論文

査読有り
2020年12月

FABP7 Regulates Acetyl-CoA Metabolism Through the Interaction with ACLY in the Nucleus of Astrocytes

Molecular Neurobiology
  • Yoshiteru Kagawa
  • ,
  • Banlanjo Abdulaziz Umaru
  • ,
  • Hiroki Shima
  • ,
  • Ryo Ito
  • ,
  • Ryo Zama
  • ,
  • Ariful Islam
  • ,
  • Shin-ichiro Kanno
  • ,
  • Akira Yasui
  • ,
  • Shun Sato
  • ,
  • Kosuke Jozaki
  • ,
  • Subrata Kumar Shil
  • ,
  • Hirofumi Miyazaki
  • ,
  • Shuhei Kobayashi
  • ,
  • Yui Yamamoto
  • ,
  • Hiroshi Kogo
  • ,
  • Chie Shimamoto-Mitsuyama
  • ,
  • Akira Sugawara
  • ,
  • Norihiro Sugino
  • ,
  • Masayuki Kanamori
  • ,
  • Teiji Tominaga
  • ,
  • Takeo Yoshikawa
  • ,
  • Kohji Fukunaga
  • ,
  • Kazuhiko Igarashi
  • ,
  • Yuji Owada

57
12
開始ページ
4891
終了ページ
4910
記述言語
掲載種別
研究論文(学術雑誌)
DOI
10.1007/s12035-020-02057-3
出版者・発行元
Springer Science and Business Media LLC

<title>Abstract</title>
Fatty acid binding protein 7 (FABP7) is an intracellular fatty acid chaperon that is highly expressed in astrocytes, oligodendrocyte-precursor cells, and malignant glioma. Previously, we reported that FABP7 regulates the response to extracellular stimuli by controlling the expression of caveolin-1, an important component of lipid raft. Here, we explored the detailed mechanisms underlying FABP7 regulation of caveolin-1 expression using primary cultured FABP7-KO astrocytes as a model of loss of function and NIH-3T3 cells as a model of gain of function. We discovered that FABP7 interacts with ATP-citrate lyase (ACLY) and is important for acetyl-CoA metabolism in the nucleus. This interaction leads to epigenetic regulation of several genes, including caveolin-1. Our novel findings suggest that FABP7-ACLY modulation of nuclear acetyl-CoA has more influence on histone acetylation than cytoplasmic acetyl-CoA. The changes to histone structure may modify caveolae-related cell activity in astrocytes and tumors, including malignant glioma.

リンク情報
DOI
https://doi.org/10.1007/s12035-020-02057-3
URL
http://link.springer.com/content/pdf/10.1007/s12035-020-02057-3.pdf
URL
http://link.springer.com/article/10.1007/s12035-020-02057-3/fulltext.html

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