Jul, 2011
Olmesartan reduces arterial stiffness and serum adipocyte fatty acid-binding protein in hypertensive patients
HEART AND VESSELS
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- Volume
- 26
- Number
- 4
- First page
- 408
- Last page
- 413
- Language
- English
- Publishing type
- Research paper (scientific journal)
- DOI
- 10.1007/s00380-010-0060-x
- Publisher
- SPRINGER
Adipocyte fatty acid binding protein (A-FABP) has been reported to be involved in insulin resistance, lipid metabolism, and atherosclerosis; however, little is known about the effect of medication on the change in circulating A-FABP in human subjects. We evaluated the effects of angiotensin II type 1 receptor blocker (ARB) on arterial stiffness and its association with serum A-FABP in patients with hypertension. Thirty patients newly diagnosed with essential hypertension were treated with olmesartan (20 mg/day), an ARB, for 6 months. Serum levels of A-FABP and high-sensitivity C-reactive protein (hsCRP) were examined and the cardio-ankle vascular index (CAVI), which is a marker of arterial stiffness, was also determined. Serum A-FABP at baseline was significantly correlated with the body mass index (r = 0.45, P = 0.01), homeostasis model assessment as a marker of insulin resistance (r = 0.53, P < 0.01), and systolic blood pressure (r = 0.37, P = 0.047), and tended to be correlated with low-density lipoprotein cholesterol, triglyceride, and CAVI. Olmesartan treatment resulted in a significant decrease in CAVI, serum A-FABP levels, and hsCRP, besides a significant reduction of blood pressure. Multiple regression analysis revealed that the change in CAVI was independently correlated with the change in serum A-FABP. Olmesartan ameliorated arterial stiffness in patients with hypertension, which may be involved in the reduction of serum A-FABP.
- Link information
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- DOI
- https://doi.org/10.1007/s00380-010-0060-x
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/21063874
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000292606800008&DestApp=WOS_CPL
- Scopus
- https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=80051471966&origin=inward
- Scopus Citedby
- https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=80051471966&origin=inward
- ID information
-
- DOI : 10.1007/s00380-010-0060-x
- ISSN : 0910-8327
- eISSN : 1615-2573
- Pubmed ID : 21063874
- SCOPUS ID : 80051471966
- Web of Science ID : WOS:000292606800008