論文

査読有り
2011年5月

Suppressors of Cytokine Signaling (SOCS) Proteins and JAK/STAT Pathways Regulation of T-Cell Inflammation by SOCS1 and SOCS3

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
  • Taiga Tamiya
  • ,
  • Ikko Kashiwagi
  • ,
  • Reiko Takahashi
  • ,
  • Hideo Yasukawa
  • ,
  • Akihiko Yoshimura

31
5
開始ページ
980
終了ページ
985
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1161/ATVBAHA.110.207464
出版者・発行元
LIPPINCOTT WILLIAMS & WILKINS

Various cytokines are involved in the regulation of the immune system and inflammation. Dysregulation of cytokine signaling can cause a variety of diseases, including allergy, autoimmune diseases, inflammation, and cancer. Most cytokines use the so-called janus kinase/signal transducer and activator of transcription pathway, and this pathway is negatively regulated by suppressors of cytokine signaling (SOCS) proteins. SOCS proteins bind to janus kinase and to certain cytokine receptors and signaling molecules, thereby suppressing further signaling events. Studies have shown that SOCS proteins are key physiological regulators of inflammation. Recent studies have also demonstrated that SOCS1 and SOCS3 are important regulators of adaptive immunity. (Arterioscler Thromb Vasc Biol. 2011;31:980-985.)

Web of Science ® 被引用回数 : 202

リンク情報
DOI
https://doi.org/10.1161/ATVBAHA.110.207464
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/21508344
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000289720800009&DestApp=WOS_CPL

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