論文

査読有り
2017年6月

Reduction in chromosome mobility accompanies nuclear organization during early embryogenesis in Caenorhabditis elegans

Scientific Reports
  • Ritsuko Arai
  • ,
  • Takeshi Sugawara
  • ,
  • Yuko Sato
  • ,
  • Yohei Minakuchi
  • ,
  • Atsushi Toyoda
  • ,
  • Kentaro Nabeshima
  • ,
  • Hiroshi Kimura
  • ,
  • Akatsuki Kimura

7
3631
開始ページ
1
終了ページ
10
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1038/s41598-017-03483-5
出版者・発行元
NATURE PUBLISHING GROUP

In differentiated cells, chromosomes are packed inside the cell nucleus in an organised fashion. In contrast, little is known about how chromosomes are packed in undifferentiated cells and how nuclear organization changes during development. To assess changes in nuclear organization during the earliest stages of development, we quantified the mobility of a pair of homologous chromosomal loci in the interphase nuclei of Caenorhabditis elegans embryos. The distribution of distances between homologous loci was consistent with a random distribution up to the 8-cell stage but not at later stages. The mobility of the loci was significantly reduced from the 2-cell to the 48-cell stage. Nuclear foci corresponding to epigenetic marks as well as heterochromatin and the nucleolus also appeared around the 8-cell stage. We propose that the earliest global transformation in nuclear organization occurs at the 8-cell stage during C. elegans embryogenesis.

Web of Science ® 被引用回数 : 4

リンク情報
DOI
https://doi.org/10.1038/s41598-017-03483-5
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/28623274
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000403415200001&DestApp=WOS_CPL

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