Hiroko Kishi

Profile Information

Affiliation: Professor, Department of Environmental Physiology, Faculty of Medicine, Shimane University

Degree: Doctor (Medicine)(Gunma University)

Researcher number: 40359899
ORCID ID: https://orcid.org/0000-0003-2896-7355
J-GLOBAL ID: 200901018061996766
researchmap Member ID: 5000042979

Research Interests

Research Areas

Research History

May, 2023 - Present

Professor, Faculty of Medicine, Department of Environmental Physiology, Shimane University
Oct, 2011 - Apr, 2023

Associate Professor, Graduate School of Medicine(Medicine), YAMAGUCHI UNIVERSITY
Sep, 2002 - Sep, 2011

Lecturer, Graduate School of Medicine(Medicine), YAMAGUCHI UNIVERSITY

Education

- Mar, 1999

Pharmacology, Graduate School, Division of Medicine, Gunma University
- Mar, 1990

School of Medicine, Faculty of Medicine, Gunma University

Major Papers

The role of calpain activation and vimentin cleavage in the signal transduction of abnormal vascular smooth muscle contraction meditated by SPC/Fyn/ROK pathway

Kishi Hiroko, Lu Qian, Morita Tomoka, Zhang Ying, Lyu Bochao, Zhang Min, Li Nan, Xu Minhui, Kobayashi Sei

The Journal of Physiological Sciences, 70(Suppl.1) S82-S82, Mar, 2020 Lead author

Books and Other Publications

Muscle Contraction and Cell Motility: Fundamentals and Developments

Ying Zhang, Hiroko Kishi, Katsuko Kajiya, Tomoka Morita, Sei Kobayashi (Role: Joint author, Chapter 13, The pivotal role of cholesterol and membrane lipid rafts in the Ca2+-sensitization of vascular smooth muscle contraction leading to vasospasm)

Pan Stanford (2016/11/23), p333 -342, edited by Haruo Sugi, Nov, 2016 (ISBN: 9789814745161)
Molecular Mechanisms of Smooth Muscle Contraction

Kohichi Hayakawa, Hiroko Kishi, Kazuhiro Kohama, Yuan Lin, Akio Nakamura, Tsuyoshi Okagaki, Yinhuan Xue, Li-Hong Ye (Role: Joint author, Chapter 2, The Molecular Anatomy of Myosin Light Chain Kinase)

R. G. Landes Company, 1998 (ISBN: 1570595666)

Major Presentations

321

The role of calpain protease and vimentin cleavage in the signal transduction of abnormal vascular smooth muscle contraction

Hiroko Kishi, Keisuke Shigenobu, Tatsuo Miyamoto

10th Federation of the Asian and Oceanian Physiological Societies (FAOPS) Congress, Nov 3, 2023, Federation of the Asian and Oceanian Physiological Societies (FAOPS) Invited

Research Projects

Elucidation of the mechanism by which paxillin controls vascular abnormal contraction

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2021 - Mar, 2024
中間径フィラメントビメンチンを介した新規血管平滑筋異常収縮シグナル伝達機構の解明

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2020 - Mar, 2023

岸博子, 小林誠, 張影, 森田知佳
疾患エクソソームを新規バイオマーカーとして心疾患の予防・先制医療に挑む

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2020 - Mar, 2023

中村彰男, 岸博子, 河原田律子
Elucidation of the mechanism by which paxillin controls vascular abnormal contraction

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2021

Zhang Ying
New Development of Foods for Preventing Vascular Diseases-Search for Biomarkers for Disease Prevention on the plasma Exosomes-

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2020

Nakamura Akio
新規に同定した細胞接着斑分子paxillinが血管攣縮における役割の解明

科学研究費基盤研究(C), 日本学術振興会, 2018 - 2020

張影
Elucidation of the involvement of calpain and cytoskeletal proteins in the signal transduction of abnormal vascular smooth muscle contraction

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2019

KISHI Hiroko, LYU Bochao, ZHANG Min, LU Qian, LI Nan
Searching for the novel signalling molecule in vascular abnormal contraction

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

ZHANG Ying, KOBAYASHI Sei, KISHI Hiroko
血管平滑筋異常収縮シグナル伝達においてカルパインと細胞骨格が果たす役割の解明

科学研究費基盤研究C, 日本学術振興会, 2016 - 2018

岸博子
血管病予防食品開発の新展開-血漿中エクソソームの疾病予防バイオマーカーの探索-

科学研究費基盤研究(C), 日本学術振興会, 2015 - 2017

中村彰男
The elucidation of preventive mechanism of vasospasm using food factors via membrane microdomain dynamics

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2016

KAJIYA Katsuko, KISHI HIROKO, KOBAYASHI SEI
Elucidation of the shared signaling pathways for intractable diseases in terms of cytoskeletal rearrangements

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2016

KISHI Hiroko, KAJIYA Katsuko, KOBAYASHI Sei, ZHANG Ying
Research for novel signaling molecule involving vascular smooth muscle abnormal contraction

Grants-in-Aid for Scientific Research, Grant-in-Aid for Research Activity Start-up, Japan Society for the Promotion of Science, Aug, 2013 - Mar, 2015

ZHANG Ying, KOBAYASHI Sei, KISHI Hiroko
Elucidation of mechanism for production of causal factor of vasospasm

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2011 - Mar, 2015

KOBAYASHI Sei, KISHI Hiroko
Identification of food component which selectively inhibits abnormal vascular contraction

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2011 - Mar, 2015

KOBAYASHI Sei, KISHI Hiroko, KAJIYA Katsuko, ZHANG Ying
細胞膜ミクロドメインのダイナミクス制御による食品成分の血管攣縮予防メカニズム解明

科学研究費基盤研究(C), 日本学術振興会, 2013 - 2015

加治屋勝子
細胞骨格制御の観点から難病疾患群に共通する病的シグナル伝達系を解明する

科学研究費基盤研究C, 日本学術振興会, 2013 - 2015

岸博子
血管異常収縮を選択的に阻害する食品成分の同定と作用機序の解明

科学研究費補助金基盤研究(B), 日本学術振興会, 2011 - 2013

小林誠
血管攣縮の原因シグナル分子の産生機構の解明

科学研究費挑戦的萌芽研究, 日本学術振興会, 2011 - 2013

小林誠
The elucidation of the relationship between vascular smooth muscle contraction and cytoskeletal rearrangement by proteomics and functional analysis

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2010 - 2012

KISHI Hiroko, KOBAYASHI Sei, KAJIYA Katsuko, KAWAMICHI Hozumi

Awards

Professional Memberships

Committee Memberships

Aug, 2023 - Present

Director, Japan Society of Smooth Muscle Research
Aug, 2011 - Present

Councilor, Japan Society of Smooth Muscle Research
Mar, 2006 - Present

Councilor, The Physiological Society of Japan
Mar, 2004 - Present

Councilor, The Japanese Pharmacological Society
Aug, 2022 - Jul, 2023

Auditor, Japan Society of Smooth Muscle Research
Feb, 2012 - Apr, 2023

Councilor, Yamaguchi Medical Association

Industrial Property Rights

特許6593619 血管攣縮抑制剤

小林誠, 高▲柿▼ 了大, 岸博子, 張影, 加治屋勝子, 渡邉和晃
特許6501353 SPC/Fyn/Rhoキナーゼシグナル伝達経路の阻害剤

岸博子, 小林誠, 張影
特許第6312191号血管弛緩作用を有するペプチド及び血管弛緩剤

小林誠, 木村友彦, 岸博子, 加治屋勝子, 高田雄一, 白土絵理
特開2016-056138 血管攣縮抑制剤

高▼松日出子, 小林誠, 宮成健司, 岸博子, 加治屋勝子, 野地本和孝, 高田雄一
特開2015-051953 血管弛緩作用を有するペプチド及び血管弛緩剤

小林誠, 木村友彦, 岸博子, 加治屋勝子, 高田雄一, 白土絵理
WO2014-073659 高血圧改善又は予防のための経口摂取用組成物

御手洗誠, 織田浩司, 大和田耕司, 古田久美子, 本多倫子, 都丸恵理, 村上祥子, 河村敦子, 稲垣順子, 梅本誠治, 小林誠, 岸博子, 加治屋勝子
特許第5504405号血管病予防に効果を有する食品組成物

小林誠, 岸博子
特許第5186679号血管病予防に効果を有する食品組成物

小林誠, 岸博子
特許第5158715号平滑筋収縮抑制剤

扇谷悟, 森田直樹, 花田啓子, 一瀬香峰子, 小林利克, 小林誠, 岸博子, 宮下和夫, 細川雅史
特許第5124776号平滑筋収縮抑制剤

小林誠, 岸博子, 横地俊弘, 中原東郎, 公文保幸
特許第5103618号血管異常収縮の抑制剤

小林誠, 岸博子, 中島幹夫, 前田祥範
特開2012-102125 血管病予防に効果を有する食品組成物

小林誠, 岸博子
特開2008-214309 血管異常収縮の抑制剤

小林誠, 岸博子, 中島幹夫, 前田祥範
2008-214309 血管異常収縮の抑制剤

小林誠, 岸博子, 中島幹夫, 前田祥範
WO2007-132888 平滑筋収縮抑制剤

扇谷悟, 森田直樹, 花田啓子, 一瀬香峰子, 小林利克, 小林誠, 岸博子, 宮下和夫, 細川雅史
WO2007/132888 平滑筋収縮抑制剤

扇谷悟, 森田直樹, 花田啓子, 小林利克, 小林誠, 岸博子, 宮下和夫, 細川雅史
特開2007-112784 血管病予防に効果を有する食品組成物

小林誠, 岸博子
2007-112784 血管病予防に効果を有する食品組成物

小林誠, 岸博子
WO2006-126712 平滑筋収縮抑制剤

小林誠, 岸博子, 横地俊弘, 中原東郎, 公文保幸

Misc.

121

Peroxisome-primary cilium contact site controls the epithelial tube size via ciliary cholesterol trafficking

板橋岳志, 細羽康介, 森田知佳, 山岡賢治, 木村相泰, 小林大悟, 岸博子, 岸博子, 伊藤浩史, 川上秀史 …

日本分子生物学会年会プログラム・要旨集(Web), 46th, 2023
Germline mutation of the cholesterol-binding site in a mechanosensitive calcium ion channel Polycystin-2 gene

森田知佳, 木村相泰, 岸博子, 細羽康介, 伊藤浩史, 山本卓, 宮本達雄

日本分子生物学会年会プログラム・要旨集(Web), 45th, 2022
Madagascine induces vasodilatation via activation of AMPK(和訳中)

呂博超, Chen Dapeng, Lin Yuan, 張影, 森田知佳, 岸博子, 小林誠

山口医学, 69(3) 155-155, Sep, 2020
血管攣縮と癌細胞遊走の両方を抑制する水溶性の食品成分の発見

豊川絢子, 呂博超, 張影, 張敏, 森田知佳, 岸博子, 小林誠

山口医学, 69(3) 155-155, Sep, 2020
SPC/Fyn/ROK系による血管平滑筋異常収縮のシグナル伝達におけるカルパインの活性化とビメンチン断片化の役割の解明

岸博子, 路倩, 森田知佳, 張影, 呂博超, 張敏, 李楠, 徐敏慧, 小林誠

山口医学, 69(3) 156-156, Sep, 2020 Lead author
History and Up-to-date stories on the mechanism of smooth muscle contraction in health and disease Novel signaling molecules which regulate both Ca2+-sensitization of vascular contraction and cancer cell migration(和訳中)

Kobayashi Sei, Lyu Bochao, Zhang Min, Zhang Ying, Kishi Hiroko, Morita Tomoka

The Journal of Physiological Sciences, 70(Suppl.1) S57-S57, Mar, 2020
Role of paxillin in sphingosylphosphorylcholine (SPC)-induced Ca2+- sensitization contraction of vascular smooth muscle(和訳中)

Zhang Ying, Lyu Bochao, Morita Tomoka, Cui Dan, Kishi Hiroko, Zhang Min, Lu Qian, Li Nan, Ikeda Eiji, Kobayashi Sei

The Journal of Physiological Sciences, 70(Suppl.1) S82-S82, Mar, 2020
Fyn-パキシリン直接結合は冠動脈平滑筋細胞の移動を制御する(Direct Fyn-paxillin binding controls migration of coronary artery smooth muscle cells)

Zhang Ying, Zhang Min, Lyu Bochao, Kishi Hiroko, Morita Tomoka, Lu Qian, Li Nan, Kobayashi Sei

The Journal of Physiological Sciences, 69(Suppl.1) S177-S177, Jun, 2019
SPCおよびU46619誘発の異常な血管平滑筋収縮におけるcalpainの関与(The involvement of calpain in abnormal vascular smooth muscle contraction induced by SPC and U46619)

Kishi Hiroko, Lu Qian, Morita Tomoka, Zhang Ying, Lyu Bochao, Zhang Min, Li Nan, Kobayashi Sei

The Journal of Physiological Sciences, 69(Suppl.1) S206-S206, Jun, 2019
血管攣縮に繋がる腹部血管収縮を選択的に阻害する大豆由来新規化合物の発見(Discovery of novel compound from soybean which selectively inhibits the abnormal vascular contraction leading to vasospasm)

Zhang Min, Zhang Ying, Lyu Bochao, Takagaki Ryodai, Kishi Hiroko, Kajiya Katsuko, Morita Tomoka, Kobayashi Sei

日本生理学雑誌, 81(2) 35-36, May, 2019
血管の異常収縮に対するニンニクの新規機能の発見

小林誠, LYU B., ZHANG M., LU Q., LI N., 平田翔, 執行正義, ZHANG Y., 岸博子, 森田知佳

園芸学研究別冊, 18(2), 2019
食品から発見された、血管攣縮と癌細胞遊走を同時抑制可能な新規の水溶性特効薬成分

浅田充夫, 呂博超, 張敏, 張影, 岸博子, 森田知佳, 小林誠

山口医学, 67(4) 220-220, Dec, 2018
癌細胞遊走を制御する新規シグナル分子の分子機構の解明チロシンリン酸化の重要性

大濱円奈, 張影, 横林志織, 岡本嵩史, 岸博子, 森田知佳, 山本健, 小林誠

山口医学, 67(3) 170-170, Sep, 2018
食品から発見された、血管攣縮と癌細胞遊走を同時抑制可能な新規の水溶性特効薬成分

浅田充夫, 呂博超, 張敏, 張影, 岸博子, 森田知佳, 小林誠

山口医学, 67(3) 170-170, Sep, 2018
チロシンキナーゼFYNが肺動脈高血圧の病態生理に果たす役割

倉原琳, 平石敬三, 張影, 山村彩, 岸博子, 小林誠, 古賀佳織, 鬼塚美樹, 阿部弘太郎, 塩井成留実 …

日本生理学雑誌(Web), 80(2) WEB ONLY, May, 2018
SPC/Fyn/ROK経路を介する血管平滑筋異常収縮のシグナル伝達における膜ラフトの関与第二報(The involvement of membrane rafts in the signal transduction of abnormal vascular smooth muscle contraction mediated by SPC/Fyn/ROK pathway: Part II)

Kishi Hiroko, Kajima Miki, Kajiya Katsuko, Zhang Ying, Morita Tomoka, Lyu Bochao, Zhang Min, Kobayashi Sei

The Journal of Physiological Sciences, 68(Suppl.1) S76-S76, Mar, 2018
新規シグナル伝達分子paxillinのFynを介するチロシンリン酸化は癌細胞のストレスファイバー形成および遊走を制御する(Fyn-mediated tyrosine phosphorylation of a novel signaling molecule, paxillin controls stress fiber formation and migration of cancer cells)

Yokobayashi Shiori, Ying Zhang, Okamoto Takahumi, Morita Tomoka, Kishi Hiroko, Yamamoto Takeshi, Kobayashi Sei

The Journal of Physiological Sciences, 68(Suppl.1) S76-S76, Mar, 2018
Omega-3およびomega-6 docosapentaenoic acid(DPA)はRho-kinase活性化および移動を抑制して異常な血管収縮のCa2感作を等しく抑制する(Omega-3 and omega-6 docosapentaenoic acid(DPA) equally inhibit the Ca2-sensitization abnormal vascular contractions via inhibiting the Rho-kinase activation and translocation)

Zhang Ying, Zhang Min, Lyu Bochao, Kishi Hiroko, Morita Tomoka, Kobayashi Sei

The Journal of Physiological Sciences, 68(Suppl.1) S82-S82, Mar, 2018
大豆から発見された血管異常収縮の特効薬成分

張敏, 張影, 呂博超, 岸博子, 加治屋勝子, 森田知佳, 小林誠

山口医学, 66(4) 237-237, Oct, 2017
癌細胞遊走を制御する新規シグナル分子のチロシンリン酸化の重要性

横林志織, 張影, 岡本嵩史, 岸博子, 森田知佳, 山本健, 小林誠

山口医学, 66(4) 239-239, Oct, 2017

Profile Information

Research Interests

Research Areas

Research History

Education

Major Papers

Books and Other Publications

Major Presentations

Research Projects

Awards

Professional Memberships

Committee Memberships

Industrial Property Rights

Misc.

Teaching Experience

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Coauthors