論文

査読有り
2017年3月

Essential roles of Tbx3 in embryonic skin development during epidermal stratification

GENES TO CELLS
  • Ryo Ichijo
  • ,
  • Yui Iizuka
  • ,
  • Hirokazu Kubo
  • ,
  • Fumiko Toyoshima

22
3
開始ページ
284
終了ページ
292
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1111/gtc.12476
出版者・発行元
WILEY

Stepwise differentiation of epidermal cells is essential for development of stratified epithelium, but the underlying mechanisms remain unclear. Here, we show that Tbx3, a member of the T-box family of transcription factors, plays a pivotal role in this mechanism. Tbx3 is expressed in both basal and suprabasal cells in the interfollicular epidermis of mouse embryos. Epidermis-specific Tbx3 conditional knockout (cKO) embryos are small in size and display a thinner epidermis with an impaired barrier function. In the Tbx3 cKO epidermis, keratin 5-positive undifferentiated cells, which reside in both basal and suprabasal layers of wild-type embryos, are localized exclusively in the basal layer. In addition, mRNA expression levels of granular cell markers are increased in the Tbx3 cKO epidermis, suggesting that Tbx3 prevents premature differentiation of spinous cells. We further show that Tbx3 maintains the proliferative potential of basal cells and ensures their planar-oriented cell division. Moreover, Tbx3 is shown to be required for the expression of Hes1, a well-known Notch signaling target protein that is essential for epidermal development. We therefore propose that Tbx3 functions upstream of Hes1 to regulate proliferation and differentiation of basal and suprabasal cells during epidermal development.

Web of Science ® 被引用回数 : 3

リンク情報
DOI
https://doi.org/10.1111/gtc.12476
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/28205312
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000397501300004&DestApp=WOS_CPL

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