2011年6月
Role of Megalin and Cubilin in the Metabolism of Vitamin D-3
THERAPEUTIC APHERESIS AND DIALYSIS
- ,
- ,
- ,
- 巻
- 15
- 号
- 開始ページ
- 14
- 終了ページ
- 17
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1111/j.1744-9987.2011.00920.x
- 出版者・発行元
- WILEY-BLACKWELL
Vitamin D deficiency is associated with various medical conditions including musculoskeletal disorders, infection, metabolic diseases, and cardiovascular disease. Megalin and cubilin, endocytic receptors in proximal tubule cells, are involved in the reabsorption of vitamin D binding protein from glomerular filtrates and the subsequent intracellular conversion of 25-hydroxyvitamin D-3 to biologically active 1 alpha,25-dihydroxyvitamin D-3. Dysfunction of these receptors, which is commonly found in patients with diabetic nephropathy, even at early stages, may explain why vitamin D deficiency is often complicated in these patients. Therapeutic strategies to protect the functions of these receptors from injury could be used to prevent vitamin D deficiency and its related disorders.
- リンク情報
- ID情報
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- DOI : 10.1111/j.1744-9987.2011.00920.x
- ISSN : 1744-9979
- PubMed ID : 21595846
- Web of Science ID : WOS:000292544600004