論文

査読有り 国際誌
2018年11月

Interobserver concordance of assessments of dysplasia and blast counts for the diagnosis of patients with cytopenia: From the Japanese central review study.

Leukemia research
  • Akira Matsuda
  • Hiroshi Kawabata
  • Kaoru Tohyama
  • Tomoya Maeda
  • Kayano Araseki
  • Tomoko Hata
  • Takahiro Suzuki
  • Hidekazu Kayano
  • Kei Shimbo
  • Kensuke Usuki
  • Shigeru Chiba
  • Takayuki Ishikawa
  • Nobuyoshi Arima
  • Masaharu Nohgawa
  • Akiko Ohta
  • Yasushi Miyazaki
  • Sinnji Nakao
  • Keiya Ozawa
  • Shunya Arai
  • Mineo Kurokawa
  • Kinuko Mitani
  • Akifumi Takaori-Kondo
  • 全て表示

74
開始ページ
137
終了ページ
143
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.leukres.2018.06.003

The diagnosis of myelodysplastic syndromes (MDS) is based on morphology and cytogenetics. However, limited information is currently available on the interobserver concordance of the assessment of dysplastic lineages (<10% or ≥10% in bone marrow (BM)). The revised International Prognostic Scoring System (IPSS-R) described a new threshold (2%) for BM blasts. However, the interobserver concordance of the categories (0-≤2% and >2-<5%) has limited data. The purpose of the present study was to investigate the assessment of dysplastic lineages and IPSS-R reproducibility. Our study was divided into two Steps. In each Step, the microscopic examinations were performed separately by two morphologists. Regarding the category of BM blasts ≤2% and >2-<5%, interobserver agreement was more than 'moderate' in all pairs (kappa test: 0.43-0.90). Regarding dysgranulopoiesis (dysG) and dyserythropoiesis (dysE) in BM, interobserver agreement was more than 'moderate' in all pairs (kappa test, dysG: 0.45-0.96, dysE: 0.45-0.81). Regarding the category of dysmegakaryopoiesis (dysMgk) in BM, interobserver agreement was more than moderate in 4 out of 5 pairs (kappa test: 0.58-1.00), and was fair for one pair (kappa test: 0.37). We consider that high interobserver concordance may be possible for the BM blast cell count (≤2% or >2-<5%) and dysplasia (<10% or ≥10%) of each lineage.

リンク情報
DOI
https://doi.org/10.1016/j.leukres.2018.06.003
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/29914726
ID情報
  • DOI : 10.1016/j.leukres.2018.06.003
  • ISSN : 0145-2126
  • PubMed ID : 29914726

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