2002年2月
An in vitro screening method for DNA cytosine-C-5-methylase inhibitor
NATURAL PRODUCT LETTERS
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- 巻
- 16
- 号
- 1
- 開始ページ
- 25
- 終了ページ
- 27
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1080/1057563029001/4809
- 出版者・発行元
- TAYLOR & FRANCIS LTD
A specific inhibitor of DNA cytosine C-5-methylases would be useful for studying genomic imprinting, X-chromosome inactivation, carcinogenesis, and regulation of tissue-specific gene expression, for these physiological phenomena appears to be regulated through DNA methylation in promoter sequences. This paper reports a novel convenient in vitro assay method for screening DNA cytosine C-5-Methylase inhibitor. Our method uses a commercially available Hae III methylase (cytosine C-5 methylase), its corresponding Hae III endonuclease, and lambda DNA as their substrate.
- リンク情報
- ID情報
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- DOI : 10.1080/1057563029001/4809
- ISSN : 1057-5634
- Web of Science ID : WOS:000174766700005