2013年6月
Protocadherin 17 Regulates Presynaptic Assembly in Topographic Corticobasal Ganglia Circuits
NEURON
- 巻
- 78
- 号
- 5
- 開始ページ
- 839
- 終了ページ
- 854
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.neuron.2013.03.031
- 出版者・発行元
- CELL PRESS
Highly topographic organization of neural circuits exists for the regulation of various brain functions in corticobasal ganglia circuits. Although neural circuit-specific refinement during synapse development is essential for the execution of particular neural functions, the molecular and cellular mechanisms for synapse refinement are largely unknown. Here, we show that protocadherin 17 (PCDH17), one of the nonclustered delta 2-protocadherin family members, is enriched along corticobasal ganglia synapses in a zone-specific manner during synaptogenesis and regulates presynaptic assembly in these synapses. PCDH17 deficiency in mice causes facilitated presynaptic vesicle accumulation and enhanced synaptic transmission efficacy in corticobasal ganglia circuits. Furthermore, PCDH17(-/-) mice exhibit antidepressant-like phenotypes that are known to be regulated by corticobasal ganglia circuits. Our findings demonstrate a critical role for PCDH17 in the synaptic development of specific corticobasal ganglia circuits and suggest the involvement of PCDH17 in such circuits in depressive behaviors.
- リンク情報
- ID情報
-
- DOI : 10.1016/j.neuron.2013.03.031
- ISSN : 0896-6273
- PubMed ID : 23684785
- Web of Science ID : WOS:000320743400011