論文

査読有り 本文へのリンクあり
2018年12月1日

Transient elevation of cytoplasmic calcium ion concentration at a single cell level precedes morphological changes of epidermal keratinocytes during cornification

Scientific Reports
  • Teruasa Murata
  • ,
  • Tetsuya Honda
  • ,
  • Gyohei Egawa
  • ,
  • Yasuo Yamamoto
  • ,
  • Ryo Ichijo
  • ,
  • Fumiko Toyoshima
  • ,
  • Teruki Dainichi
  • ,
  • Kenji Kabashima

8
1
開始ページ
6610
終了ページ
記述言語
掲載種別
研究論文(学術雑誌)
DOI
10.1038/s41598-018-24899-7

© 2018 The Author(s). Epidermal keratinocytes achieve sequential differentiation from basal to granular layers, and undergo a specific programmed cell death, cornification, to form an indispensable barrier of the body. Although elevation of the cytoplasmic calcium ion concentration ([Ca2+]i) is one of the factors predicted to regulate cornification, the dynamics of [Ca2+]i in epidermal keratinocytes is largely unknown. Here using intravital imaging, we captured the dynamics of [Ca2+]i in mouse skin. [Ca2+]i was elevated in basal cells on the second time scale in three spatiotemporally distinct patterns. The transient elevation of [Ca2+]i also occurred at the most apical granular layer at a single cell level, and lasted for approximately 40 min. The transient elevation of [Ca2+]i at the granular layer was followed by cornification, which was completed within 10 min. This study demonstrates the tightly regulated elevation of [Ca2+]i preceding the cornification of epidermal keratinocytes, providing possible clues to the mechanisms of cornification.

リンク情報
DOI
https://doi.org/10.1038/s41598-018-24899-7
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/29700333
Scopus
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85045989649&origin=inward 本文へのリンクあり
Scopus Citedby
https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85045989649&origin=inward

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