論文

査読有り 国際誌
2020年2月1日

Kinetic volume analysis on dynamic contrast-enhanced MRI of triple-negative breast cancer: associations with survival outcomes.

The British journal of radiology
  • Yoko Hayashi
  • ,
  • Hiroko Satake
  • ,
  • Satoko Ishigaki
  • ,
  • Rintaro Ito
  • ,
  • Mariko Kawamura
  • ,
  • Hisashi Kawai
  • ,
  • Shingo Iwano
  • ,
  • Shinji Naganawa

93
1106
開始ページ
20190712
終了ページ
20190712
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1259/bjr.20190712

OBJECTIVE: To evaluate the associations between computer-aided diagnosis (CAD)-generated kinetic volume parameters and survival in triple-negative breast cancer (TNBC) patients. METHODS: 40 patients with TNBC who underwent pre-operative MRI between March 2008 and March 2014 were included. We analyzed CAD-generated parameters on dynamic contrast-enhanced MRI, visual MRI assessment, and histopathological data. Cox proportional hazards models were used to determine associations with survival outcomes. RESULTS: 12 of the 40 (30.0%) patients experienced recurrence and 7 died of breast cancer after a median follow-up of 73.6 months. In multivariate analysis, higher percentage volume (%V) with more than 200% initial enhancement rate correlated with worse disease-specific survival (hazard ratio, 1.12; 95% confidence interval, 1.02-1.22; p-value, 0.014) and higher %V with more than 100% initial enhancement rate followed by persistent curve type at 30% threshold correlated with worse disease-specific survival (hazard ratio, 1.33; 95% confidence interval, 1.10-1.61; p-value, 0.004) and disease-free survival (hazard ratio, 1.27; 95% confidence interval, 1.12-1.43; p-value, 0.000). CONCLUSION: CAD-generated kinetic volume parameters may correlate with survival in TNBC patients. Further study would be necessary to validate our results on larger cohorts. ADVANCES IN KNOWLEDGE: CAD generated kinetic volume parameters on breast MRI can predict recurrence and survival outcome of patients in TNBC. Varying the enhancement threshold improved the predictive performance of CAD generated kinetic volume parameter.

リンク情報
DOI
https://doi.org/10.1259/bjr.20190712
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/31821036
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7055451
ID情報
  • DOI : 10.1259/bjr.20190712
  • ISSN : 0007-1285
  • PubMed ID : 31821036
  • PubMed Central 記事ID : PMC7055451

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