論文

査読有り 国際誌
2020年6月12日

The clinicopathological and molecular features of sporadic gastric foveolar type neoplasia.

Virchows Archiv : an international journal of pathology
  • Tamotsu Sugai
  • ,
  • Noriyuki Uesugi
  • ,
  • Wataru Habano
  • ,
  • Ryo Sugimoto
  • ,
  • Makoto Eizuka
  • ,
  • Yasuko Fujita
  • ,
  • Mitsumasa Osakabe
  • ,
  • Yosuke Toya
  • ,
  • Hiromu Suzuki
  • ,
  • Takayuki Matsumoto

477
6
開始ページ
835
終了ページ
844
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1007/s00428-020-02846-0

Gastric intraepithelial foveolar type neoplasia (IEFN) is not well defined. In addition, atrophic mucosa (AM) is an important issue to consider when evaluating gastric tumorigenesis. Here, we assessed the clinicopathological characteristics and molecular alterations contributing to the development of IEFN compared with intestinal type neoplasia. We examined the clinicopathological and molecular features of 42 cases of IEFN with low-grade dysplasia (LGD) and those of 77 cases of intraepithelial intestinal type neoplasia (IEIN) with LGD. The clinicopathological and molecular features examined included the AM status, mucin phenotype expression, CDX2 expression, p53 overexpression, β-catenin intranuclear accumulation, microsatellite instability (MSI), DNA methylation status (low methylation epigenotype [LME], intermediate ME, or high ME), allelic imbalances (AIs), and APC promoter 1B mutations. There were no differences in the frequencies of AM and rates of CDX2 expression between IEFN and IEIN cases. Although no differences in the frequencies of p53 overexpression and MSI were observed between the two histological types, intranuclear expression of β-catenin was significantly higher in IEIN than in IEFN. In addition, although the rate of LME was significantly higher in IEFN cases than in IEIN cases, IEFN was characterized by AIs at multiple foci. Finally, mutation of the APC promoter 1B, which is a characteristic of gastric adenocarcinoma and proximal polyposis of the stomach (potentially resembling IEFN), was detected in only one IEFN case. These findings suggested that IEFN may be an independent entity in terms of molecular alterations including the presence of multiple AIs and LME.

リンク情報
DOI
https://doi.org/10.1007/s00428-020-02846-0
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32533343
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7683467
ID情報
  • DOI : 10.1007/s00428-020-02846-0
  • PubMed ID : 32533343
  • PubMed Central 記事ID : PMC7683467

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