2016年7月11日
Modeling Alexander disease with patient iPSCs reveals cellular and molecular pathology of astrocytes.
Acta neuropathologica communications
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- 巻
- 4
- 号
- 1
- 開始ページ
- 69
- 終了ページ
- 69
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1186/s40478-016-0337-0
- 出版者・発行元
- BIOMED CENTRAL LTD
Alexander disease is a fatal neurological illness characterized by white-matter degeneration and formation of Rosenthal fibers, which contain glial fibrillary acidic protein as astrocytic inclusion. Alexander disease is mainly caused by a gene mutation encoding glial fibrillary acidic protein, although the underlying pathomechanism remains unclear. We established induced pluripotent stem cells from Alexander disease patients, and differentiated induced pluripotent stem cells into astrocytes. Alexander disease patient astrocytes exhibited Rosenthal fiber-like structures, a key Alexander disease pathology, and increased inflammatory cytokine release compared to healthy control. These results suggested that Alexander disease astrocytes contribute to leukodystrophy and a variety of symptoms as an inflammatory source in the Alexander disease patient brain. Astrocytes, differentiated from induced pluripotent stem cells of Alexander disease, could be a cellular model for future translational medicine.
- リンク情報
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- DOI
- https://doi.org/10.1186/s40478-016-0337-0
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/27402089
- PubMed Central
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4940830
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000379524200002&DestApp=WOS_CPL
- ID情報
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- DOI : 10.1186/s40478-016-0337-0
- ISSN : 2051-5960
- PubMed ID : 27402089
- PubMed Central 記事ID : PMC4940830
- Web of Science ID : WOS:000379524200002