論文

査読有り 責任著者 国際誌
2019年1月

Surface plasma treatment and phosphorylation enhance the biological performance of poly(ether ether ketone)

Colloids and Surfaces B: Biointerfaces
  • Naoyuki Fukuda
  • ,
  • Akira Tsuchiya
  • ,
  • Sunarso
  • ,
  • Riki Toita
  • ,
  • Kanji Tsuru
  • ,
  • Yoshihide Mori
  • ,
  • Kunio Ishikawa

173
開始ページ
36
終了ページ
42
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.colsurfb.2018.09.032
出版者・発行元
Elsevier {BV}

Poly(ether ether ketone) (PEEK) has emerged as an alternative endosseous material to metal implants mainly because of its lack of allergic sensitivity and radiolucency, while maintaining similar mechanical properties with bone. However, a disadvantage of PEEK is its weak osseointegration ability compared with metal implants. To overcome this, we prepared a phosphate group-modified PEEK by plasma treatment and subsequent phosphorylation reaction. Plasma treatment and phosphate modification of PEEK changed its hydrophobic surface to a hydrophilic surface while maintaining the original surface topography and roughness. Phosphate modification increased the bioactivity of rat bone marrow stromal cells (BMSCs), including proliferation, alkaline phosphatase activity, and bone-like nodule formation; however, this effect was negligible in plasma-treated PEEK. In addition, phosphate modification attenuated the phenotypic polarization of lipopolysaccharide-primed RAW264.7 macrophages to an inflammatory phenotype, based on the finding that macrophages on phosphate-modified PEEK produced decreased levels of the inflammatory cytokine and increased levels of the anti-inflammatory cytokine. Finally, in an animal study, phosphate-modified PEEK exhibited a doubled pullout force from the femur bone cavity compared with bare PEEK. Thus, we conclude that phosphate modification can significantly improves the implant-bone bonding strength of PEEK by enhancing BMSCs activity and reducing excessive inflammation.

リンク情報
DOI
https://doi.org/10.1016/j.colsurfb.2018.09.032
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/30266018
URL
http://orcid.org/0000-0001-9700-4531
Scopus
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85053869217&origin=inward
Scopus Citedby
https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85053869217&origin=inward
ID情報
  • DOI : 10.1016/j.colsurfb.2018.09.032
  • ISSN : 0927-7765
  • eISSN : 1873-4367
  • ORCIDのPut Code : 48300186
  • PubMed ID : 30266018
  • SCOPUS ID : 85053869217

エクスポート
BibTeX RIS