ISHIHARA Hisamitsu

J-GLOBAL         Last updated: Sep 3, 2019 at 02:58
ISHIHARA Hisamitsu
Nihon University
School of Medicine, Department of Medicine, -
Job title
Medical doctor
Research funding number

Research Areas

  • Clinical internal medicine / Metabolomics / Metabolism Studies


Faculty of Medicine, The University of Tokyo

Awards & Honors

May 2009
The Molecular Mechanisms of Pancreatic Beta-cell Failure in Type 2 Diabetes Mellitus, The Lilly Award

Published Papers

Trk-fused gene (TFG) regulates pancreatic β cell mass and insulin secretory activity.
Yamamotoya T, Nakatsu Y, Kushiyama A, Matsunaga Y, Ueda K, Inoue Y, Inoue MK, Sakoda H, Fujishiro M, Ono H, Kiyonari H, Ishihara H, Asano T.
Sci Rep.   7 13026   2017   [Refereed]
The prolyl isomerase Pin1 increases β-cell proliferation and enhances insulin secretion.
Nakatsu Y, Mori K, Matsunaga Y, Yamamotoya T, Ueda K, Inoue Y, Mitsuzaki-Miyoshi K, Sakoda H, Fujishiro M, Yamaguchi S, Kushiyama A, Ono H, Ishihara H, Asano T.
J Biol Chem.   292 11886-11895   2017   [Refereed]
Efficacy and safety of ipragliflozin as add-on therapy to insulin in Japanese patients with type 2 diabetes mellitus (IOLITE): a multi-centre, randomized, placebo-controlled, double-blind study.
Diabetes Obes Metab.   18 1207-1216   2016   [Refereed]
Is zinc an intra-islet regulator of glucagon secretion?
Ishihara H, Wollheim CB
Diabetol Int   7 106-110   2016
Octreotide for hypoglycemia caused by sulfonylurea and DPP-4 inhibitor
Yamaguchi S, Ikejima M, Furukawa A, Abe M, Nakazaki M, Ishihara H
Diabetes Res Clin Pract   109 e8-e10   2015


Ipragliflozin Add-on Therapy to a GLP-1 Receptor Agonist in Japanese Patients with Type 2 Diabetes (AGATE): A 52-Week Open-Label Study.
Diabetes Ther   9(4) 1549-1567   2018   [Refereed]

Conference Activities & Talks

Overexpression Screening Identifies Mitochondrial Carbonic Anhydrase 5b as an Important Regulator of Glucose-Stimulated Insulin Secretion in Beta Cells
Kosuda M, Yamaguchi S, Nagasawa A, Yamana M, Koike M, Nishioka H, Ishihara H.
79th American Diabetes Association Meeting   10 Jun 2019   
Featured Symposium 2: Future of Diabetes Care
第62回 日本糖尿病学会年次学術集会   21 May 2019   

Research Grants & Projects