Makoto Hirota

Profile Information

Affiliation: Medical Center, Oral and Maxillofacial Surgery/Orthodontics, Yokohama City University

Degree: 博士（医学）(横浜市立大学)

J-GLOBAL ID: 200901048825780115
researchmap Member ID: 5000044178

External link: http://www.ycu-oms.jp/

2012年UCLAに留学し、多孔質チタン材料の紫外線照射による光機能化効果を実証し、2013年アメリカ口腔外科学会でポスター賞を受賞した。帰国後は研究成果を臨床応用し、2016年アメリカ口腔外科学会においてミニレクチャーを行った。国内では口腔癌術後のインプラントをキーワドとして先進医療獲得を目指している。

Research Interests

Research Areas

Research History

Apr, 2019 - Present

Director/Associate Professor, Department Oral and Maxillofacial Surgery/Orthodontics, Yokohama City University Medical Center
Apr, 2007 - Mar, 2019

Yokohama City University
Apr, 2012 - Sep, 2013

Visiting Scholar, School of Dentistry, University of California, Los Angeles
Oct, 2006 - Mar, 2007

Visiting Scholar, School of Dentistry, Germany, Erlangen-Nuremberg University
Apr, 2005 - Mar, 2007

Yokohama City University
Sep, 2004 - Mar, 2005

Yokohama City University
Apr, 2002 - Aug, 2004

Yokohama City University

Education

Awards

Oct, 2013

E-poster awards, Photofunctionalization enhances osteoconductivity of medical titanium mesh, American academy of oral and maxillofacial surgeons annual meeting

HIROTA Makoto

Major Papers

225

A nitrogen-containing bisphosphonate inhibits osteoblast attachment and osteoconductivity of bone compatible porous scaffold

Koyama C, Hirota M, Okamoto Y, Iwai T, Ogawa T, Hayakawa T, Mitsudo K

J Mech Behav Biomed Mater, 104 103635, Apr, 2020 Peer-reviewed
Tuning of Titanium Microfiber Scaffold with UV-Photofunctionalization for Enhanced Osteoblast Affinity and Function.

Chika Iwasaki, Makoto Hirota, Miyuki Tanaka, Hiroaki Kitajima, Masako Tabuchi, Manabu Ishijima, Wonhee Park, Yoshihiko Sugita, Ken Miyazawa, Shigemi Goto …

International journal of molecular sciences, 21(3), Jan 23, 2020 Peer-reviewed
Computational Fluid Simulation of Fibrinogen around Dental Implant Surfaces.

Hiroaki Kitajima, Makoto Hirota, Toshinori Iwai, Kosuke Hamajima, Ryotaro Ozawa, Yuichiro Hayashi, Yasuharu Yajima, Masaki Iida, Toshiyuki Koizumi, Mitomu Kioi …

International journal of molecular sciences, 21(2), Jan 19, 2020 Peer-reviewed
Impaired osteoblastic behavior and function on saliva-contaminated titanium and its restoration by UV treatment.

Makoto Hirota, Takayuki Ikeda, Yoshihiko Sugita, Manabu Ishijima, Satoko Hirota, Takahiro Ogawa

Materials science & engineering. C, Materials for biological applications, 100 165-177, Jul, 2019 Peer-reviewed
Effect of Photofunctionalization on Early Implant Failure.

Hirota M, Ozawa T, Iwai T, Ogawa T, Tohnai I

The International journal of oral & maxillofacial implants, 33(5) 1098-1102, Sep, 2018 Peer-reviewed
Evaluation of influence factors to reduce mechanical stress on the marginally resected mandibular bone against dental implant-supported occlusion

Naohito Tamai, Makoto Hirota, Toshinori Iwai, Mitomu Kioi, Kenji Mitsudo, Iwai Tohnai

Journal of Hard Tissue Biology, 27(1) 11-16, 2018 Peer-reviewed
Effects of Ultraviolet Photofunctionalization on Bone Augmentation and Integration Capabilities of Titanium Mesh and Implants

Makoto Hirota, Takayuki Ikeda, Masako Tabuchi, Tomomichi Ozawa, Iwai Tohnai, Takahiro Ogawa

INTERNATIONAL JOURNAL OF ORAL & MAXILLOFACIAL IMPLANTS, 32(1) 52-62, Jan, 2017 Peer-reviewed
Implant Stability Development of Photofunctionalized Implants Placed in Regular and Complex Cases: A Case-Control Study

Makoto Hirota, Tomomichi Ozawa, Toshinori Iwai, Takahiro Ogawa, Iwai Tohnai

INTERNATIONAL JOURNAL OF ORAL & MAXILLOFACIAL IMPLANTS, 31(3) 676-686, May, 2016 Peer-reviewed
Effect of Photofunctionalization on Ti6Al4V Screw Stability Placed in Segmental Bone Defects in Rat Femurs.

Makoto Hirota, Miyuki Tanaka, Manabu Ishijima, Chika Iwasaki, Wonhee Park, Takahiro Ogawa

Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 74(4) 861.e1-16-861.e16, Apr, 2016 Peer-reviewed
Bone Generation Profiling Around Photofunctionalized Titanium Mesh

Makoto Hirota, Takayuki Ikeda, Masako Tabuchi, Kaori Nakagawa, Wonhee Park, Manabu Ishijima, Naoki Tsukimura, Yoshiyuki Hagiwara, Takahiro Ogawa

INTERNATIONAL JOURNAL OF ORAL & MAXILLOFACIAL IMPLANTS, 31(1) 73-86, Jan, 2016 Peer-reviewed
Development of a biointegrated mandibular reconstruction device consisting of bone compatible titanium fiber mesh scaffold.

Makoto Hirota, Takaki Shima, Itaru Sato, Tomomichi Ozawa, Toshinori Iwai, Akihiro Ametani, Mitsunobu Sato, Yasuharu Noishiki, Takahiro Ogawa, Tohru Hayakawa …

Biomaterials, 75 223-236, Jan, 2016 Peer-reviewed
High porous titanium scaffolds showed higher compatibility than lower porous beta-tricalcium phosphate scaffolds for regulating human osteoblast and osteoclast differentiation.

Makoto Hirota, Tohru Hayakawa, Takaki Shima, Akihiro Ametani, Iwai Tohnai

Materials science & engineering. C, Materials for biological applications, 49 623-631, Apr, 2015 Peer-reviewed
Effect of ultraviolet-mediated photofunctionalization for bone formation around medical titanium mesh.

Makoto Hirota, Takayuki Ikeda, Masako Tabuchi, Toshinori Iwai, Iwai Tohnai, Takahiro Ogawa

Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 72(9) 1691-702, Sep, 2014 Peer-reviewed
High-dose zoledronic acid narrows the periodontal space in rats

Y. Okamoto, M. Hirota, Y. Monden, S. Murata, C. Koyama, K. Mitsudo, T. Iwai, Y. Ishikawa, I. Tohnai

International Journal of Oral and Maxillofacial Surgery, 42(5) 627-631, May, 2013 Peer-reviewed
The Effect of Hydroxyapatite-Coated Titanium Fiber Web on Human Osteoblast Functional Activity

Makoto Hirota, Tohru Hayakawa, Akihiro Ametani, Yoshinori Kuboki, Mitsunobu Sato, Iwai Tohnai

INTERNATIONAL JOURNAL OF ORAL & MAXILLOFACIAL IMPLANTS, 26(2) 245-250, Mar, 2011 Peer-reviewed
Use of the Molecular Precursor Method to Facilitate Thin Hydroxyapatite Coating of Titanium Fiber Web Scaffold and Enhance Bone Formation: An Experimental Study in Rat Cranial Bone Defects

Makoto Hirota, Tohru Hayakawa, Akihiro Ametani, Yuka Monden, Yasuharu Noishiki, Iwai Tohnai

INTERNATIONAL JOURNAL OF ORAL & MAXILLOFACIAL IMPLANTS, 25(5) 888-892, Sep, 2010 Peer-reviewed
Combination with allogenic bone reduces early absorption of beta-tricalcium phosphate (beta-TCP) and enhances the role as a bone regeneration scaffold. Experimental animal study in rat mandibular bone defects.

Makoto Hirota, Yoshiro Matsui, Nobuyuki Mizuki, Teruki Kishi, Kei Watanuki, Tomomichi Ozawa, Takafumi Fukui, Shihomi Shoji, Makoto Adachi, Yuka Monden …

Dental materials journal, 28(2) 153-61, Mar, 2009 Peer-reviewed
Evaluation of maxillary sinus floor augmentation using mixture of autogenous bone and highly pure porous β-tricalcium phosphate (β-TCP): A preliminary study

Makoto Hirota, Yoshiro Matsui, Nobuyuki Mizuki, Kei Watanuki, Tomomichi Ozawa, Toshinori Lwai, Iwai Tohnai

Journal of Hard Tissue Biology, 18(2) 83-88, 2009 Peer-reviewed
Efficacy of tooth extraction wound protection made of atelocollagen sponge (TRE-641): A pilot study in dogs

Makoto Hirota, Nobuyuki Mizuki, Shinjiro Aoki, Susumu Omura, Kei Watanuki, Tomomichi Ozawa, Toshinori Iwai, Yoshiro Matsui, Iwai Tohnai

Journal of Hard Tissue Biology, 18(2) 89-94, 2009 Peer-reviewed
Management considerations in reconstruction of postablative defects of the mandible: vertical distraction of a scapular bone flap and removable lip support: a case report.

Makoto Hirota, Yoshiro Matsui, Nobuyuki Mizuki, Tomokatsu Saito, Kei Watanuki, Toshinori Iwai, Iwai Tohnai

Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, 106(6) e6-9-9, Dec, 2008 Peer-reviewed
Osteosynthesis and simultaneous irregular trifocal distraction osteogenesis for segmental mandibular defect after tumor ablative surgery: a case report.

Makoto Hirota, Hiroshi Chikumaru, Yoshiro Matsui, Makoto Adachi, Shinjiro Aoki, Kei Watanuki, Tomomichi Ozawa, Toshinori Iwai, Iwai Tohnai

Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, 106(5) 651-5, Nov, 2008 Peer-reviewed

Misc.

Verification of CT-image and dental-model matching errors from metal-artifacts in the fabrication of CAD/CAM splints

今井治樹, 今井治樹, 藤田紘一, 藤田紘一, 山下陽介, 高須曜, 小杉泰史, 遠藤大雅, 宮城島弘貴, 本田康二 …

日本顎変形症学会雑誌, 32(2) 163-163, May, 2022
Two cases using CAD/CAM osteotomy guide for genioplasty

本田康二, 岩井俊憲, 矢島康治, 南山周平, 藤田紘一, 藤田紘一, 今井治樹, 今井治樹, 米満郁男, 小野卓史 …

日本顎変形症学会雑誌, 32(2), 2022
A case of facial asymmetry treated by using CAD/CAM surgical guides with pre-bent locking plates

今井治樹, 今井治樹, 藤田紘一, 藤田紘一, 本田康二, 本田康二, 米満郁男, 久野昌隆, 廣田誠, 光藤健司 …

日本矯正歯科学会大会プログラム・抄録集, 80回 212-212, Nov, 2021
Pleomorphic Adenoma Arising from Heterotopic Salivary Gland Tissue in the Submandibular Region

Toshinori Iwai, Satomi Sugiyama, Hiroaki Kitajima, Makoto Hirota, Kenji Mitsudo

JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 15(2), Feb, 2021
Endoscopically-Assisted Intraoral Resection of Compound Odontoma Arising from the Inferomedial Surface of the Mandibular Ramus using Piezosurgery

Toshinori Iwai, Satomi Sugiyama, Hiroaki Kitajima, Makoto Hirota, Kenji Mitsudo

JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 14(12) ZJ01-ZJ02, Dec, 2020
Endoscopic Removal of a Migrated Fragment of Wire used for Intermaxillary Fixation in Surgical Treatment of Mandibular Fracture

Toshinori Iwai, Satomi Sugiyama, Toshiyuki Koizumi, Makoto Hirota, Kenji Mitsudo

JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 14(11) ZJ1-ZJ2, Nov, 2020
Oral Stings Caused by Sperm Bags of Squid

Toshinori Iwai, Satomi Sugiyama, Hiroaki Kitajima, Makoto Hirota, Kenji Mitsudo

JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 14(10), Oct, 2020
早期口腔癌N0症例に対する磁気法によるセンチネルリンパ節生検の検討

杉山聡美, 岩井俊憲, 泉敏治, 馬場隼一, 小栗千里, 飯田昌樹, 大屋貴志, 小泉敏之, 廣田誠, 來生知 …

第43回日本頭頸部癌学会，金沢, Jun, 2019
Prognostic factors and treatment outcomes of advanced maxillary gingival squamous cell carcinoma treated by intra-arterial infusion chemotherapy concurrent with radiotherapy

Yuichiro Hayashi, Kohei Osawa, Rina Nakakaji, Shuhei Minamiyama, Nobuhide Ohashi, Takashi Ohya, Masaki Iida, Toshinori Iwai, Tomomichi Ozawa, Senri Oguri …

Head and Neck, 41 1777-1784, Jun 1, 2019
下顎歯肉扁平上皮癌治療後早期に肝門部リンパ節転移と腹膜播種性転移を認めた1例

小栗千里, 出田ゆか, 杉山聡美, 林雄一郎, 南山周平, 岩井俊憲, 小泉敏之, 廣田誠, 光藤健司

日本口腔腫瘍学会誌, 31(2) 97-103, Jun, 2019
下顎歯肉扁平上皮癌治療後早期に肝門部リンパ節転移と腹膜播種性転移を認めた1例

小栗千里, 出田ゆか, 杉山聡美, 林雄一郎, 南山周平, 岩井俊憲, 小泉敏之, 廣田誠, 光藤健司

日本口腔腫瘍学会誌, 31(2) 97-103, Jun, 2019
オステオトミーガイド、プレベンドプレートを用いた頭蓋基準の上顎位置決め法の正確度

今井治樹, 大村進, 藤田紘一, 山下陽介, 高須曜, 竹田敦, 矢島康治, 本田康二, 岩井俊憲, 小野卓史 …

日本顎変形症学会雑誌, 29(2) 222-222, May, 2019
早期口腔癌N0症例に対する磁気法による新しいセンチネルリンパ節生検の検討

杉山聡美, 岩井俊憲, 泉敏治, 馬場隼一, 小栗千里, 飯田昌樹, 大屋貴志, 小泉敏之, 廣田誠, 來生知 …

第37回日本口腔腫瘍学会総会・学術大会，長崎, Jan, 2019
局所進行口腔癌に対するcetuximab併用動注化学放射線療法の治療効果と安全性に関する前向き研究

來生知, 林雄一郎, 大屋貴志, 飯田昌樹, 岩井俊憲, 小栗千里, 小泉敏之, 廣田誠, 光藤健司

第37回日本口腔腫瘍学会総会・学術大会，長崎, Jan, 2019
局所進行下顎歯肉扁平上皮癌T4症例に対する逆行性超選択的動注化学放射線療法の検討

小栗千里, 杉山聡美, 林雄一郎, 大橋伸英, 南山周平, 北島大朗, 柴崎麻衣子, 馬場隼一, 大屋貴志, 飯田昌樹 …

第37回日本口腔腫瘍学会総会・学術大会，長崎, Jan, 2019
N0舌癌に対する逆行性超選択的動注化学放射線療法：潜在性頸部リンパ節転移の制御

南山周平, 林雄一郎, 大屋貴志, 飯田昌樹, 岩井俊憲, 小栗千里, 小泉敏之, 廣田誠, 光藤健司, 藤内祝

第63回日本口腔外科学会総会・学術大会, Nov, 2018
唾液腺内視鏡下に摘出した顎下腺腺体内唾石の1例

大澤昂平, 岩井俊憲, 佐久間要, 杉山聡美, 南山周平, 北島大朗, 林雄一郎, 小栗千里, 廣田誠, 藤内祝

日本口腔診断学会雑誌, 31(3) 225-228, Oct, 2018
鼻部に及ぶ進行上顎歯肉癌に対し4経路を用いた逆行性超選択的動注化学放射線療法により原発切除を回避できた1例

小栗千里, 光藤健司, 大橋伸英, 飯田昌樹, 岩井俊憲, 小泉敏之, 廣田誠, 來生知, 海津久, 幡多政治 …

横浜医学, 69(4) 543-548, Oct, 2018
局所進行口腔癌に対するcetuximab併用動注化学放射線療法の安全性と上乗せ効果

來生知, 林雄一郎, 大屋貴志, 飯田昌樹, 岩井俊憲, 小栗千里, 小泉敏之, 廣田誠, 光藤健司, 藤内祝

第42回日本頭頸部癌学会, Jun, 2018
進行舌癌に対する逆行性超選択的動注化学放射線療法の検討－副咽頭間隙再発の予防効果－

小栗千里, 光藤健司, 林雄一郎, 南山周平, 大橋伸英, 北島大朗, 馬場隼一, 大屋貴志, 飯田昌樹, 岩井俊憲 …

第42回日本頭頸部癌学会, Jun, 2018

Presentations

Implant stability development of photofunctionalized implants placed in regular and complex cases: A case-control study.

HIROTA Makoto

98th annual meeting of american association of oral and maxillofacial surgeons, Sep 21, 2016 Invited
ラット大腿骨を用いた紫外線処理光機能化チタンインプラントの骨造成効果の検討

廣田誠

第19回日本顎顔面インプラント学会総会, Nov 28, 2015
紫外線照射が医用チタンメッシュの骨伝導性に及ぼす効果に関する基礎研究．

廣田誠

第18回日本顎顔面インプラント学会総会, Nov 29, 2014
Enhanced bone augmentation by using ultraviolet light mediated photofunctionalized titanium implant and mesh in rat femur model.

HIROTA Makoto

The 24th Interdisciplinary research conference on injectable osteoarticular biomaterials and bone augmentation procedure, May 6, 2014
Development of mandibular reconstruction device made of titanium fiber scaffold.

HIROTA Makoto

21st International Conference on Oral and Maxillofacial Surgery ICOMS201, Oct 22, 2013
Photofunctionalization enhances osteoconductivity of medical titanium mesh.

HIROTA Makoto

95th Annual meeting American Association of Oral and Maxilofacial Surgeon, Oct 2, 2013
Development of mandibular reconstruction device made of titanium fiber scaffold.

HIROTA Makoto

Society for Biomaterials 2013 Annual meeting & exposition, Apr 21, 2013
Photofunctionalization enhances osteoconductivity of medical titanium mesh.

HIROTA Makoto

2013 International Association for Dental Research General Session and Exhibitio, Mar 19, 2013
Development of mandibular reconstruction device made of titanium fiber scaffold.

HIROTA Makoto

2012 Tissue Engineering and Regenerative Medicine,, Sep 5, 2012
Anterior Ridge and Bilateral Sinus Floor Augmentation Using Iliac Bone for the Patients with Severe Atrophy of Maxilla.

Asian academy of osteointegration 2008, 2008
腸骨移植による上顎前方部および上顎洞底部骨造成手術の検討

第３７回日本口腔インプラント学会, 2007

Teaching Experience

口腔外科学 (横浜市立大学、日本大学松戸歯学部、鶴見大学歯学部、明海大学歯学部)

Professional Memberships

Research Projects

持続可能な骨芽細胞接着能を賦与した骨結合型チタン性顎骨再建材料の創製

科学研究費助成事業基盤研究(C), 基盤研究(C), 日本学術振興会, Apr, 2023 - Mar, 2027

廣田誠
Mandibular reconstruction simulation with osseointegrated titaniumu scaffold

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2021

Takasu Hikaru
下顎再建用スキャホールドの骨芽細胞誘導能を最適化する紫外線光触媒効果の基礎的研究

科学研究費, 日本学術振興会, Apr, 2017 - Mar, 2021

廣田誠
Development and application of 3D multi-material block printing technology

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

Maruo Shoji
骨形成促進チタンファイバー綿製ブロックによる顎骨再建シミュレーション

科学研究費, 日本学術振興会, Apr, 2013 - Mar, 2015

廣田誠
Jaw bone regeneration by bone-related protein immobilization to three-dimensional titanium fiber materials

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2011 - Mar, 2014

HAYAKAWA Tohru, FUKUSHIMA Tadao, HIROTA Makoto
骨組織誘導能を賦与したチタンファイバー綿製顎骨再建材料の開発

科学研究費, 日本学術振興会, Apr, 2011 - Mar, 2013

廣田誠
Salivary gland regeneration using titanium fiber scaffold.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, 2011 - 2012

AOKI Shinjiro, HIROTA Makoto
Tissue reaction around the implants coated with cell adhesive protein using the tresyl chloride method.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2010 - 2012

OZAWA Tomomichi, HAYAKAWA Touru, HIROTA Makoto
細胞誘導性を賦与したチタンファイバー綿製顎骨再建用3次元スキャホールドの創成

科学研究費, 日本学術振興会, Apr, 2009 - Mar, 2011

廣田誠
Analysis of stem/progenitor cell in human irradiated salivarygland

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, 2010 - 2011

SATO Yuki, HIROTA Makoto
Development of a training system using virtual reality for oral surgery assisted by the endoscope.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2009 - 2011

MATSUI Yoshiro, TOUNAI Iwai, HIROTA Makoto, TOU Takeshi, KOTANI Kazunori, IWAI Toshinori
Isolation and analysis of salivary gland cancer stem/progenitor cell

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2007 - 2008
Development of osteogenesis promotion method with CD34+ cells

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2007 - 2008

MATSUI Yoshiro, ASAHARA Takayuki, HIROTA Makoto, TOHNAI Iwai
Study of supporting therapy in stepwise surgical treatment for mandibular osteoradionecrosis.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2007 - 2008

AOKI Shinjiro, HIROTA Hirota, TOHUNAI Iwai

Profile Information

Research Interests

Research Areas

Research History

Education

Awards

Major Papers

Misc.

Presentations

Teaching Experience

Professional Memberships

Research Projects

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Coauthors