Ito Ryo

Profile Information

Affiliation: Tohoku University

Degree: PhD(Mar, 2014, The University of Tokyo)

J-GLOBAL ID: 201801010571600238
researchmap Member ID: B000301135

Research Areas

Life sciences / Metabolism and endocrinology /

Papers

Environmental factor reversibly determines cellular identity through opposing Integrators that unify epigenetic and transcriptional pathways.

Hiroki Takahashi, Ryo Ito, Yoshihiro Matsumura, Juro Sakai

BioEssays : news and reviews in molecular, cellular and developmental biology, 46(2) e2300084, Feb, 2024
Chemogenetic activation of G12 signaling enhances adipose tissue browning.

Yuki Ono, Ryo Ito, Kaito Arai, Gurdeep Singh, Tsuyoshi Saitoh, Robert B Russell, Francesco Raimondi, Junken Aoki, Juro Sakai, Asuka Inoue

Signal transduction and targeted therapy, 8(1) 307-307, Aug 21, 2023
MYPT1-PP1β phosphatase negatively regulates both chromatin landscape and co-activator recruitment for beige adipogenesis.

Hiroki Takahashi, Ge Yang, Takeshi Yoneshiro, Yohei Abe, Ryo Ito, Chaoran Yang, Junna Nakazono, Mayumi Okamoto-Katsuyama, Aoi Uchida, Makoto Arai …

Nature communications, 13(1) 5715-5715, Sep 29, 2022
Spatiotemporal dynamics of SETD5-containing NCoR-HDAC3 complex determines enhancer activation for adipogenesis.

Yoshihiro Matsumura, Ryo Ito, Ayumu Yajima, Rei Yamaguchi, Toshiya Tanaka, Takeshi Kawamura, Kenta Magoori, Yohei Abe, Aoi Uchida, Takeshi Yoneshiro …

Nature communications, 12(1) 7045-7045, Dec 2, 2021
Discovery of a chemical compound that suppresses expression of BEX2, a dormant cancer stem cell-related protein

Satoshi Saijoh, Mao Nakamura-Shima, Rie Shibuya-Takahashi, Ryo Ito, Akira Sugawara, Tomoko Yamazaki, Takayuki Imai, Yukinori Asada, Kazuto Matsuura, Wataru Iwai …

Biochemical and Biophysical Research Communications, 537 132-139, Jan, 2021 Peer-reviewed
The establishment of a novel high-throughput screening system using RNA-guided genome editing to identify chemicals that suppress aldosterone synthase expression.

Ryo Ito, Masanobu Morita, Taichi Nakano, Ikuko Sato, Atsushi Yokoyama, Akira Sugawara

Biochemical and biophysical research communications, 534 672-679, Jan 1, 2021
Comparative proteomic analysis to identify the novel target gene of angiotensin II in adrenocortical H295R cells.

Ryo Ito, Hiroki Shima, Koji Masuda, Ikuko Sato, Hiroki Shimada, Atsushi Yokoyama, Katsuhiko Shirahige, Kazuhiko Igarashi, Akira Sugawara

Endocrine journal, 68(4) 441-450, Dec 26, 2020
FABP7 Regulates Acetyl-CoA Metabolism Through the Interaction with ACLY in the Nucleus of Astrocytes

Yoshiteru Kagawa, Banlanjo Abdulaziz Umaru, Hiroki Shima, Ryo Ito, Ryo Zama, Ariful Islam, Shin-ichiro Kanno, Akira Yasui, Shun Sato, Kosuke Jozaki …

Molecular Neurobiology, 57(12) 4891-4910, Dec, 2020 Peer-reviewed
CYP11B2を標的とした原発性アルドステロン症の新規創薬の試み

星啓太, 伊藤亮, 佐藤郁子, 坂本純, 島田洋樹, 横山敦, 菅原明

日本内分泌学会雑誌, 95(1) 501-501, Apr, 2019
Suppressive effects of RXR agonist PA024 on adrenal CYP11B2 expression, aldosterone secretion and blood pressure

Dai Suzuki, Akiko Saito-Hakoda, Ryo Ito, Kyoko Shimizu, Rehana Parvin, Hiroki Shimada, Erika Noro, Susumu Suzuki, Ikuma Fujiwara, Hiroyuki Kagechika …

PLOS ONE, 12(8), Aug, 2017 Peer-reviewed
A ubiquitin-proteasome inhibitor bortezomib suppresses the expression of CYP11B2, a key enzyme of aldosterone synthesis

Ryo Ito, Ikuko Sato, Tadayuki Tsujita, Atsushi Yokoyama, Akira Sugawara

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 489(1) 21-28, Jul, 2017 Peer-reviewed
脂肪細胞由来の未知のアルドステロン合成酵素(CYP11B2)発現誘導因子の探索

島田洋樹, 伊藤亮, 佐藤恵美子, 横山敦, 菅原明

日本内分泌学会雑誌, 92(1) 216-216, Apr, 2016
Hydroxylation of methylated DNA by TET1 in chondrocyte differentiation of C3H10T1/2 cells

Ryo Ito, Hiroki Shimada, Kengo Yazawa, Ikuko Sato, Yuuki Imai, Akira Sugawara, Atsushi Yokoyama

Biochemistry and Biophysics Reports, 5 134-140, Mar 1, 2016 Peer-reviewed
高血糖刺激による副腎アルドステロン合成酵素遺伝子(CYP11B2)発現亢進

小暮直敬, 菅原香織, 工藤正孝, 島田洋樹, 箱田明子, 伊藤亮, 横山敦, 菅原明

糖尿病, 58(Suppl.1) S-356, Apr, 2015
高血糖刺激による副腎アルドステロン合成酵素遺伝子(CYP11B2)発現亢進の分子機構

小暮直敬, 菅原香織, 松田謙, 宇留野晃, 佐藤郁子, 清水恭子, レハナ・パービン, 島田洋樹, 吉川雄朗, 工藤正孝 …

日本高血圧学会総会プログラム・抄録集, 37回 333-333, Oct, 2014
アルドステロン合成酵素遺伝子(CYP11B2)をターゲットとした新規創薬

伊藤亮, 島田洋樹, 松田謙, 宇留野晃, 横山敦, 菅原明

日本高血圧学会総会プログラム・抄録集, 37回 393-393, Oct, 2014
高血糖刺激は副腎11β-水酸化酵素遺伝子(CYP11B1)の発現を誘導する

菅原香織, 小暮直敬, 松田謙, 宇留野晃, 佐藤郁子, 清水恭子, レハナ・パービン, 島田洋樹, 吉川雄朗, 工藤正孝 …

日本高血圧学会総会プログラム・抄録集, 37回 399-399, Oct, 2014
High-Glucose Stimulates Aldosterone Synthase Gene (CYP11B2) Expression Via the Induction of T-Type Calcium Channels in H295R Cells

Naotaka Kogure, Ken Matsuda, Akira Uruno, Kaori Sugawara, Ikuko Sato, Kyoko Shimizu, Rehana Parvin, Takeo Yoshikawa, Masataka Kudo, Akiko Saito-Hakoda …

ENDOCRINE REVIEWS, 35(3), Jun, 2014 Peer-reviewed
Identification of Myelin Transcription Factor 1 (MyT1) as a Subunit of the Neural Cell Type-specific Lysine-specific Demethylase 1 (LSD1) Complex

Atsushi Yokoyama, Katsuhide Igarashi, Tetsuya Sato, Kiyoshi Takagi, Maky Otsuka, Yurina Shishido, Takashi Baba, Ryo Ito, Jun Kanno, Yasuyuki Ohkawa …

JOURNAL OF BIOLOGICAL CHEMISTRY, 289(26) 18152-18162, Jun, 2014 Peer-reviewed
Generation of a Stable H295R Cell Line Expressing 11beta-Hydroxylase Gene Promoter and the Effect of High-Glucose on Its Expression

Kaori Sugawara, Ken Matsuda, Naotaka Kogure, Akira Uruno, Ikuko Sato, Kyoko Shimizu, Rehana Parvin, Takeo Yoshikawa, Masataka Kudo, Akiko Saito-Hakoda …

ENDOCRINE REVIEWS, 35(3), Jun, 2014 Peer-reviewed

Misc.

未知の脂肪細胞由来アルドステロン合成酵素(CYP11B2)発現誘導因子の探索

島田洋樹, 伊藤亮, 佐藤恵美子, 伊藤貞嘉, 横山敦, 菅原明

日本高血圧学会総会プログラム・抄録集, 39th 331-331, Sep 30, 2016
軟骨細胞の分化におけるIGF‐1遺伝子のエピジェネティック制御と成長ホルモンの作用

菅原明, 横山敦, 伊藤亮

成長科学協会研究年報, (39) 115, Sep 1, 2016
レチノイドX受容体(RXR)アゴニストPA024が副腎CYP11B2発現、アルドステロン分泌および血圧に及ぼす影響

鈴木大, 箱田明子, 伊藤亮, 清水恭子, 小暮直敬, 青木聡, 影近弘之, 呉繁夫, 伊藤貞嘉, 横山敦 …

日本高血圧学会総会プログラム・抄録集, 39回 336-336, Sep, 2016
軟骨細胞の分化におけるIGF‐1遺伝子のエピジェネティック制御と成長ホルモンの作用

菅原明, 横山敦, 伊藤亮

東北医学雑誌, 128(1) 72, Jun 25, 2016

Research Projects

Understanding of sarcopenia obesity by epigenomic regulation

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2021 - Mar, 2024
Regulatory mechanism of beige adipocyte-differentiation by protein phosphatase.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Early-Career Scientists, Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2021

Ito Ryo
Understanding of molecular mechanism for overgrowth of the cells in adrenal zona glomerulosa

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2018

ITO Ryo
Innovation of novel therapeutics against diabetic nephropathy targeting ChREBP

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2018

Sugawara Akira, SAWATUBASHI Shun, TAKEMOTO Tatsuya, YAMAMOTO Yasuhiko, TAKAGI Kiyoshi, Sato Horoshi, Yokoyama Atsushi, ITO Ryo, DOI Takayuki
Establishment of the isolation-method of adrenal zona gromerulosa and the analysis of CYP11B2 gene regulation.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Research Activity Start-up, Japan Society for the Promotion of Science, Aug, 2014 - Mar, 2016

Ito Ryo

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