論文

査読有り 国際誌
2023年4月11日

Practical Antibody Recruiting by Metabolic Labeling with Caged Glycans.

Angewandte Chemie (International ed. in English)
  • Hersa Milawati
  • ,
  • Yoshiyuki Manabe
  • ,
  • Takuya Matsumoto
  • ,
  • Masato Tsutsui
  • ,
  • Yoshihiro Ueda
  • ,
  • Ayane Miura
  • ,
  • Kazuya Kabayama
  • ,
  • Koichi Fukase

開始ページ
e202303750
終了ページ
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1002/anie.202303750

We propose a de novo glycan display that combines metabolic labeling and a glycan-caging strategy as a facile editing method for cell-surface glycans. This method enables the introduction of antigen glycans onto cancer cells to induce immune responses through antibody recruiting. The caging strategy prevents the capture of α-rhamnose (an antigen glycan) by their endogenous antibodies during the introduction of the glycan to the targeted cell surface, and subsequent uncaging successfully induces immune responses. Therefore, this study proposes a practical method for editing the cell-surface glycocalyx under promiscuous conditions, such as those in vivo, which paves the way for the development of glycan function analysis and regulation.

リンク情報
DOI
https://doi.org/10.1002/anie.202303750
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/37042088
ID情報
  • DOI : 10.1002/anie.202303750
  • PubMed ID : 37042088

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