1995年3月
IN-VIVO AND IN-VITRO EVIDENCE FOR THE PRODUCTION OF INHIBIN-LIKE IMMUNOREACTIVITY IN HUMAN ADRENOCORTICAL ADENOMAS AND NORMAL ADRENAL-GLANDS - RELATIVELY HIGH SECRETION FROM ADENOMAS MANIFESTING CUSHINGS-SYNDROME
EUROPEAN JOURNAL OF ENDOCRINOLOGY
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- 巻
- 132
- 号
- 3
- 開始ページ
- 292
- 終了ページ
- 299
- 記述言語
- 英語
- 掲載種別
- 出版者・発行元
- SCANDINAVIAN UNIVERSITY PRESS
To clarify whether adrenal gland secretes inhibin in vivo in physiological or pathological conditions, we measured the levels of inhibin-like immunoreactivity (inhibin-LI) in adrenal veins (A-vein) and compared them with those in inferior vena cava (TVC) using blood samples obtained at catheterization of adrenal vein in the patients with adrenal adenoma manifesting Cushing's syndrome (Cs), aldosterone-producing adenoma, clinically non-functioning adenoma and normal adrenal gland. The tumor sides of A-veins in the patients with adenomas and also both sides of A-veins in subjects with normal adrenal glands showed significantly higher contents of inhibin-LI than their NC. When the inhibin-LI secretion rate from adrenal gland was estimated by the difference between the levels of A-vein (tumor side) and TVC, Cs adenomas showed the highest secretion rate. Similarly, the tissue inhibin-LI content and the basal secretion rate of inhibit-LI from primary cultured cells were the highest in Cs adenomas. These findings indicated that normal adrenal glands and adrenocortical adenomas produced and secreted inhibin-LI into the general circulation in vivo and Cs adenomas have relatively high capacity for secreting inhibin-LI, and the present study provided the first in vivo evidence for adrenal inhibin-LI production in pathological conditions.
- リンク情報
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- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/7889177
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:A1995QM32500008&DestApp=WOS_CPL
- URL
- https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0028913721&origin=inward
- ID情報
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- ISSN : 0804-4643
- PubMed ID : 7889177
- SCOPUS ID : 0028913721
- Web of Science ID : WOS:A1995QM32500008