論文

査読有り 国際誌
2012年5月

Selective white matter abnormalities in a novel rat model of vascular dementia.

Neurobiology of aging
  • Akihiro Kitamura
  • Youshi Fujita
  • Naoya Oishi
  • Raj N Kalaria
  • Kazuo Washida
  • Takakuni Maki
  • Yoko Okamoto
  • Yoshiki Hase
  • Mahito Yamada
  • Jun Takahashi
  • Hidefumi Ito
  • Hidekazu Tomimoto
  • Hidenao Fukuyama
  • Ryosuke Takahashi
  • Masafumi Ihara
  • 全て表示

33
5
開始ページ
1012.e25-35
終了ページ
35
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.neurobiolaging.2011.10.033
出版者・発行元
ELSEVIER SCIENCE INC

Rats subjected to bilateral common carotid artery (CCA) occlusion or 2-vessel occlusion (2VO) have been used as animal models of subcortical ischemic vascular dementia. However, this model possesses an inherent limitation in that cerebral blood flow (CBF) drops too sharply and substantially after ligation of CCAs. To circumvent such hypoxic-ischemic conditions, we tested implantation of the ameroid constrictor device on bilateral CCAs of male Wistar-Kyoto rats and more precisely replicated chronic cerebral hypoperfusion by gradual narrowing of the CCAs (2-vessel gradual occlusion; 2VGO). The acute cerebral blood flow reduction and resultant inflammatory responses observed in the 2VO rats were eliminated in the 2VGO rats. Thus, chronic cerebral hypoperfusion was segregated, and induced selective white matter changes with relatively preserved neurovascular coupling and substantially less metabolic and histological derangements in the gray matter including the hippocampus. This led to significant spatial working memory impairment of a magnitude similar to the 2VO rats at 28 days postoperation. The 2VGO model may more closely mimic cognitive impairment subsequent to selective white matter damage.

リンク情報
DOI
https://doi.org/10.1016/j.neurobiolaging.2011.10.033
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/22133276
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000302486200044&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/j.neurobiolaging.2011.10.033
  • ISSN : 0197-4580
  • PubMed ID : 22133276
  • Web of Science ID : WOS:000302486200044

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