Feb, 2021
Plasma Arginase-1 Level Is Associated with the Mental Status of Outpatients with Chronic Liver Disease
DIAGNOSTICS
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- Volume
- 11
- Number
- 2
- Language
- English
- Publishing type
- Research paper (scientific journal)
- DOI
- 10.3390/diagnostics11020317
- Publisher
- MDPI
While plasma arginase-1 has been suggested as a biomarker of mental status in healthy individuals, it has not been evaluated in patients with chronic liver disease. This cross-sectional study investigated the utility of plasma arginase-1 for screening mental status in patients with chronic liver disease. This study included outpatients with chronic liver disease who underwent regular check-ups at Okayama University Hospital between September 2018 and January 2019. In addition to the standard blood tests, the plasma arginase-1 level was analyzed. The patients' mental status was assessed using the Japanese version of the General Health Questionnaire-28 (GHQ-28). The associations between mental status and various parameters, including plasma arginase-1, were investigated using logistic regression analysis. Among 114 participating patients, 8 were excluded, comprising 6 with insufficient blood samples for plasma arginase-1 measurement and 2 with incomplete questionnaires. Multivariate binomial logistic regression analysis revealed that plasma arginase-1 was significantly and negatively associated with the GHQ-total score, especially somatic symptoms. Therefore, plasma arginase-1 may be a useful biomarker for assessing the mental status of outpatients with chronic liver disease.
- Link information
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- DOI
- https://doi.org/10.3390/diagnostics11020317
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/33669265
- PubMed Central
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7920070
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000622461400001&DestApp=WOS_CPL
- Scopus
- https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85108816115&origin=inward Open access
- Scopus Citedby
- https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85108816115&origin=inward
- ID information
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- DOI : 10.3390/diagnostics11020317
- eISSN : 2075-4418
- Pubmed ID : 33669265
- Pubmed Central ID : PMC7920070
- SCOPUS ID : 85108816115
- Web of Science ID : WOS:000622461400001