2015年9月
Lack of C9orf72 Expansion in 406 Sporadic and Familial Cases of Idiopathic Dystonia in Japan
MOVEMENT DISORDERS
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- 巻
- 30
- 号
- 10
- 開始ページ
- 1430
- 終了ページ
- 1431
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1002/mds.26310
- 出版者・発行元
- WILEY-BLACKWELL
BackgroundIt has been suggested that treatment with ethyl-eicosapentaenoic acid (EPA) may improve motor function in patients with Huntington's disease (HD) with cytosine-adenine-guanine repeat numbers of <45.
MethodsThis multicenter, randomized, double-blind, placebo-controlled 6-month trial compared the effects of ethyl-EPA versus placebo on 290 subjects with mild-to-moderate HD. The primary endpoint was the change from baseline to 6 months in the Total Motor Score 4 (TMS-4) component of the Unified Huntington's Disease Rating Scale (UHDRS). Secondary endpoints included change from baseline in UHDRS subscores and Clinical Global Impression (CGI).
ResultsNo significant differences in TMS-4 scores were noted between treatment groups. Similarly, there were no significant differences between groups on any of the UHDRS subscores or CGI scores.
ConclusionEthyl-EPA was not beneficial in patients with HD during 6 months of placebo-controlled evaluation. (c) 2015 International Parkinson and Movement Disorder Society
MethodsThis multicenter, randomized, double-blind, placebo-controlled 6-month trial compared the effects of ethyl-EPA versus placebo on 290 subjects with mild-to-moderate HD. The primary endpoint was the change from baseline to 6 months in the Total Motor Score 4 (TMS-4) component of the Unified Huntington's Disease Rating Scale (UHDRS). Secondary endpoints included change from baseline in UHDRS subscores and Clinical Global Impression (CGI).
ResultsNo significant differences in TMS-4 scores were noted between treatment groups. Similarly, there were no significant differences between groups on any of the UHDRS subscores or CGI scores.
ConclusionEthyl-EPA was not beneficial in patients with HD during 6 months of placebo-controlled evaluation. (c) 2015 International Parkinson and Movement Disorder Society
- リンク情報
- ID情報
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- DOI : 10.1002/mds.26310
- ISSN : 0885-3185
- eISSN : 1531-8257
- PubMed ID : 26173439
- Web of Science ID : WOS:000360759500052