2013年10月
Guardians of the actin monomer
EUROPEAN JOURNAL OF CELL BIOLOGY
- ,
- 巻
- 92
- 号
- 10-11
- 開始ページ
- 316
- 終了ページ
- 332
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.ejcb.2013.10.012
- 出版者・発行元
- ELSEVIER GMBH, URBAN & FISCHER VERLAG
Actin is a universal force provider in eukaryotic cells. Biological processes harness the pressure generated from actin polymerization through dictating the time, place and direction of filament growth. As such, polymerization is initiated and maintained via tightly controlled filament nucleation and elongation machineries. Biological systems integrate force into their activities through recruiting and activating these machineries. In order that actin function as a common force generating polymerization motor, cells must maintain a pool of active, polymerization-ready monomeric actin, and minimize extemporaneous polymerization. Maintenance of the active monomeric actin pool requires the recycling of actin filaments, through depolymerization, nucleotide exchange and reloading of the polymerization machineries, while the levels of monomers are constantly monitored and supplemented, when needed, via the access of a reserve pool of monomers and through gene expression. Throughout its monomeric life, actin needs to be protected against gratuitous nucleation events. Here, we review the proteins that act as custodians of monomeric actin. We estimate their levels on a tissue scale, and calculate the implied concentrations of each actin complex based on reported binding affinities. These estimations predict that monomeric actin is rarely, if ever, alone. Thus, the guardians keep the volatility of actin in check, so that its explosive power is only released in the controlled environments of the nucleation and polymerization machineries. (C) 2013 Elsevier GmbH. All rights reserved.
- リンク情報
-
- DOI
- https://doi.org/10.1016/j.ejcb.2013.10.012
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/24268205
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000329260500002&DestApp=WOS_CPL
- URL
- http://orcid.org/0000-0001-6367-6903
- ID情報
-
- DOI : 10.1016/j.ejcb.2013.10.012
- ISSN : 0171-9335
- eISSN : 1618-1298
- ORCIDのPut Code : 18082970
- PubMed ID : 24268205
- Web of Science ID : WOS:000329260500002