2011年5月
Catalytic Asymmetric Hydrogenation of N-Boc-Imidazoles and Oxazoles
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- ,
- ,
- 巻
- 133
- 号
- 19
- 開始ページ
- 7312
- 終了ページ
- 7315
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1021/ja201543h
- 出版者・発行元
- AMER CHEMICAL SOC
Substituted imidazoles and oxazoles were respectively hydrogenated into the corresponding chiral imidazolines and oxazolines (up to 99% ee). The highly enantioselective hydrogenation was achieved by using the chiral ruthenium catalyst, which is generated from Ru(eta(3)-methallyl)(2)(cod) and a trans-chelating chiral bisphosphine ligand, PhTRAP. This is the first successful catalytic asymmetric reduction of 5-membered aromatic rings containing two or more heteroatoms.
- リンク情報
- ID情報
-
- DOI : 10.1021/ja201543h
- ISSN : 0002-7863
- Web of Science ID : WOS:000290782200020