1996年12月
Isolation of a novel chick homolog of Serrate and its coexpression with C-Notch-1 in chick development
INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY
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- 巻
- 40
- 号
- 6
- 開始ページ
- 1089
- 終了ページ
- 1096
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- 出版者・発行元
- UNIV BASQUE COUNTRY PRESS
Intercellular signaling mediated by the transmembrane proteins, Notch as receptor and its ligands, Delta and Serrate, plays essential roles in the developmental fate decision of many cell types in Drosophila. The Notch genes are highly conserved both in invertebrates and in vertebrates, suggesting that Notch pathway regulates cell fate decisions during vertebrates development. Notch, Delta and Serrate homologs in chicken have been cloned (Henrique et al., Nature 375: 787-790, 1995; Myat ef al., Dev. Biol. 174: 233-247, 1996). We isolated a novel chick homolog of Drosophila Serrate, named C-Serrate-2, and examined its expression patterns during the early chick development using whole-mount in situ hybridization. C-Serrate-2 transcripts were detected in several tissues including the forebrain, the myotome and the apical ectodermal ridge (AER) of the limb bud of a 4-day-old chick embryo. In most of the regions where C-Serrate-2 was expressed, C-Notch-1 was also expressed. Our observations suggest that Serrate-2-Notch-1 signaling plays a role in a variety of morphogeneses during the chick development.
- リンク情報
- ID情報
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- ISSN : 0214-6282
- PubMed ID : 9032014
- Web of Science ID : WOS:A1996WC12800003