Ryota Teramoto

Profile Information

Affiliation: Special Postdoctoral Researcher, Laboratory for Comprehensive Genomic Analysis, RIKEN Center for Integrative Medical Sciences
: Lecturer, Intractable Disease Research Center, Juntendo University Graduate School of Medicine

Degree: 博士（医学）(金沢大学大学院)
医師(自治医科大学医学部)

J-GLOBAL ID: 201901015483864020
researchmap Member ID: B000349165

External link: https://scholar.google.com/citations?view_op=list_works&hl=en&user=TuY3hDsAAAAJ

自治医科大学出身。地域医療に従事後、遺伝性心筋症の研究を始める。心筋肥大・線維化プロセスの解明を目指す。

Research Interests

Research Areas

Research History

Aug, 2021 - Present

非常勤講師, 難病の診断と治療研究センター, 順天堂大学大学院医学研究科
Aug, 2021 - Present

Special Postdoctoral Researcher, Laboratory for Comprehensive Genomic Analysis, RIKEN Center for Integrative Medical Sciences
Aug, 2017 - Jul, 2021

Research Fellow, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School
Apr, 2014 - Jul, 2017

Section of Emergency Medicine, Hospital, Kanazawa University
Apr, 2012 - Mar, 2014

医長, 内科, 珠洲市総合病院
Apr, 2010 - Mar, 2012

医員, 循環器内科, 石川県立中央病院
Apr, 2009 - Mar, 2010

医員, 内科, 公立宇出津総合病院
Apr, 2008 - Mar, 2009

所長, 白峰診療所
Oct, 2007 - Mar, 2008

医員, 内科, 市立輪島病院
Apr, 2007 - Sep, 2007

所長, 舳倉診療所
Apr, 2005 - Mar, 2007

初期研修医, 石川県立中央病院

Education

Oct, 2014 - Jun, 2018

Kanazawa University
Apr, 1999 - Mar, 2005

Jichi Medical University

Awards

2016

2016 Excellent Paper Award, Journal of Cardiology, Whole Exome Sequencing Combined with Integrated Variant Annotation Prediction Identifies a Causative Myosin Essential Light Chain Variant in Hypertrophic Cardiomyopathy

Research Projects

拡張型心筋症における心筋線維化分子基盤の解明

科学研究費助成事業若手研究, 若手研究, 日本学術振興会, Apr, 2023 - Mar, 2025

寺本了太
鈴木謙三記念医科学応用研究財団研究助成

心臓電気現象の異常を探求し医療の明日を拓く研究, 2023
内藤記念科学奨励金・研究助成

2023
先進医薬研究振興財団循環医学分野研究助成

2023
日本心臓財団拡張型心筋症基礎研究助成（Ｉ基金）

2023
宮田心臓病研究振興基金

2023
MSD生命科学財団研究助成・生活習慣病領域（循環器分野）

2023
理化学研究所奨励課題（個人型発芽研究課題）

2022
循環器病研究振興財団 2022年度バイエル循環器病研究助成

2022
拡張相肥大型心筋症における病的心リモデリング関連分子の同定および機能解析

科学研究費助成事業, 日本学術振興会, Apr, 2017 - Mar, 2018

寺本了太
日本心臓財団・バイエル薬品海外留学助成

2017

Papers

The utility of zebrafish cardiac arrhythmia model to predict the pathogenicity of KCNQ1 variants.

Shihe Cui, Kenshi Hayashi, Isao Kobayashi, Kazuyoshi Hosomichi, Akihiro Nomura, Ryota Teramoto, Keisuke Usuda, Hirofumi Okada, Yaowen Deng, Jingjing Kobayashi-Sun …

Journal of molecular and cellular cardiology, 177 50-61, Mar 8, 2023 Peer-reviewed
Impact of functional studies on exome sequence variant interpretation in early-onset cardiac conduction system diseases.

Kenshi Hayashi, Ryota Teramoto, Akihiro Nomura, Yoshihiro Asano, Manu Beerens, Yasutaka Kurata, Isao Kobayashi, Noboru Fujino, Hiroshi Furusho, Kenji Sakata …

Cardiovascular research, 116(13) 2116-2130, Nov 1, 2020 Peer-reviewedLead author
The endosomal trafficking regulator LITAF controls the cardiac Nav1.5 channel via the ubiquitin ligase NEDD4-2.

Nilüfer N Turan, Karni S Moshal, Karim Roder, Brett C Baggett, Anatoli Y Kabakov, Saroj Dhakal, Ryota Teramoto, David Yi-Eng Chiang, Mingwang Zhong, An Xie …

The Journal of biological chemistry, Oct 22, 2020 Peer-reviewed
Lipoprotein (a) and the Risk of Chronic Kidney Disease in Hospitalized Japanese Patients.

Hayato Tada, Kan Yamagami, Tetsuo Nishikawa, Taiji Yoshida, Ryota Teramoto, Kenji Sakata, Masayuki Takamura, Masa-Aki Kawashiri

Internal medicine (Tokyo, Japan), 59(14) 1705-1710, 2020 Peer-reviewed
Functional analysis of KCNH2 gene mutations of type 2 long QT syndrome in larval zebrafish using microscopy and electrocardiography

Yoshihiro Tanaka, Kenshi Hayashi, Noboru Fujino, Tetsuo Konno, Hayato Tada, Chiaki Nakanishi, Akihiko Hodatsu, Toyonobu Tsuda, Yoji Nagata, Ryota Teramoto …

Heart and Vessels, 34(1) 159-166, Jan, 2019 Peer-reviewed
Oligogenic familial hypercholesterolemia, LDL cholesterol, and coronary artery disease.

Tada H, Kawashiri MA, Nomura A, Teramoto R, Hosomichi K, Nohara A, Inazu A, Mabuchi H, Tajima A, Yamagishi M

Journal of clinical lipidology, 12(6) 1436-1444, Nov, 2018 Peer-reviewed
Duration of cardiopulmonary resuscitation in patients without prehospital return of spontaneous circulation after out-of-hospital cardiac arrest: Results from a severity stratification analysis

Akira Funada, Yoshikazu Goto, Hayato Tada, Ryota Teramoto, Masaya Shimojima, Kenshi Hayashi, Masa-aki Kawashiri, Masakazu Yamagishi

Resuscitation, 124 69-75, Mar 1, 2018 Peer-reviewed
Molecular and functional characterization of familial chylomicronemia syndrome

Ryota Teramoto, Hayato Tada, Masa-aki Kawashiri, Atsushi Nohara, Takuya Nakahashi, Tetsuo Konno, Akihiro Inazu, Hiroshi Mabuchi, Masakazu Yamagishi, Kenshi Hayashi

Atherosclerosis, 269 272-278, Feb 1, 2018 Peer-reviewedLead author
Late gadolinium enhancement for prediction of mutation-positive hypertrophic cardiomyopathy on the basis of panel-wide sequencing

Ryota Teramoto, Noboru Fujino, Tetsuo Konno, Akihiro Nomura, Yoji Nagata, Toyonobu Tsuda, Hayato Tada, Kenji Sakata, Masakazu Yamagishi, Kenshi Hayashi …

Circulation Journal, 82(4) 1139-1148, 2018 Peer-reviewedLead author
Impact of b-type natriuretic peptide level on risk stratification of thromboembolism and death in patients with nonvalvular atrial fibrillation: The hokuriku-plus AF registry

Kenshi Hayashi, Toyonobu Tsuda, Akihiro Nomura, Noboru Fujino, Atsushi Nohara, Kenji Sakata, Tetsuo Konno, Chiaki Nakanishi, Hayato Tada, Yoji Nagata …

Circulation Journal, 82(5) 1271-1278, 2018 Peer-reviewed
J Waves for Predicting Cardiac Events in Hypertrophic Cardiomyopathy

Toyonobu Tsuda, Kenshi Hayashi, Tetsuo Konno, Kenji Sakata, Takashi Fujita, Akihiko Hodatsu, Yoji Nagata, Ryota Teramoto, Akihiro Nomura, Yoshihiro Tanaka …

JACC: Clinical Electrophysiology, 3(10) 1136-1142, Oct 1, 2017 Peer-reviewed
Prehospital cardiopulmonary resuscitation duration and favourable neurological outcome after out-of-hospital cardiac arrest in patients without prehospital return of spontaneous circulation.

A Funada, Y Goto, T Maeda, H Tada, R Teramoto, M Shimojima, K Hayashi, M Yamagishi

Eur Heart J, 37(Suppl-1) 598, Aug, 2017 Peer-reviewed
Age-Specific Differences in the Duration of Prehospital Cardiopulmonary Resuscitation Administered by Emergency Medical Service Providers Necessary to Achieve Favorable Neurological Outcome After Out-of-Hospital Cardiac Arrest

Akira Funada, Yoshikazu Goto, Hayato Tada, Ryota Teramoto, Masaya Shimojima, Kenshi Hayashi, Masakazu Yamagishi

CIRCULATION JOURNAL, 81(5) 652-659, May, 2017 Peer-reviewed
心臓突然死の遺伝的背景早発性心臓伝導障害患者のエクソームシーケンシング(Exome Sequencing for Patients with Early-onset Cardiac Conduction Diseases)

林研至, 野村章洋, 朝野仁裕, 藤野陽, 坂田憲治, 今野哲雄, 多田隼人, 津田豊暢, 寺本了太, 永田庸二 …

日本循環器学会学術集会抄録集, 81回 SY09-5, Mar, 2017
Prehospital predictors of neurological outcomes in out-of-hospital cardiac arrest patients aged 95 years and older: A nationwide population-based observational study

Akira Funada, Yoshikazu Goto, Tetsuo Maeda, Hayato Tada, Ryota Teramoto, Yoshihiro Tanaka, Kenshi Hayashi, Masakazu Yamagishi

JOURNAL OF CARDIOLOGY, 69(1-2) 340-344, Jan, 2017 Peer-reviewed
Age-specific differences in prognostic significance of rhythm conversion from initial non-shockable to shockable rhythm and subsequent shock delivery in out-of-hospital cardiac arrest

Akira Funada, Yoshikazu Goto, Hayato Tada, Ryota Teramoto, Masaya Shimojima, Kenshi Hayashi, Masakazu Yamagishi

RESUSCITATION, 108 61-67, Nov, 2016 Peer-reviewed
Improved Survival With Favorable Neurological Outcome in Elderly Individuals With Out-of-Hospital Cardiac Arrest in Japan - A Nationwide Observational Cohort Study -

Akira Funada, Yoshikazu Goto, Tetsuo Maeda, Ryota Teramoto, Kenshi Hayashi, Masakazu Yamagishi

CIRCULATION JOURNAL, 80(5) 1153-1162, May, 2016 Peer-reviewed
Lipoprotein(a) in Familial Hypercholesterolemia With Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Gain-of-Function Mutations

Hayato Tada, Masa-aki Kawashiri, Taiji Yoshida, Ryota Teramoto, Atsushi Nohara, Tetsuo Konno, Akihiro Inazu, Hiroshi Mabuchi, Masakazu Yamagishi, Kenshi Hayashi

CIRCULATION JOURNAL, 80(2) 512-+, Feb, 2016 Peer-reviewed
Usefulness of Electrocardiographic Voltage to Determine Myocardial Fibrosis in Hypertrophic Cardiomyopathy

Tetsuo Konno, Yoji Nagata, Ryota Teramoto, Noboru Fujino, Akihiro Nomura, Hayato Tada, Kenji Sakata, Hiroshi Furusho, Masayuki Takamura, Hiroyuki Nakamura …

AMERICAN JOURNAL OF CARDIOLOGY, 117(3) 443-449, Feb, 2016 Peer-reviewed
Whole exome sequencing combined with integrated variant annotation prediction identifies a causative myosin essential light chain variant in hypertrophic cardiomyopathy

Akihiro Nomura, Hayato Tada, Ryota Teramoto, Tetsuo Konno, Akihiko Hodatsu, Hong-Hee Won, Sekar Kathiresan, Hidekazu Ino, Noboru Fujino, Masakazu Yamagishi …

JOURNAL OF CARDIOLOGY, 67(1-2) 133-139, Jan, 2016 Peer-reviewedLead author

Misc.

若年発症心臓刺激伝導障害の稀な遺伝子多型の病的意義決定における機能解析の有用性

林研至, 野村章洋, 寺本了太, 朝野仁裕, 倉田康孝, 藤野陽, 古荘浩司, 坂田憲治, 加藤武史, 多田隼人 …

日本人類遺伝学会大会プログラム・抄録集, 64th, 2019
心肺蘇生ガイドライン2020への挑戦小児院外心停止に対する胸骨圧迫のみCPRと標準的CPRの転帰比較

後藤由和, 舟田晃, 前田哲生, 寺本了太, 多田隼人, 高島伸一郎

日本救急医学会雑誌, 28(9) 427-427, Sep, 2017
網羅的遺伝子解析が診断確定に有用であったABCG8遺伝子複合ヘテロ変異によるシトステロール血症の1例

山本幸代, 寺本了太, 多田隼人, 後藤元秀, 荒木俊介, 久保和康, 川越倫子, 楠原浩一

The Lipid, 28(2) 208-209, Apr, 2017
心筋症と突然死

藤野陽, 今野哲雄, 林研至, 寺本了太, 山岸正和

循環器内科, 79(2) 90-94, Feb 1, 2016
心筋症遺伝子のコホート研究

藤野陽, 今野哲雄, 林研至, 寺本了太, 山岸正和

Heart View, 20(2), Feb, 2016
Risk-SCD calculatorを用いた肥大型心筋症の予後予測に関する検討 Fragmented QRS complexによるリスク再層別化の試み

寺本了太, 今野哲雄, 田中仁啓, 多田隼人, 津田豊暢, 坂田憲治, 林研至, 藤野陽, 川尻剛照, 山岸正和

日本心臓病学会学術集会抄録, 63回 710-710, Sep, 2015
Fragmented QRS improves prediction ability of the Risk-SCD calculator for sudden cardiac death in Japanese patients with hypertrophic cardiomyopathy

R. Teramoto, T. Konno, H. Tada, T. Tsuda, A. Hodatsu, K. Sakata, K. Hayashi, N. Fujino, M. Kawashiri, M. Yamagishi

EUROPEAN HEART JOURNAL, 36 104-104, Aug, 2015
The diagnosis and management of familial hypertrophic cardiomyopathy: from a viewpoint of genetic analyses

Ryota Teramoto

77(4) 294-302, Apr, 2015
肥大型心筋症

藤野陽, 林研至, 今野哲雄, 坂田憲治, 藤田崇志, 宝達明彦, 津田豊暢, 永田庸二, 多田隼人, 寺本了太 …

日本心臓病学会学術集会(Web), 63rd, 2015
心臓手術周術期に認めた心室中隔内血腫の一例

高嶋勇志, 田中仁啓, 岡田寛史, 森雅之, 吉田昌平, 中橋卓也, 永田庸二, 寺本了太, 津田豊暢, 森三佳 …

日本循環器学会北陸地方会(Web), 129th, 2014
不適切な加圧トレーニングが発症要因として疑われた深部静脈血栓症に伴う肺血栓塞栓症の一例

寺本了太, 松原隆夫, 安田敏彦, 三輪健二, 井上勝, 木下晴之, 岡田寛史, 役田洋平, 松井崇生, 金谷法忍

日本心臓病学会誌, 7(Suppl.I) 292-292, Aug, 2012
The Impact of distal protection device (Filtrap) in Percutaneous Coronary Intervention with Consecutive 120 Coronary Artery Disease Patients.

Teramoto R, Miwa K, Matsubara T, Yasuda T, Inoue M, Okada H, Kanaya H

The Medical journal of Ishikawa Prefectural Central Hospital, 34 19-23, 2012
石川県立中央病院におけるカテーテルアブレーションの現状

井上勝, 松原隆夫, 安田敏彦, 三輪健二, 寺本了太, 吉田昌平, 岡田寛史, 金谷法忍

石川県立中央病院医学誌, 33 29-31, Sep, 2011
脳梗塞を契機に診断したPlatypnea Orthodeoxia Syndromeの一例

吉田昌平, 南部早和, 松原隆夫, 安田敏彦, 三輪健二, 井上勝, 寺本了太, 岡田寛史, 役田洋平, 金谷法忍 …

日本心臓病学会誌, 6(Suppl.I) 310-310, Aug, 2011
Peripartum cardiomyopathy could be treated with intensive care: A report of two cases

Yoshida Shohei, Matsubara Takao, Yasuda Toshihiko, Miwa Kenji, Inoue Masaru, Teramoto Ryouta, Okada Hirohumi, Kanaya Hounin

Shinzo, 43(8) 1089-1094, Aug, 2011
Predictive Factor for New-Onset Atrial Arrhythmia after Surgical Repair of Atrial Septal Defects. Follow-Up at 10 to 20 Years

Ryota Teramoto, Masaru Inoue, Takao Matsubara, Toshihiko Yasuda, Kenji Miwa, Honin Kanaya, Makoto Tsubota

Journal of Arrhythmia, 27(4) 284, 2011 Peer-reviewed
SES、PES、BMSの3種類のステント留置後に突然死した1剖検例 OCTならびに病理組織学的検討

三輪健二, 松原隆夫, 安田敏彦, 井上勝, 寺本了太, 吉田昌平, 岡田寛史, 金谷法忍, 井上勝美, 川尻剛照 …

日本心臓病学会誌, 5(Suppl.I) 322-322, Aug, 2010
薬剤溶出性ステント留置後におけるperi-stent restenosisとプラーク組織性状との関連 VH-IVUSによる検討

三輪健二, 松原隆夫, 安田敏彦, 井上勝, 寺本了太, 吉田昌平, 岡田寛史, 金谷法忍, 川尻剛照, 井野秀一 …

日本心臓病学会誌, 5(Suppl.I) 412-412, Aug, 2010

Presentations

2020年度ノーベル賞「神の鋏」CRISPR-Cas9を知る!編

寺本了太

Antaa クローズアップGENOME 第3回, Dec 8, 2020 Invited
ゼブラフィッシュを用いた心筋症・不整脈関連遺伝子の機能解析 −心不全オミックス研究への展望−

寺本了太

理化学研究所生命医科学研究センターセミナー, Nov 19, 2020
Lamin A Deficiency Leads To Electrophysiological And Nuclear Abnormalities Reminiscent Of Atrial Cardiomyopathy In Zebrafish

Ryota Teramoto, Kenshi Hayashi, Manu Beerens, David Chiang, Tuomas O Kiviniemi, Masahiro Satoh, Ashmita KC, Micah Burch, Wandi Zhu, Wei Dai, Jing Liu, Aparna Mahadevan, Eva Buys, Calum MacRae

AHA (American Heart Association) 2020 (Dallas, Virtual ), Best of Genetics and Genomics: Oral Abstract Presentation, Nov 13, 2020
Molecular and functional characterization of cardiovascular disease using zebrafish

Ryota Teramoto

Lecture in the Laboratory of Genetics and Molecular Cardiology, University of São Paulo, Brazil (Online), Nov 6, 2020 Invited
Lamin A Deficiency Leads to Electrophysiological and Nuclear Abnormalities Mimicking Atrial Cardiomyopathy

Ryota Teramoto

2020 Alan Lerner Research Symposium, Sep 3, 2020
Recent Progress in Genetic Testing for Dilated Cardiomyopathy

寺本了太

第84回日本循環器学会学術集会（京都・オンライン）, Jul, 2020 Invited
Disruption of Lamin A Leads to Early-onset Cardiac Conduction Dysfunction in Zebrafish Model of Laminopathy

Ryota Teramoto, Kenshi Hayashi, Manu Beerens, Micah Burch, David Chiang, Aaron P. Kithcart, Yao Zu, Tuomas Kiviniemi, Eva Buys, Akihiro Nomura, Masayuki Takamura, Calum A. MacRae

The 71st ACC (American College of Cardiology) Scientific Sessions 2020, Mar, 2020
Impact of Distal Protection with Filter-Type Device on Long-term Outcome after Percutaneous Coronary Intervention for Acute Myocardial Infarction: Clinical Results with Filtrap®

Ryota Teramoto

Jul 7, 2017 Invited
Comprehensive Approach Identifying Causative Mutations in Patients with Hypertrophic Cardiomyopathy Using Next Generation Sequencing Panels

Ryota Teramoto, Tetsuo Konno, Hayato Tada, Kenshi Hayashi, Noboru Fujino, Masa-aki Kawashiri, Masakazu Yamagishi

Mar 18, 2017
Prognostic significance of non-MYBPC3 genotype in familial hypertrophic cardiomyopathy

Ryota Teramoto

Mar 17, 2017
次世代シーケンスによる候補遺伝子パネルを用いた肥大型心筋症の原因遺伝子解析

寺本了太

第2回日本心筋症研究会（日本心不全学会分科会）（松本）会長推薦演題平成28年度厚生労働科学研究費補助金難治性疾患等政策研究事業（難治性疾患政策研究事業）特発性心筋症に関する調査研究平成28年度総会・研究報告会, May 14, 2016
Comprehensive Approach Identifying Causative Mutations in Patients with Familial Hyperchylomicronemia Using a Next Generation Sequencing Panel

Teramoto R, Tada H, Kawashiri MA, Nohara N, Inazu A, Mabuchi H, Yamagishi Y

Mar 18, 2016
Targeted sequencing panel focusing on 21cardiomyopathy-associated genes efficiently identifies disease-causingvariants in patients with hypertrophic cardiomyopathy

Ryota Teramoto

Mar 18, 2016
Comprehensive Approach Identifying Disease-causing Variants in Patients with Hypertrophic Cardiomyopathy Using a Targeted Sequencing Panel Focusing on 21 Cardiomyopathy-associated Genes

Ryota Teramoto, Noboru Fujino, Hayato Tada, Tetsuo Konno, Yoshihiro Tanaka, Youji Nagata, Toyonobu Tsuda, Kenji Sakata, Kenshi Hayashi, Hidekazu Ino, Masa-aki Kawashiri, Masakazu Yamagishi

The 88th AHA Scientific Sessions 2015 (Orlando, USA), Nov 10, 2015
Risk-SCD calculator を用いた肥大型心筋症の予後予測に関する検討～ Fragmented QRS complex によるリスク再層別化の試み～

寺本了太, 今野哲雄, 田中仁啓, 多田隼人, 津田豊暢, 坂田憲治, 林研至, 藤野陽, 川尻剛照, 山岸正和

第63回日本心臓病学会学術集会, Sep 19, 2015
Fragmented QRS improves prediction ability of the Risk-SCD calculator for sudden cardiac death in Japanese patients with hypertrophic cardiomyopathy

R. Teramoto, T. Konno, H. Tada, T. Tsuda, A. Hodatsu, K. Sakata, K. Hayashi, N. Fujino, M. Kawashiri, M. Yamagishi

The 29th ESC Congress 2015 (London, UK), Aug 15, 2015
12誘導心電図におけるFragmented QRSは肥大型心筋症における心不全発症を予測する

寺本了太, 野村章洋, 今野哲雄, 藤野陽, 山岸正和

平成26年度厚生労働科学研究費補助金難治性疾患等政策研究事業（難治性疾患政策研究事業）特発性心筋症に関する調査研究平成26年度総会・研究報告会（東京大学病院）, Oct 30, 2014
新規DPP-4阻害薬リナグリプチン投与例における心機能変化に関する検討

寺本了太, 森三佳, 吉牟田剛, 坂田憲治, 林研至, 川尻剛照, 山岸正和

第62回日本心臓病学会学術集会（仙台）, Sep 26, 2014
新規DPP-4阻害薬リナグリプチン投与例における心機能変化に関する検討

寺本了太, 森三佳, 吉牟田剛, 坂田憲治, 林研至, 川尻剛照, 山岸正和

第25回日本心エコー図学会学術集会（金沢）, Apr 17, 2014
高度な石灰化病変に対してIVUSガイド下にVAIVTを施行した1例

寺本了太

第8回北陸VAIVT研究会, Sep 14, 2013

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市民公開講座心臓病から命を守る：狭心症・心筋梗塞との付き合い方

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Mar 21, 2015 - Mar 21, 2015

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