Ryuichi Kimura

Profile Information

Affiliation: Kyoto University

Degree: 医学博士(Sep, 2015, 東北大学)

J-GLOBAL ID: 201201038183857968
researchmap Member ID: B000222457

Research Interests

Research Areas

Life sciences / Developmental biology /

Research History

Apr, 2020 - Present

Kyoto University Graduate School of Medicine
Oct, 2015 - Mar, 2020

Tohoku University Graduate School of Medicine

Papers

Structural and molecular properties of mumps virus inclusion bodies.

Hiroshi Katoh, Ryuichi Kimura, Tsuyoshi Sekizuka, Kohei Matsuoka, Mika Hosogi, Yuki Kitai, Yukiko Akahori, Fumihiro Kato, Michiyo Kataoka, Hirotaka Kobayashi …

Science advances, 10(49) eadr0359, Dec 6, 2024
A Transcriptomic Dataset of Embryonic Murine Telencephalon

Shohei Ochi, Shyu Manabe, Takako Kikkawa, Sara Ebrahimiazar, Ryuichi Kimura, Kaichi Yoshizaki, Noriko Osumi

Scientific Data, 11(1), Jun 5, 2024
Advanced paternal age diversifies individual trajectories of vocalization patterns in neonatal mice

Lingling Mai, Hitoshi Inada, Ryuichi Kimura, Kouta Kanno, Takeru Matsuda, Ryosuke O. Tachibana, Valter Tucci, Fumiyasu Komaki, Noboru Hiroi, Noriko Osumi

iScience, 104834-104834, Aug, 2022
Photo-isolation chemistry for high-resolution and deep spatial transcriptome with mouse tissue sections.

Mizuki Honda, Ryuichi Kimura, Akihito Harada, Kazumitsu Maehara, Kaori Tanaka, Yasuyuki Ohkawa, Shinya Oki

STAR protocols, 3(2) 101346-101346, Jun 17, 2022
Detection of REST expression in the testis using epitope‐tag knock‐in mice generated by genome editing

Ryuichi Kimura, Yukiko U. Inoue, Takako Kikkawa, Misako Tatehana, Yuki Morimoto, Hitoshi Inada, Shinya Oki, Takayoshi Inoue, Noriko Osumi

Developmental Dynamics, 251(3) 525-535, Sep 20, 2021
父加齢が子孫の行動や遺伝子発現に与える影響は精子DNA低メチル化の継承が原因である可能性がある

大隅典子, 吉崎嘉一, 木村龍一, 沖真弥, 吉川貴子, Mai Lingling, 稲田仁

DOHaD研究, 9(1) 40-40, Sep, 2021
父親マウスの加齢が新生仔マウスの超音波発声行動に与える影響機械学習を用いた個性研究の試み

稲田仁, 麦玲玲, 木村龍一, 吉崎嘉一, 大隅典子

DOHaD研究, 9(1) 69-69, Sep, 2021
High-depth spatial transcriptome analysis by photo-isolation chemistry.

Mizuki Honda, Shinya Oki, Ryuichi Kimura, Akihito Harada, Kazumitsu Maehara, Kaori Tanaka, Chikara Meno, Yasuyuki Ohkawa

Nature communications, 12(1) 4416-4416, Jul 20, 2021
Paternal age affects offspring via an epigenetic mechanism involving REST/NRSF.

Kaichi Yoshizaki, Ryuichi Kimura, Hisato Kobayashi, Shinya Oki, Takako Kikkawa, Lingling Mai, Kohei Koike, Kentaro Mochizuki, Hitoshi Inada, Yasuhisa Matsui …

EMBO reports, 22(2) e51524, Feb 3, 2021
"Passenger gene" problem in transgenic C57BL/6 mice used in hearing research.

Jun Suzuki, Hitoshi Inada, Chul Han, Mi-Jung Kim, Ryuichi Kimura, Yusuke Takata, Yohei Honkura, Yuji Owada, Tetsuaki Kawase, Yukio Katori …

Neuroscience research, 158 6-15, Sep, 2020
The Autism-Related Protein SETD5 Controls Neural Cell Proliferation through Epigenetic Regulation of rDNA Expression.

Tadashi Nakagawa, Satoko Hattori, Risa Nobuta, Ryuichi Kimura, Makiko Nakagawa, Masaki Matsumoto, Yuko Nagasawa, Ryo Funayama, Tsuyoshi Miyakawa, Toshifumi Inada …

iScience, 23(4) 101030-101030, Apr 24, 2020
Comprehensive histochemical profiles of histone modification in male germline cells during meiosis and spermiogenesis: Comparison of young and aged testes in mice.

Misako Tatehana, Ryuichi Kimura, Kentaro Mochizuki, Hitoshi Inada, Noriko Osumi

PloS one, 15(4) e0230930, 2020
Correction: Early postnatal vocalizations predict sociability and spatial memory in C57BL/6J mice: Individual differences in behavioral traits emerge early in development.

Kaichi Yoshizaki, Kohei Koike, Ryuichi Kimura, Noriko Osumi

PloS one, 13(1) e0191702, 2018
Risk of Neurodevelopmental Disease by Paternal Aging: A Possible Influence of Epigenetic Alteration in Sperm.

Ryuichi Kimura, Kaichi Yoshizaki, Noriko Osumi

Advances in experimental medicine and biology, 1012 75-81, 2018
Early postnatal vocalizations predict sociability and spatial memory in C57BL/6J mice: Individual differences in behavioral traits emerge early in development.

Kaichi Yoshizaki, Kohei Koike, Ryuichi Kimura, Noriko Osumi

PloS one, 12(11) e0186798, 2017 Peer-reviewed
Paternal Aging Affects Behavior in Pax6 Mutant Mice: A Gene/Environment Interaction in Understanding Neurodevelopmental Disorders.

Kaichi Yoshizaki, Tamio Furuse, Ryuichi Kimura, Valter Tucci, Hideki Kaneda, Shigeharu Wakana, Noriko Osumi

PloS one, 11(11) e0166665, 2016
雄性生殖細胞系列におけるPax6の発現 Pax6の新規機能

木村龍一, 吉崎嘉一, 小池航平, 稲田仁, 大隅典子

日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 88回・38回 [1P0905]-[1P0905], Dec, 2015
父親のPax6ハプロ不全は加齢による仔マウスの言語コミュニケーション障害を早期に生じさせる(Paternal Pax6 haploinsufficiency accelerate vocal communication deficits by advanced paternal aging)

吉崎嘉一, 木村龍一, 小池航平, 稲田仁, 大隅典子

日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集, 37回・45回 196-196, Sep, 2015
Dynamic expression patterns of Pax6 during spermatogenesis in the mouse.

Ryuichi Kimura, Kaichi Yoshizaki, Noriko Osumi

Journal of anatomy, 227(1) 1-9, Jul, 2015
Preservation of cochlear function in Fabp3 (H-Fabp) knockout mice

Jun Suzuki, Takeshi Oshima, Naohiro Yoshida, Ryuichi Kimura, Yusuke Takata, Yuji Owada, Toshimitsu Kobayashi, Yukio Katori, Noriko Osumi

Neuroscience Research, 81-82 64-68, Apr, 2014

Misc.

Expression Changes of REST/NRSF in Spermatogenesis from Neonatal to Adult Murine Testis

MAINS-SHEARD John, TATEHANA Misako, INADA Hitoshi, INADA Hitoshi, KIKKAWA Takako, KIMURA Ryuichi, INOUE Yukiko, MORIMOTO Yuki, OKI Shinya, INOUE Takayoshi …

日本分子生物学会年会プログラム・要旨集(Web), 44th, 2021
父親の加齢はマウス新生仔における発声コミュニケーションの非典型的発達の原因となる(Paternal aging causes atypical development of vocal communication in neonatal mice)

麦玲玲, 木村龍一, 稲田仁, 大隅典子

日本神経精神薬理学会年会・日本生物学的精神医学会年会・日本精神薬学会総会・学術集会合同年会プログラム・抄録集, 50回・42回・4回 208-208, Aug, 2020
【DOHaD-われわれの健康と疾患リスクは胎生期・発達期の環境でどこまで決まるのか?】老化による精子の変化と発達障害発症リスク

舘花美沙子, 木村龍一, 大隅典子

実験医学, 38(6) 932-936, Apr, 2020
マウスの雄性生殖系列細胞におけるヒストン修飾の加齢による変化

舘花美沙子, 木村龍一, 木村龍一, 大隅典子

日本分子生物学会年会プログラム・要旨集(Web), 43rd, 2020
【エピゲノム医療】エピゲノムの経世代影響

木村龍一, 吉崎嘉一, 大隅典子

遺伝子医学, 10(1) 68-73, Jan, 2020
Possible risk of autism spectrum disorder through epigenetic inheritance

木村龍一, 稲田仁, 大隅典子

医学のあゆみ, 268(3) 180-183, Jan 19, 2019
PATERNAL AGE AFFECTS OFFSPRING'S BEHAVIOR POSSIBLY VIA EPIGENETIC MECHANISM RECRUITING A TRANSCRIPTIONAL REPRESSOR REST

Kaichi Yoshizaki, Ryuichi Kimura, Kentaro Mochizuki, Takako Kikkawa, Hitoshi Inada, Niroko Osumi

EUROPEAN NEUROPSYCHOPHARMACOLOGY, 29 S831-S831, 2019
精子におけるエピゲノム修飾と次世代への影響

大隅典子, 木村龍一, Mai Lingling, 舘花美沙子, 吉川貴子, 望月研太郎, 稲田仁

DOHaD研究, 8(3) 30-30, 2019
雄性生殖系列細胞におけるヒストン修飾の分子的特徴

舘花美沙子, 木村龍一, 大隅典子

生命科学系学会合同年次大会, 2017年度 [2LBA-073], Dec, 2017
【エピジェネティクスと臨床-DOHaD学説のインパクト】父加齢・エピゲノム・精神疾患

大隅典子, 木村龍一

Medical Science Digest, 43(12) 612-615, Nov, 2017
父加齢が次世代の行動に影響を与えるエピジェネティックなメカニズム:新たな自閉スペクトラム症モデルの提案

吉崎嘉一, 小池佐, 木村龍一, 吉川貴子, 沖真弥, 沖真弥, 稲田仁, 松居靖之, 河野友宏, 大隅典子

日本解剖学会総会・全国学術集会講演プログラム・抄録集, 122nd, 2017
【エピゲノムの遺伝】精子形成過程におけるエピゲノム修飾と次世代への影響

大隅典子, 木村龍一

BIO Clinica, 31(5) 470-474, May, 2016
A Sensitive Period for GABAergic Interneurons in the Dentate Gyrus in Modulating Sensorimotor Gating (April, pg 6691, 2013)

Nannan Guo, Kaichi Yoshizaki, Ryuichi Kimura, Fumikazu Suto, Yuchio Yanagawa, Noriko Osumi

JOURNAL OF NEUROSCIENCE, 35(18) 7312-7312, May, 2015
脂肪酸結合タンパク質(Fabp)の蝸牛における機能解析加齢性難聴になりにくいマウスの発見

鈴木淳, 大島猛史, 吉田尚弘, 木村龍一, 吉崎嘉一, 高田雄介, 大和田祐二, 小林俊光, 大隅典子

日本抗加齢医学会総会プログラム・抄録集, 13回 201-201, Jun, 2013
Fabp7, a brain specific fatty acid binding protein, regulates proliferation of oligodendrocyte precursor cells

Ryuichi Kimura, Kaichi Yoshizaki, Youko Matsumoto, Yuji Tsunekawa, Noriko Osumi

NEUROSCIENCE RESEARCH, 71 E328-E328, 2011

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