2014年6月27日
Ataxia telangiectasia derived iPS cells show preserved x-ray sensitivity and decreased chromosomal instability
Scientific Reports
- 巻
- 4
- 号
- 1
- 記述言語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1038/srep05421
- 出版者・発行元
- Springer Science and Business Media LLC
Abstract
Ataxia telangiectasia is a neurodegenerative inherited disease with chromosomal instability and hypersensitivity to ionizing radiation. iPS cells lacking ATM (AT-iPS cells) exhibited hypersensitivity to X-ray irradiation, one of the characteristics of the disease. While parental ataxia telangiectasia cells exhibited significant chromosomal abnormalities, AT-iPS cells did not show any chromosomal instability in vitro for at least 80 passages (560 days). Whole exome analysis also showed a comparable nucleotide substitution rate in AT-iPS cells. Taken together, these data show that ATM is involved in protection from irradiation-induced cell death.
Ataxia telangiectasia is a neurodegenerative inherited disease with chromosomal instability and hypersensitivity to ionizing radiation. iPS cells lacking ATM (AT-iPS cells) exhibited hypersensitivity to X-ray irradiation, one of the characteristics of the disease. While parental ataxia telangiectasia cells exhibited significant chromosomal abnormalities, AT-iPS cells did not show any chromosomal instability in vitro for at least 80 passages (560 days). Whole exome analysis also showed a comparable nucleotide substitution rate in AT-iPS cells. Taken together, these data show that ATM is involved in protection from irradiation-induced cell death.
- リンク情報
-
- DOI
- https://doi.org/10.1038/srep05421
- J-GLOBAL
- https://jglobal.jst.go.jp/detail?JGLOBAL_ID=201702202298428705
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/24970375
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000338102300001&DestApp=WOS_CPL
- URL
- https://www.nature.com/articles/srep05421.pdf
- URL
- https://www.nature.com/articles/srep05421
- ID情報
-
- DOI : 10.1038/srep05421
- ISSN : 2045-2322
- eISSN : 2045-2322
- J-Global ID : 201702202298428705
- PubMed ID : 24970375
- Web of Science ID : WOS:000338102300001