論文

査読有り
2017年9月

Validation of the revised International Prognostic Scoring System in patients with myelodysplastic syndrome in Japan: results from a prospective multicenter registry

INTERNATIONAL JOURNAL OF HEMATOLOGY
  • Hiroshi Kawabata
  • Kaoru Tohyama
  • Akira Matsuda
  • Kayano Araseki
  • Tomoko Hata
  • Takahiro Suzuki
  • Hidekazu Kayano
  • Kei Shimbo
  • Yuji Zaike
  • Kensuke Usuki
  • Shigeru Chiba
  • Takayuki Ishikawa
  • Nobuyoshi Arima
  • Masaharu Nogawa
  • Akiko Ohta
  • Yasushi Miyazaki
  • Kinuko Mitani
  • Keiya Ozawa
  • Shunya Arai
  • Mineo Kurokawa
  • Akifumi Takaori-Kondo
  • 全て表示

106
3
開始ページ
375
終了ページ
384
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1007/s12185-017-2250-0
出版者・発行元
SPRINGER JAPAN KK

The Japanese National Research Group on Idiopathic Bone Marrow Failure Syndromes has been conducting prospective registration, central review, and follow-up study for patients with aplastic anemia and myelodysplastic syndrome (MDS) since 2006. Using this database, we retrospectively analyzed the prognosis of patients with MDS. As of May 2016, 351 cases were registered in this database, 186 of which were eligible for the present study. Kaplan-Meier analysis showed that overall survival (OS) curves of the five risk categories stipulated by the revised international prognostic scoring system (IPSS-R) were reasonably separated. 2-year OS rates for the very low-, low-, intermediate-, high-, and very high-risk categories were 95, 89, 79, 35, and 12%, respectively. In the same categories, incidence of leukemic transformation at 2 years was 0, 10, 8, 56, and 40%, respectively. Multivariate analysis revealed that male sex, low platelet counts, increased blast percentage (> 2%), and high-risk karyotype abnormalities were independent risk factors for poor OS. Based on these data, we classified Japanese MDS patients who were classified as intermediate-risk in IPSS-R, into the lower risk MDS category, highlighting the need for careful assessment of treatments within low- and high-risk treatment protocols.

リンク情報
DOI
https://doi.org/10.1007/s12185-017-2250-0
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/28497239
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000409072600009&DestApp=WOS_CPL
ID情報
  • DOI : 10.1007/s12185-017-2250-0
  • ISSN : 0925-5710
  • eISSN : 1865-3774
  • PubMed ID : 28497239
  • Web of Science ID : WOS:000409072600009

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