論文

国際誌
2021年9月24日

Mitochondrial dysfunction in a mouse model of prodromal Parkinson's disease: A metabolomic analysis.

Neuroscience letters
  • Masashi Ikuno
  • ,
  • Hodaka Yamakado
  • ,
  • Ikuko Amano
  • ,
  • Yusuke Hatanaka
  • ,
  • Norihito Uemura
  • ,
  • Shu-Ichi Matsuzawa
  • ,
  • Ryosuke Takahashi

765
開始ページ
136267
終了ページ
136267
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.neulet.2021.136267

For the development of disease-modifying therapies for Parkinson's disease (PD) the identification of biomarkers in the prodromal stage is urgently required. Because PD is considered a systemic disease even in the early stage, we performed a metabolomic analysis of the plasma from a mouse model of prodromal PD (p-PD). Increased levels of isobutyrylcarnitine in p-PD mice imply an abnormality in β-oxidation in mitochondria, and increased levels of pyrimidine nucleoside can be associated with mitochondrial dysfunction. Consistent with these results, the immunoblot analysis showed a defect in mitochondrial complex I assembly in p-PD mice. These results suggest that systemic mitochondrial dysfunction may exist in p-PD mice and contribute to the pathogenesis of PD, potentially being useful as early biomarkers for PD.

リンク情報
DOI
https://doi.org/10.1016/j.neulet.2021.136267
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/34571089
ID情報
  • DOI : 10.1016/j.neulet.2021.136267
  • PubMed ID : 34571089

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