2021年9月24日
Mitochondrial dysfunction in a mouse model of prodromal Parkinson's disease: A metabolomic analysis.
Neuroscience letters
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- 巻
- 765
- 号
- 開始ページ
- 136267
- 終了ページ
- 136267
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.neulet.2021.136267
For the development of disease-modifying therapies for Parkinson's disease (PD) the identification of biomarkers in the prodromal stage is urgently required. Because PD is considered a systemic disease even in the early stage, we performed a metabolomic analysis of the plasma from a mouse model of prodromal PD (p-PD). Increased levels of isobutyrylcarnitine in p-PD mice imply an abnormality in β-oxidation in mitochondria, and increased levels of pyrimidine nucleoside can be associated with mitochondrial dysfunction. Consistent with these results, the immunoblot analysis showed a defect in mitochondrial complex I assembly in p-PD mice. These results suggest that systemic mitochondrial dysfunction may exist in p-PD mice and contribute to the pathogenesis of PD, potentially being useful as early biomarkers for PD.
- リンク情報
- ID情報
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- DOI : 10.1016/j.neulet.2021.136267
- PubMed ID : 34571089