Chaleckis Romanas

What is health? Despite our best efforts, biomedical science has failed to provide a concrete definition. The World Health Organization defines health as “a state of complete physical, mental, and social well-being and not merely the absence of disease or infirmity”. However, traditional biomedicine focuses on identifying pathways and mechanisms associated with disease symptoms, not on understanding the processes that keep us healthy. It is not possible to understand deviations from health, whether disease-, environment-, or therapeutic-induced, without first establishing a baseline and definition of health. Disease can be defined as a shift from health in the sense that the system has been perturbed to the extent that the range of the dynamic equilibrium has been exceeded. Essentially, the natural buffering capacity of the healthy system has been saturated, and the organism responds with the manifestation of disease. Intervention then becomes a process of restoring the individual to equilibrium. This process can vary depending upon an individual’s personal biochemical profile, leading to the concept of “personalized medicine” to develop a specific response.
Metabolome analysis of biofluids (urine, blood) is a crucial tool to understand and follow individuals health state.