawai, Youhei Egami, Nobukazu Araki

Histochemistry and cell biology, 155(1) 9-18, Jan, 2021
Rab10-Positive Tubular Structures Represent a Novel Endocytic Pathway That Diverges From Canonical Macropinocytosis in RAW264 Macrophages.

Katsuhisa Kawai, Arata Nishigaki, Seiji Moriya, Youhei Egami, Nobukazu Araki

Frontiers in immunology, 12 649600-649600, 2021
Rab35 Targeting to the Plasma Membrane Is Dependent on the C-terminal Polybasic Cluster.

Katsuhisa Kawai, Youhei Egami, Arata Nishigaki, Nobukazu Araki

Acta histochemica et cytochemica, 53(4) 93-97, Aug 26, 2020 Peer-reviewed
Transient recruitment of M-Ras GTPase to phagocytic cups in RAW264 macrophages during FcγR-mediated phagocytosis

Youhei Egami, Nobukazu Araki

Microscopy, 67(2) 68-74, Apr 1, 2018 Peer-reviewed
RhoC regulates the actin remodeling required for phagosome formation during Fc gamma R-mediated phagocytosis

Youhei Egami, Katsuhisa Kawai, Nobukazu Araki

JOURNAL OF CELL SCIENCE, 130(24) 4168-4179, Dec, 2017 Peer-reviewed
Rac1 switching at the right time and location is essential for Fc gamma receptor-mediated phagosome formation

Yuka Ikeda, Katsuhisa Kawai, Akira Ikawa, Kyoko Kawamoto, Youhei Egami, Nobukazu Araki

JOURNAL OF CELL SCIENCE, 130(15) 2530-2540, Aug, 2017 Peer-reviewed
Cofilin contributes to phagocytosis of IgG-opsonized particles but not non-opsonized particles in RAW264 macrophages

Yanmeng Lu, Lei Cao, Youhei Egami, Katsuhisa Kawai, Nobukazu Araki

MICROSCOPY, 65(3) 233-242, Jun, 2016 Peer-reviewed
Molecular imaging analysis of Rab GTPases in the regulation of phagocytosis and macropinocytosis

Youhei Egami

ANATOMICAL SCIENCE INTERNATIONAL, 91(1) 35-42, Jan, 2016 Peer-reviewed
Activation-Inactivation Cycling of Rab35 and ARF6 Is Required for Phagocytosis of Zymosan in RAW264 Macrophages

Youhei Egami, Makoto Fujii, Katsuhisa Kawai, Yurie Ishikawa, Mitsunori Fukuda, Nobukazu Araki

JOURNAL OF IMMUNOLOGY RESEARCH, 2015 429439-429439, 2015 Peer-reviewed
Small GTPases and phosphoinositides in the regulatory mechanisms of macropinosome formation and maturation

Youhei Egami, Tomohiko Taguchi, Masashi Maekawa, Hiroyuki Arai, Nobukazu Araki

FRONTIERS IN PHYSIOLOGY, 5 374-374, Sep, 2014 Peer-reviewed
Development of an automated fluorescence microscopy system for photomanipulation of genetically encoded photoactivatable proteins (optogenetics) in live cells

Nobukazu Araki, Yuka Ikeda, Takuma Kato, Katsuhisa Kawai, Youhei Egami, Katsuya Miyake, Nobuhide Tsurumaki, Mitsunari Yamaguchi

MICROSCOPY, 63(3) 255-260, Jun, 2014 Peer-reviewed
Rac1-Dependent Lamellipodial Motility in Prostate Cancer PC-3 Cells Revealed by Optogenetic Control of Rac1 Activity

Takuma Kato, Katsuhisa Kawai, Youhei Egami, Yoshiyuki Kakehi, Nobukazu Araki

PLOS ONE, 9(5) e97749, May, 2014 Peer-reviewed
Dissecting the roles of Rac1 activation and deactivation in macropinocytosis using microscopic photo-manipulation

Makoto Fujii, Katsuhisa Kawai, Youhei Egami, Nobukazu Araki

SCIENTIFIC REPORTS, 3 2385-2385, Aug, 2013 Peer-reviewed
Rab20 Regulates Phagosome Maturation in RAW264 Macrophages during Fc Gamma Receptor-Mediated Phagocytosis

Youhei Egami, Nobukazu Araki

PLOS ONE, 7(4) e35663, Apr, 2012 Peer-reviewed
MICAL1 an F-actin-disassembly factor links membrane repair.

Miyake K, Egami Y, Matsuda C, Hamada M, Hayashi Y. K, McNeil P. L, Araki N

MOLECULAR BIOLOGY OF THE CELL, 23, 2012 Peer-reviewed
Spatiotemporal Localization of Rab20 in Live RAW264 Macrophages during Macropinocytosis

Youhei Egami, Nobukazu Araki

ACTA HISTOCHEMICA ET CYTOCHEMICA, 45(6) 317-323, 2012 Peer-reviewed
Rab35 regulates phagosome formation through recruitment of ACAP2 in macrophages during Fc gamma R-mediated phagocytosis

Youhei Egami, Mitsunori Fukuda, Nobukazu Araki

JOURNAL OF CELL SCIENCE, 124(21) 3557-3567, Nov, 2011 Peer-reviewed
Dynamic Changes in the Spatiotemporal Localization of Rab21 in Live RAW264 Cells during Macropinocytosis

Youhei Egami, Nobukazu Araki

PLOS ONE, 4(8) e6689, Aug, 2009 Peer-reviewed
Characterization of Rab21-positive tubular endosomes induced by PI3K inhibitors

Youhei Egami, Nobukazu Araki

EXPERIMENTAL CELL RESEARCH, 314(4) 729-737, Feb, 2008 Peer-reviewed
Phosphoinositide metabolism during membrane ruffling and macropinosome formation in EGF-stimulated A431 cells.

Nobukazu Araki, Youhei Egami, Yasuo Watanabe, Tanenori Hatae

Experimental cell research, 313(7) 1496-507, Apr 15, 2007 Peer-reviewed

Misc.

Rac1とphosphoinositidesに制御される新規エンドサイトーシス経路の解析

川合克久, 江上洋平, 荒木伸一

日本解剖学会総会・全国学術集会講演プログラム・抄録集, 125th, 2020
Annexins and the Partner Proteins S100 in Plasma Membrane Repair and Ectosome Generation

K. Miyake, C. Matsuda, M. Hamada, K. Kawai, Y. Egami, Y. Hayashi, P. L. McNeil, N. Araki

MOLECULAR BIOLOGY OF THE CELL, 24, 2013
P-50 Zymosan貪食過程におけるRit1 GTPaseの機能解析(免疫組織化学・機能解析関連領域,ポスター,第54回日本組織細胞化学会総会・学術集会)

江上洋平, 川合克久, 荒木伸一

日本組織細胞化学会総会プログラムおよび抄録集, (54) 99-99, 2013
高感度多光子顕微鏡による細胞膜修復のLIVEイメージング

三宅克也, 松田知栄, 江上洋平, 濱田萌, 林由起子, 荒木伸一

解剖学雑誌, 87(2) 44, Jun 1, 2012

Presentations

ACTN4-dependent layered-edge lamellipodia acting as a novel mode of invasive cancer cell migration

森下陽香, 川合克久, 江上洋平, 本田一文, 荒木伸一

第129回日本解剖学会総会・全国学術集会
Rit1-TBC1D10Bシグナリングによる貪食制御機構

江上洋平, 川合克久, 荒木伸一

第129回日本解剖学会総会・全国学術集会
ライブセルとCLEMで観察するラメリポディアの新形態

荒木伸一, 森下陽香, 川合克久, 江上洋平, 本田一文

日本顕微鏡学会第79回学術講演会 Invited
Live-cell imagingと光電子相関顕微鏡観察で明らかになった新しいタイプのラメリポディアの存在と特性

森下陽香, 川合克久, 江上洋平, 本田一文, 荒木伸一

第128回日本解剖学会総会・全国学術集会
Rab23 and Rab34 are regulators of sarcolemma repair

kana Murai, Youhei Egami, Katsuhisa Kawai, Nobukaza Araki, Takeshi Endo, Katsuya Miyake

Mar 27, 2022
Fc γレセプター介在性ファゴサイトーシス経路におけるTBC1D10Bの機能解析

江上洋平, 川合克久, 荒木伸一

第127回日本解剖学会総会・全国学術集会, Mar 27, 2022
Rabファミリー低分子量Gタンパク質による膜修復機構

村井花奈, 江上洋平, 川合克久, 荒木伸一, 三宅克也

Sep 11, 2021
Rac1とphosphoinositidesに制御される新規エンドサイトーシス経路の解析

川合克久, 江上洋平, 荒木伸一

第125回日本解剖学会総会・全国学術集会, Mar, 2020
TBC1D10Bはマクロファージにおける貪食抑制因子である

江上洋平, 川合克久, 荒木伸一

第124回日本解剖学会総会・全国学術集会, Mar, 2019
Rit1 GTPaseはFcγレセプター介在性のファゴゾーム形成を制御する

江上洋平

第123回日本解剖学会総会・全国学術集会, Mar, 2018
Fcγレセプター介在性ファゴサイトーシス過程におけるRit1 GTPaseの機能解析

江上洋平

2017年度生命科学系学会合同年次大会, Dec, 2017
新規マクロピノサイトーシス関連経路の形態と分子基盤

川合克久, 江上洋平, 荒木伸一

第122回日本解剖学会総会・全国学術集会, Mar, 2017
Rab23およびRab34の骨格筋線維膜修復時の動態

三宅克也, 荒木伸一, 川合克久, 江上洋平

第122回日本解剖学会総会・全国学術集会, Mar, 2017
Rab10-positive macropinosome-like structures provide a novel endocytic pathway

第120回日本解剖学会総会･全国学術集会, 第92回日本生理学会大会合同大会, 2015
低分子量GTPaseによるマクロピノサイトーシス及びファゴサイトーシスの制御に関する分子形態学的解析

江上洋平

第120回日本解剖学会総会･全国学術集会, 第92回日本生理学会大会合同大会, 2015
IgG依存性貪食と非依存性貪食過程へのcofilinの関与と形態様式の差異

路艶蒙, 曹蕾, 江上洋平, 川合克久, 荒木伸一

日本解剖学会第70回中国・四国支部学術集会, 2015
ファゴゾーム成熟過程におけるRab35の役割

川合克久, 江上洋平, 荒木伸一

第119回日本解剖学会総会・全国学術集会, Mar, 2014
Zymosan貪食過程におけるRit1 GTPaseのライブセルイメージングと機能解析

江上洋平, 川合克久, 荒木伸一

第119回日本解剖学会総会・全国学術集会, Mar, 2014
前立腺癌細胞移動（migration）における低分子量GTPase Rac1を介した制御機構のoptgenetics解析

加藤琢磨, 川合克久, 江上洋平, 荒木伸一, 筧善行

第23回泌尿器科分子・細胞研究会, 2014
ライブセルイメージングによる細胞膜修復を行う小胞膜の起源についての検討.

日本解剖学会第69回中国・四国支部学術集会, 2014

Professional Memberships

Research Projects

Live-cell imaging and CLEM reveal the presence and significance of a new type of lamellipodia

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2023 - Mar, 2026
低分子量Rap2B GTPaseによる新規エンドサイトーシス制御機構

科学研究費助成事業基盤研究(C), 基盤研究(C), 日本学術振興会, Apr, 2020 - Mar, 2024

江上洋平, 荒木伸一, 川合克久
新規非分解系エンドサイトーシス経路の生理的機能と病態との関連

科学研究費助成事業基盤研究(C), 基盤研究(C), 日本学術振興会, Apr, 2019 - Mar, 2023

川合克久, 荒木伸一, 江上洋平
Molecular and functional analysis of a novel endocytic pathway associated with macropinocytosis

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2022

Araki Nobukazu
Regulation of cellular immune system: a role of a TBC protein in phagosome formation

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2021

Youhei Egami
Development of a novel photodynamic therapy for tumors using a photosensitizing PI3K inhibitor.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2017

Araki Nobukazu
Regulation of cellular immune system: an involvement of Rit1 GTPase in phagosome formation

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2016

Egami Youhei
Control of macropinocytosis by photomanipulation of Rac1 activity

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2011 - Mar, 2015

ARAKI Nobukazu, KAWAI Katsuhisa, EGAMI Youhei, MIYAKE Katsuya, FUJII Makoto
Live Imaging of membrane repair by high sensitive multi-photon laser microscope in vivo system.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2010 - Mar, 2015

MIYAKE Katsuya, EGAMI Youhei, MATSUDA Chie, KANAGAWA Motoi, TANAKA Toru, FUKAI Naomi, YOSHIYAMA Masahiro, ARAKI Shinichi
mutual analysis of intracellular signaling and morphological change in phagosome formation and maturation

Grants-in-Aid for Scientific Research, Grant-in-Aid for Research Activity Start-up, Japan Society for the Promotion of Science, Aug, 2012 - Mar, 2014

KAWAI katsuhisa, ARAKI Nobukazu, MIYAKE Katusya, EGAMI Youhei
Development of an automated microscopic system for optogenetics using a mercury lamp fluorescence microscope

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2012 - Mar, 2014

ARAKI NOBUKAZU, EGAMI Youhei, KAWAI Katsuhisa, MIYAKE Katsuya, KATO Takuma
Live Imaging for Two-photon microscopy: Membrane repair in Squid Gian Axon.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, 2010 - 2012

MIYAKE Katsuya, TANAKA Toru, ARAKI Shinichi, EGAMI Youhei, MATSUDA Chie, FUKAI Naomi, KANAGAWA Motoi
Analysis of Rab35 GTPase: insight into cytoskeletal remodeling and membrane trafficking during phagocytosis

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, 2010 - 2012

EGAMI Youhei
Phagosome/macropinosome formation and membrane traffic

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2007 - 2008

ARAKI Nobukazu, EGAMI Youhei
Molecular machinery and signal transduction of phagocytosis and macropinocytosis

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2003 - 2006

ARAKI Nobukazu, HATAE Tanenori, EGAMI Youhei
ファゴサイトーシス・エンドサイトーシスの分子機構

基礎科学研究
Molecular machinery of macropinocytosis and phagocytosis Bioimaging

Basic Science Research Program

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