2009年8月
A trophic role for Wnt-Ror kinase signaling during developmental pruning in Caenorhabditis elegans
NATURE NEUROSCIENCE
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- 巻
- 12
- 号
- 8
- 開始ページ
- 981
- 終了ページ
- U43
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1038/nn.2347
- 出版者・発行元
- NATURE PUBLISHING GROUP
The molecular mechanism by which neurites are selected for elimination or incorporation into the mature circuit during developmental pruning remains unknown. The trophic theory postulates that local cues provided by target or surrounding cells act to inhibit neurite elimination. However, no widely conserved factor mediating this trophic function has been identified. We found that the developmental survival of specific neurites in Caenorhabditis elegans largely depends on detection of the morphogen Wnt by the Ror kinase CAM-1, which is a transmembrane tyrosine kinase with a Frizzled domain. Mutations in Wnt genes or in cam-1 enhanced neurite elimination, whereas overexpression of cam-1 inhibited neurite elimination in a Wnt-dependent manner. Moreover, mutations in these genes counteracted the effect of a mutation in mbr-1, which encodes a transcription factor that promotes neurite elimination. These results reveal the trophic role of an atypical Wnt pathway and reinforce the classical model of developmental pruning.
- リンク情報
- ID情報
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- DOI : 10.1038/nn.2347
- ISSN : 1097-6256
- PubMed ID : 19561603
- Web of Science ID : WOS:000268396300011