2023年4月11日
Practical Antibody Recruiting by Metabolic Labeling with Caged Glycans.
Angewandte Chemie (International ed. in English)
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- 開始ページ
- e202303750
- 終了ページ
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1002/anie.202303750
We propose a de novo glycan display that combines metabolic labeling and a glycan-caging strategy as a facile editing method for cell-surface glycans. This method enables the introduction of antigen glycans onto cancer cells to induce immune responses through antibody recruiting. The caging strategy prevents the capture of α-rhamnose (an antigen glycan) by their endogenous antibodies during the introduction of the glycan to the targeted cell surface, and subsequent uncaging successfully induces immune responses. Therefore, this study proposes a practical method for editing the cell-surface glycocalyx under promiscuous conditions, such as those in vivo, which paves the way for the development of glycan function analysis and regulation.
- ID情報
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- DOI : 10.1002/anie.202303750
- PubMed ID : 37042088