2020年2月
Three-component, one-pot tandem Sonogashira/Suzuki-Miyaura coupling reactions for the synthesis of a library of ceramide-transport protein inhibitors that were designed in silico
Asian Journal of Organic Chemistry
- ,
- ,
- ,
- 巻
- 9
- 号
- 2
- 開始ページ
- 267
- 終了ページ
- 273
- 記述言語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1002/ajoc.201900689
© 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim We have developed a one-pot, tandem Sonogashira/Suzuki-Miyaura coupling reaction, which was unknown synthetically, and applied it for the synthesis of a library of potential natural ligand nonmimetic inhibitors of the lipid-transfer protein, ceramide-transport protein (CERT). The characteristic feature of this reaction is that the two-step coupling reaction proceeds smoothly with only 5 mol% of palladium catalyst. Furthermore, the location of the formed carbon−carbon bond would be strictly defined because of the difference in reactivity. Therefore, many derivatives could be synthesized in high yields without the formation of regioisomeric byproducts by the same procedure. We also performed a semi-gram scale synthesis of several derivatives to provide the bioactive assay. After synthesizing as many as 113 derivatives, we identified a non-natural mimetic inhibitor with activity comparable to that of the known inhibitor (1R,3S)-HPA-12.
- リンク情報
- ID情報
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- DOI : 10.1002/ajoc.201900689
- ISSN : 2193-5807
- SCOPUS ID : 85078785991