論文

査読有り
2017年9月

Tbx3-dependent amplifying stem cell progeny drives interfollicular epidermal expansion during pregnancy and regeneration

NATURE COMMUNICATIONS
  • Ryo Ichijo
  • ,
  • Hiroki Kobayashi
  • ,
  • Saori Yoneda
  • ,
  • Yui Iizuka
  • ,
  • Hirokazu Kubo
  • ,
  • Shigeru Matsumura
  • ,
  • Satsuki Kitano
  • ,
  • Hitoshi Miyachi
  • ,
  • Tetsuya Honda
  • ,
  • Fumiko Toyoshima

8
1
開始ページ
508
終了ページ
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1038/s41467-017-00433-7
出版者・発行元
NATURE PUBLISHING GROUP

The skin surface area varies flexibly in response to body shape changes. Skin homeostasis is maintained by stem cells residing in the basal layer of the interfollicular epidermis. However, how the interfollicular epidermal stem cells response to physiological body shape changes remains elusive. Here, we identify a highly proliferative interfollicular epidermal basal cell population in the rapidly expanding abdominal skin of pregnant mice. These cells express Tbx3 that is necessary for their propagation to drive skin expansion. The Tbx(3+) basal cells are generated from Axin(2+) interfollicular epidermal stem cells through planar-oriented asymmetric or symmetric cell divisions, and express transit-amplifying cell marker CD71. This biased division of Axin(2+) interfollicular epidermal stem cells is induced by Sfrp1 and Igfbp2 proteins secreted from dermal cells. The Tbx(3+) basal cells promote wound repair, which is enhanced by Sfrp1 and Igfbp2. This study elucidates the interfollicular epidermal stem cell/progeny organisation during pregnancy and suggests its application in regenerative medicine.

Web of Science ® 被引用回数 : 9

リンク情報
DOI
https://doi.org/10.1038/s41467-017-00433-7
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/28894084
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000410237600010&DestApp=WOS_CPL

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