論文

査読有り
2014年

SOCS1 and Regulation of Regulatory T Cells Plasticity

JOURNAL OF IMMUNOLOGY RESEARCH
  • Reiko Takahashi
  • ,
  • Akihiko Yoshimura

2014
開始ページ
943149
終了ページ
記述言語
英語
掲載種別
DOI
10.1155/2014/943149
出版者・発行元
HINDAWI PUBLISHING CORPORATION

Several reports have suggested that natural regulatory T cells (Tregs) lose Forkhead box P3 (Foxp3) expression and suppression activity under certain inflammatory conditions. Treg plasticity has been studied because it may be associated with the pathogenesis of autoimmunity. Some studies showed that a minor uncommitted Foxp3(+) T cell population, which lacks hypomethylation at Treg-specific demethylation regions (TSDRs), may convert to effector/helper T cells. Suppressor of cytokine signaling 1 (SOCS1), a negative regulator of cytokine signaling, has been reported to play an important role in Treg cell integrity and function by protecting the cells from excessive inflammatory cytokines. In this review, we discuss Treg plasticity and maintenance of suppression functions in both physiological and pathological settings. In addition, we discuss molecular mechanisms of maintaining Treg plasticity by SOCS1 and other molecules. Such information will be useful for therapy of autoimmune diseases and reinforcement of antitumor immunity.

Web of Science ® 被引用回数 : 17

リンク情報
DOI
https://doi.org/10.1155/2014/943149
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/25133199
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000339759900001&DestApp=WOS_CPL

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