Yukio Kawahara

Profile Information

Affiliation: 教授, 医学系研究科医学専攻, 大阪大学

Degree: 博士（医学）(東京大学)

J-GLOBAL ID: 201801013705404596
researchmap Member ID: B000310467

External link: http://www.med.osaka-u.ac.jp/pub/rna/p_kawahara.html

神経内科医として、神経変性疾患、特に筋萎縮性側索硬化症 (ALS)の病態解明と治療法の確立を目指して研究をしています。また、RNA生物学も深く探求しています。特に、RNA編集やRNA修飾の生理的意義を明らかにする研究を行っています。

Research Interests

Research Areas

Research History

Apr, 2014 - Present

Professor, Department of RNA Biology and Neuroscience, Graduate School of Medicine, Osaka University
Apr, 2013 - Mar, 2014

Associate Professor, Laboratory of RNA function, Graduate School of Medicine, Osaka University
Dec, 2008 - Mar, 2013

Associate Proessor (tenura-track), Laboratory of RNA function, Graduate School of Medicine, Osaka University
Jun, 2004 - Nov, 2008

Postdoctoral fellow, Nishikura's laboratory, The Wistar Institute
Apr, 2004 - May, 2004

JSPS postdoctoral fellow, Department of Neurology, The University of Tokyo Hospital
Jun, 1995 - Mar, 2000

Clinician, Department of Neurology, The University of Tokyo Hospital and its related hospitals

Education

Apr, 2000 - Mar, 2004

PhD student, Graduate School of Medicine, The University of Tokyo
Apr, 1989 - Mar, 1995

Department of Medicine, The University of Tokyo

Papers

A cancer-associated METTL14 mutation induces aberrant m6A modification, affecting tumor growth

Kotaro Miyake, Pedro Henrique Costa Cruz, Izumi Nagatomo, Yuki Kato, Daisuke Motooka, Shingo Satoh, Yuichi Adachi, Yoshito Takeda, Yukio Kawahara, Atsushi Kumanogoh

Cell Reports, 42(7) 112688-112688, Jun, 2023 Peer-reviewedCorresponding author
RNA editing of AZIN1 coding sites is catalyzed by ADAR1 p150 after splicing

Yanfang Xing, Taisuke Nakahama, Yuke Wu, Maal Inoue, Jung In Kim, Hiroyuki Todo, Toshiharu Shibuya, Yuki Kato, Yukio Kawahara

Journal of Biological Chemistry, 299(7) 104840-104840, May, 2023 Peer-reviewedLast authorCorresponding author
The RNA-editing enzyme ADAR1: a regulatory hub that tunes multiple dsRNA-sensing pathways

Taisuke Nakahama, Yukio Kawahara

International Immunology, 35(3) 123-133, Dec 5, 2022 Peer-reviewedInvitedLast authorCorresponding author
The N6-methyladenosine methyltransferase METTL16 enables erythropoiesis through safeguarding genome integrity

Masanori Yoshinaga, Kyuho Han, David W. Morgens, Takuro Horii, Ryosuke Kobayashi, Tatsuaki Tsuruyama, Fabian Hia, Shota Yasukura, Asako Kajiya, Ting Cai …

Nature Communications, 13(1) 6435-6435, Oct 28, 2022 Peer-reviewed
Alignment of single-cell trajectory trees with CAPITAL

Reiichi Sugihara, Yuki Kato, Tomoya Mori, Yukio Kawahara

Nature Communications, 13(1) 5972, Oct 14, 2022 Peer-reviewedLast author
An Aicardi-Goutières Syndrome–Causative Point Mutation in Adar1 Gene Invokes Multiorgan Inflammation and Late-Onset Encephalopathy in Mice

Maal Inoue, Taisuke Nakahama, Ryuichiro Yamasaki, Toshiharu Shibuya, Jung In Kim, Hiroyuki Todo, Yanfang Xing, Yuki Kato, Eiichi Morii, Yukio Kawahara

The Journal of Immunology, 207(12) 3016-3027, Nov 12, 2021 Peer-reviewedLast authorCorresponding author
Deciphering the Biological Significance of ADAR1–Z-RNA Interactions

Taisuke Nakahama, Yukio Kawahara

International Journal of Molecular Sciences, 22(21) 11435, Oct, 2021 Peer-reviewedInvitedLast authorCorresponding author
Mutations in the adenosine deaminase ADAR1 that prevent endogenous Z-RNA binding induce Aicardi-Goutières-syndrome-like encephalopathy

Taisuke Nakahama, Yuki Kato, Toshiharu Shibuya, Maal Inoue, Jung In Kim, Tuangtong Vongpipatana, Hiroyuki Todo, Yanfang Xing, Yukio Kawahara

Immunity, 54(9) 1976-1988.e7, Sep, 2021 Peer-reviewedLast authorCorresponding author
Dimethylarginine dimethylaminohydrolase 1 as a novel regulator of oligodendrocyte differentiation in the central nervous system remyelination

Akiko Uyeda, Lili Quan, Yuki Kato, Nagaaki Muramatsu, Shogo Tanabe, Kazuhisa Sakai, Noritaka Ichinohe, Yukio Kawahara, Tatsunori Suzuki, Rieko Muramatsu

Glia, 69(11) 2591-2604, Jul 16, 2021 Peer-reviewed
RNA editing at a limited number of sites is sufficient to prevent MDA5 activation in the mouse brain

Jung In Kim, Taisuke Nakahama, Ryuichiro Yamasaki, Pedro Henrique Costa Cruz, Tuangtong Vongpipatana, Maal Inoue, Nao Kanou, Yanfang Xing, Hiroyuki Todo, Toshiharu Shibuya …

PLOS Genetics, 17(5) e1009516-e1009516, May 13, 2021 Peer-reviewedLast authorCorresponding author
Age-dependent decline in remyelination capacity is mediated by apelin–APJ signaling

Masumi Ito, Rieko Muramatsu, Yuki Kato, Bikram Sharma, Akiko Uyeda, Shogo Tanabe, Harutoshi Fujimura, Hiroyasu Kidoya, Nobuyuki Takakura, Yukio Kawahara …

Nature Aging, 1(3) 284-294, Mar, 2021 Peer-reviewed
RNA Editing in Neurological and Neurodegenerative Disorders

Pedro Henrique Costa Cruz, Yukio Kawahara

Methods in Molecular Biology, 2181 309-330, 2021 Peer-reviewedInvitedLast authorCorresponding author
ADAR1 Regulates Early T Cell Development via MDA5-Dependent and -Independent Pathways.

Vongpipatana T, Nakahama T, Shibuya T, Kato Y, Kawahara Y

The Journal of Immunology, 204(8) 2156-2168, Mar 13, 2020 Peer-reviewedLast authorCorresponding author
Adenosine-to-inosine RNA editing in the immune system: friend or foe?

Taisuke Nakahama, Yukio Kawahara

Cellular and Molecular Life Sciences, 77(15) 2931-2948, Jan 29, 2020 Peer-reviewedInvitedLast authorCorresponding author
Bivartect: accurate and memory-saving breakpoint detection by direct read comparison

Keisuke Shimmura, Yuki Kato, Yukio Kawahara

Bioinformatics, 36(9) 2725-2730, Jan 27, 2020 Peer-reviewedLast author
A comparative analysis of ADAR mutant mice reveals site-specific regulation of RNA editing

Pedro Henrique Costa Cruz, Yuki Kato, Taisuke Nakahama, Toshiharu Shibuya, Yukio Kawahara

RNA, 26(4) 454-469, Jan 15, 2020 Peer-reviewedLast authorCorresponding author
ADAR1-mediated RNA editing is required for thymic self-tolerance and inhibition of autoimmunity.

Taisuke Nakahama, Yuki Kato, Jung In Kim, Tuangtong Vongpipatana, Yutaka Suzuki, Carl R Walkley, Yukio Kawahara

EMBO reports, 19(12) e46303, Dec, 2018 Peer-reviewedLast authorCorresponding author
Quantification of methylation efficiency at a specific N6-methyladenosine position in rRNA by using BNA probes.

Oshima T, Ishiguro K, Suzuki T, Kawahara Y

Chemical Communications (Camb), 54(69) 9627-9630, Aug, 2018 Peer-reviewedLast authorCorresponding author
Myotube-derived factor promotes oligodendrocyte precursor cell proliferation

Akino Nakasone, Rieko Muramatsu, Yuki Kato, Yukio Kawahara, Toshihide Yamashita

Biochemical and Biophysical Research Communications, 500(3) 609-613, Jun 7, 2018 Peer-reviewed
RNA editing independently occurs at three mir-376a-1 sites and may compromise the stability of the microRNA hairpin

Alicia Gallego, Diego A. Hartasanchez, Marina Braso-Vives, Eva Garcia-Ramallo, Maria Lopez-Valenzuela, Neus Baena, Miriam Guitart, Hugo Fernandez-Bellon, Ivanela Kondova, Ronald Bontrop …

GENE, 628 109-116, Sep, 2017 Peer-reviewed

Misc.

N/A

Clinical Neuroscience, 41(5) 684-686, May, 2023 Lead authorLast authorCorresponding author
Type I interferonopathies caused by dysregulation of RNA metabolism

Taisuke Nakahama, Yukio Kawahara

40(15) 2505-2512, Sep, 2022 InvitedLast authorCorresponding author
RNA editing: its physiological functions and application to gene modification technology

Yukio Kawahara

40(12) 1952-1958, Jul, 2022 InvitedLead authorLast authorCorresponding author
Left-handed RNA as a novel molecular pattern recognized by innate immune system

Yukio Kawahara

Clinical Immunology & Allergology, 78(1) 111-117, Jul, 2022 InvitedLead authorLast authorCorresponding author
Reduced RNA editing activity of ADAR1 p150 induces Aicardi-Goutières syndrome-like symptoms in mice

Taisuke Nakahama, Yukio Kawahara

Clinical Immunology & Allergology, 77(6) 737-743, Jun, 2022 InvitedLast authorCorresponding author
RNAの巻き方を感知する自己免疫システム

中濱泰祐, 河原行郎

実験医学, 40(4) 544-549, Mar, 2022 InvitedLast authorCorresponding author
RNA編集を応用した核酸医薬開発の展望

河原行郎

実験医学増刊号, 39(17) 2772-2778, Oct, 2021 Lead authorLast authorCorresponding author
epitranscriptome

Yukio Kawahara

28(6) 546-550, Nov, 2020 InvitedLead authorLast authorCorresponding author
CLIP法とその改良法によるタンパク質結合RNAの高解像度解析

河原行郎

実験医学(別冊), 149-158, 2016
RNA代謝異常を介した神経変性疾患の発症病態

余越萌, 河原行郎

ファルマシア, 51(1) 37-41, 2015
神経変性疾患の発症メカニズムUp-to-Date

河原行郎

BIO Clinica, 30(7) 705-708, 2015
マイクロRNA

余越萌, 河原行郎

生体の科学, 66(5) 478-479, 2015
神経疾患をmicroRNAで診断する

河原行郎

Clinical Neuroscience, 33(11) 1302-1304, 2015
自己免疫疾患とRNA編集

三宅浩太郎, 中濱泰祐, 河原行郎

実験医学(増刊), 33(20) 3339-3344, 2015
神経変性疾患関連タンパク質Ataxin-2は3’非翻訳領域にある特定の配列に直接結合することによって、mRNAの安定性を促進しタンパク質発現を増加させる

余越萌, 河原行郎

ライフサイエンス新着論文レビュー, Jul, 2014 Invited
RNA疾患研究の新展開

河原行郎, 塩見美喜子

Medical Science Digest 臨時増刊号 RNA疾患 (河原行郎・塩見美喜子編輯), 40(7) 324-325, 2014
RNA代謝と神経変性

植村有里, 河原行郎

Brain Medical, 26(3) 209-215, 2014
神経変性疾患に関連するタンパク質Ataxin-2は3’側非翻訳領域に直接に結合することによりmRNAの安定性を促進する

余越萌, 河原行郎

新着論文レビュー, e9044-e9044, 2014
Response to the letter by devaux et al

Yasuhiko Sakata, Sen Matsumoto, Toshimitsu Hamasaki, Yukio Kawahara, Issei Komuro

Circulation Research, 113(5) e48-e49, Aug 16, 2013
microRNAの修飾とその機能― RNA編集，メチル化，アデニル化，ウリジル化

余越萌, 河原行郎

実験医学, 第31巻(第7号(増刊)) 160-167, Apr, 2013 Invited

Books and Other Publications

Post-transcriptional gene regulation by an Editor: ADAR and its role in RNA Editing.

Valente L, Kawahara Y, Zinshteyn B, Iizasa H, Nishikura K (Role: Joint author)

Wiley-VCH book, Apr, 2013 (ISBN: 9783527322022)

Professional Memberships

Apr, 2022 - Present

The RNA Society
Mar, 2022 - Present

The American Association of Immunologists
THE JAPANESE SOCIETY OF INTERNAL MEDICINE
THE JAPANESE SOCIETY FOR IMMUNOLOGY
THE RNA SOCIETY OF JAPAN
THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
THE JAPAN NEUROSCIENCE SOCIETY
JAPANESE SOCIETY OF NEUROLOGY

Research Projects

RNA編集不全に起因する自己免疫性脳症発症メカニムズの解明

科学研究費助成事業基盤研究(B), 基盤研究(B), 日本学術振興会, Apr, 2023 - Mar, 2026

河原行郎
修飾塩基を含むRNAの二次構造解析技術の確立

科学研究費助成事業, 基盤研究(B), 日本学術振興会, Apr, 2022 - Mar, 2025

佐藤健吾, 加藤有己, 河原行郎
RNA編集酵素ADAR1の脳特異的機能の解明

科学研究費助成事業, 基盤研究(B), 日本学術振興会, Apr, 2020 - Mar, 2023

河原行郎, 加藤有己
RNA secondary structure prediction using nanopore sequencers

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2022
Establishment of the mothod for RNA labelling in a neuron subtype-specific manner in vivo

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Research (Exploratory), Japan Society for the Promotion of Science, Jun, 2019 - Mar, 2021

Kawahara Yukio
Establishment of the mothod to quantify methylation efficiency at a specific site

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Research (Exploratory), Japan Society for the Promotion of Science, Jun, 2017 - Mar, 2019

Kawahara Yukio
Eluciadation of the mechanism underlying selective neuronal death mediated by dysregulation of RNA-binding proteins

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2019

Kawahara Yukio
Exploration for microRNAs to predict prognosis in ishemic heart failure

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

SAKATA YASUHIKO
Structural basis of transcriptional repression by SRA, a long non-coding RNA

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

MISHIMA Masaki
非コードRNAとの結合を介したMediator複合体による転写制御機構の解明

科学研究費助成事業, 新学術領域研究(研究領域提案型), 日本学術振興会, Apr, 2015 - Mar, 2017

河原行郎
Elucidation of Ataxin-2-mediated neurodegeneration

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2016

Kawahara Yukio
ALSと脊髄小脳変性症に共通した発症病態の解明

科学研究費助成事業, 新学術領域研究(研究領域提案型), 日本学術振興会, Apr, 2013 - Mar, 2015

河原行郎
The biological significance of the cleavage of ALS-associated protein TDP-43

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2015

KAWAHARA Yukio
ＡＬＳの病態解明に向けたＲＮＡ結合蛋白質ＴＤＰ－４３及びＦＵＳの網羅的機能解析

科学研究費助成事業, 新学術領域研究(研究領域提案型), 日本学術振興会, Apr, 2011 - Mar, 2013

河原行郎
マイクロRNA制御異常を介した筋萎縮性側索硬化症発症病態の解明

科学研究費助成事業, 特別研究員奨励費, 日本学術振興会, 2011 - 2013

河原行郎, LI Quan
Challenge for the identification of ALS-related viruses

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, 2011 - 2012

KAWAHARA Yukio
Elucidation of the role of TDP-43 in microRNA biogenesis and ALS pathogenesis

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2010 - 2012

KAWAHARA Yukio
アミノ酸配列の置換を生じるRNA編集の生理的意義の解明

科学研究費助成事業, 新学術領域研究(研究領域提案型), 日本学術振興会, 2009 - 2010

河原行郎
筋萎縮性側索硬化症におけるグルタミン酸受容体を介する神経細胞死のメカニズム

科学研究費助成事業, 特別研究員奨励費, 日本学術振興会, 2004 - 2004

河原行郎

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