Ryuichi Ohgaki

Profile Information

Affiliation: Graduate School of Medicine, Osaka University

Degree: 博士(理学)(大阪大学)

Researcher number: 20467525
J-GLOBAL ID: 201101040484890062
researchmap Member ID: 6000029798

External link: http://www.pharma1.med.osaka-u.ac.jp/

Research Interests

Research Areas

Research History

Mar, 2021 - Present

大阪大学大学院医学系研究科准教授
Sep, 2020 - Present

生命医科学融合フロンティア研究部門（兼任）, 大阪大学先導的学際研究機構
Apr, 2016 - Feb, 2021

大阪大学大学院医学系研究科学部内講師
Apr, 2009 - Feb, 2021

大阪大学大学院医学系研究科助教
Mar, 2009 - Mar, 2009

Postdoctral fellow, Graduate School of Medicine, Osaka University
Feb, 2008 - Feb, 2009

Visiting research felllow, University Medical Center Groningen, Groningen University
Nov, 2007 - Feb, 2009

Postdoctral fellow, Graduate School of Science, Osaka University

Education

Apr, 2004 - Oct, 2007

Department of Biological Science, PhD course, Graduate School of Science, Osaka University
Apr, 2002 - Mar, 2004

Department of Biological Science, MS course, Graduate School, Division of Natural Science, Osaka University
Apr, 1998 - Mar, 2002

Department of Biological Science, Faculty of Science, Osaka University

Committee Memberships

Mar, 2024 - Present

Discover Oncology, Editorial Borad Member
Apr, 2016 - Present

学術評議員, 公益社団法人日本薬理学会

Awards

Dec, 2022

令和4年度膵臓病研究奨励賞, 公益財団法人日本膵臓病研究財団

大垣隆一
Sep, 2012

第3回分子腎臓フォーラム優秀賞

大垣隆一
Sep, 2006

The 21st COE Program Research Assistant Progress Report Best Poster Award, Biological Science/Institute for Protein Research, Graduate School of Science, Osaka University

大垣隆一
Mar, 2002

楠本賞, 大阪大学

大垣隆一

Papers

Upregulation of ATF4 mediates the cellular adaptation to pharmacologic inhibition of amino acid transporter LAT1 in pancreatic ductal adenocarcinoma cells

Yu Ma, Suguru Okuda, Hiroki Okanishi, Minhui Xu, Chunhuan Jin, Hitoshi Endou, Ryuichi Ohgaki, Yoshikatsu Kanai

Journal of Pharmacological Sciences, 155(1) 14-20, May, 2024 Peer-reviewed
Identification of tumor-suppressive miRNAs that target amino acid transporter LAT1 and exhibit anti-proliferative effects on cholangiocarcinoma cells

Xingming Liu, Kou Nishikubo, Ryuichi Ohgaki, Hiroki Okanishi, Suguru Okuda, Minhui Xu, Yoshikatsu Kanai

Journal of Pharmacological Sciences, 154(4) 301-311, Apr, 2024 Peer-reviewedCorresponding author
Inhibition of amino acid transporter LAT1 in cancer cells suppresses G0/G1-S transition by downregulating cyclin D1 via p38 MAPK activation

Xinyu Zhou, Ryuichi Ohgaki, Chunhuan Jin, Minhui Xu, Hiroki Okanishi, Hitoshi Endou, Yoshikatsu Kanai

Journal of Pharmacological Sciences, 154(3) 182-191, Mar, 2024 Peer-reviewedCorresponding author
Structure–activity characteristics of phenylalanine analogs selectively transported by L-type amino acid transporter 1 (LAT1)

Sihui Chen, Chunhuan Jin, Ryuichi Ohgaki, Minhui Xu, Hiroki Okanishi, Yoshikatsu Kanai

Scientific Reports, 14(1) 4651, Feb 26, 2024 Peer-reviewed
Evaluation of LAT1 Expression in Patients With Lung Cancer and Mediastinal Tumors: 18F-FBPA PET Study With Immunohistological Comparison.

Tadashi Watabe, Naoko Ose, Sadahiro Naka, Eriko Fukui, Toru Kimura, Takashi Kanou, Soichiro Funaki, Hidetaka Sasaki, Takashi Kamiya, Kenta Kurimoto …

Clinical nuclear medicine, 48(10) 853-860, Oct 1, 2023 Peer-reviewed
The Clinical Potential of FBPA-PET/CT Imaging for Colorectal Cancer and its Liver Metastases Expressing LAT1.

Takayuki Minoji, Hidekazu Takahashi, Tadashi Watabe, Satoshi Ishikawa, Hiroki Kato, Ryuichi Ohgaki, Yoshikatsu Kanai, Yuki Sekido, Tsuyoshi Hata, Atsushi Hamabe …

Anticancer research, 43(9) 3913-3921, Sep, 2023 Peer-reviewed
Inhibition of Cancer-type Amino Acid Transporter LAT1 Suppresses B16-f10 Melanoma Metastasis in Mouse Models.

Zitong Shi, Kazuko Kaneda-Nakashima, Ryuichi Ohgaki, Minhui Xu, Hiroki Okanishi, Hitoshi Endou, Shushi Nagamori, Yoshikatsu Kanai

Scientific Reports, 13(1) 13943-13943, Aug 25, 2023 Peer-reviewed
Combination effects of amino acid transporter LAT1 inhibitor nanvuranlat and cytotoxic anticancer drug gemcitabine on pancreatic and biliary tract cancer cells.

Kou Nishikubo, Ryuichi Ohgaki, Xingming Liu, Hiroki Okanishi, Minhui Xu, Hitoshi Endou, Yoshikatu Kanai

Cancer Cell International, 23(1) 116, Jun, 2023 Peer-reviewedCorresponding author
LAT1 expression influences Paneth cell number and tumor development in ApcMin/+ mice

Yunlong Sui, Namiko Hoshi, Ryuichi Ohgaki, Lingling Kong, Ryutaro Yoshida, Norihiro Okamoto, Masato Kinoshita, Haruka Miyazaki, Yuna Ku, Eri Tokunaga …

Journal of Gastroenterology, Feb 5, 2023 Peer-reviewed
Phosphoproteomics revealed cellular signals immediately responding to disruption of cancer amino acid homeostasis induced by inhibition of l-type amino acid transporter 1

Hiroki Okanishi, Ryuichi Ohgaki, Minhui Xu, Hitoshi Endou, Yoshikatsu Kanai

Cancer & Metabolism, 10(1) 18-18, Nov 10, 2022 Peer-reviewed
Pharmacologic inhibition of LAT1 predominantly suppresses transport of large neutral amino acids and downregulates global translation in cancer cells

Kou Nishikubo, Ryuichi Ohgaki, Hiroki Okanishi, Suguru Okuda, Minhui Xu, Hitoshi Endou, Yoshikatsu Kanai

Journal of Cellular and Molecular Medicine, 26(20) 5246-5256, Oct, 2022 Peer-reviewedCorresponding author
Structural insights into inhibitory mechanism of human excitatory amino acid transporter EAAT2

Takafumi Kato, Tsukasa Kusakizako, Chunhuan Jin, Xinyu Zhou, Ryuichi Ohgaki, LiLi Quan, Minhui Xu, Suguru Okuda, Kan Kobayashi, Keitaro Yamashita …

Nature Communications, 13(1) 4714, Aug 11, 2022 Peer-reviewed
Functional coupling of organic anion transporter OAT10 (SLC22A13) and monocarboxylate transporter MCT1 (SLC16A1) influencing the transport function of OAT10

Naoko Ohtsu, Ryuichi Ohgaki, Chunhuan Jin, Minhui Xu, Hiroki Okanishi, Ryo Takahashi, Akiko Matsui, Wataru Kishimoto, Naoki Ishiguro, Yoshikatsu Kanai

Journal of Pharmacological Sciences, 150(1) 41-48, Jun 17, 2022 Peer-reviewed
Proteomics and phosphoproteomics reveal key regulators associated with cytostatic effect of amino acid transporter LAT1 inhibitor

Hiroki Okanishi, Ryuichi Ohgaki, Suguru Okuda, Hitoshi Endou, Yoshikatsu Kanai

Cancer Science, 112(2) 871-883, Dec 19, 2020 Peer-reviewed
Amino acid transporter LAT1 in tumor-associated vascular endothelium promotes angiogenesis by regulating cell proliferation and VEGF-A-dependent mTORC1 activation

Lili Quan, Ryuichi Ohgaki, Saori Hara, Suguru Okuda, Ling Wei, Hiroki Okanishi, Shushi Nagamori, Hitoshi Endou, Yoshikatsu Kanai

Journal of Experimental & Clinical Cancer Research, 39(1) 266, Dec, 2020 Peer-reviewedLead author
A novel mutation in the SLCO2A1 gene, encoding a prostaglandin transporter, induces chronic enteropathy

Keisuke Jimbo*, Toshiaki Okuno*, Ryuichi Ohgaki*, Kou Nishikubo, Yuri Kitamura, Yumiko Sakurai, Lili Quan, Hiromichi Shoji, Yoshikatsu Kanai, Toshiaki Shimizu …

PLOS ONE, 15(11) e0241869-e0241869, Nov 9, 2020 Peer-reviewedLead author
Interaction of halogenated tyrosine/phenylalanine-derivatives with Organic Anion Transporter (OAT) 1 in the renal handling of tumor imaging probes

Chunhuan Jin, Ling Wei, Ryuichi Ohgaki, Hideyuki Tominaga, Minhui Xu, Suguru Okuda, Hiroki Okanishi, Yasuharu Kawamoto, Xin He, Shushi Nagamori …

Journal of Pharmacology and Experimental Therapeutics, 375(3) 451-462, Sep 27, 2020 Peer-reviewed
Cryo-EM structure of the human L-type amino acid transporter 1 in complex with glycoprotein CD98hc.

Lee Y, Wiriyasermkul P, Jin C, Quan L, Ohgaki R, Okuda S, Kusakizako T, Nishizawa T, Oda K, Ishitani R …

Nature structural & molecular biology, 26(6) 510-517, Jun, 2019 Peer-reviewed
Boron delivery for boron neutron capture therapy targeting a cancer-upregulated oligopeptide transporter.

Miyabe J, Ohgaki R, Saito K, Wei L, Quan L, Jin C, Liu X, Okuda S, Nagamori S, Ohki H …

Journal of pharmacological sciences, 139(3) 215-222, Mar, 2019 Peer-reviewed
Ratiometric fluorescence imaging of cell surface pH by poly(ethylene glycol)-phospholipid conjugated with fluorescein isothiocyanate

Ryuichi Ohgaki, Yuji Teramura, Daichi Hayashi, Lili Quan, Suguru Okuda, Shushi Nagamori, Madoka Takai, Yoshikatsu Kanai

SCIENTIFIC REPORTS, 7(1) 17484, Dec, 2017 Peer-reviewedLead author

Misc.

アミノ酸トランスポーター阻害薬によるがん治療 -研究の展開と解明が進むユニークな抗腫瘍効果の発現機序-

大垣隆一

日本応用酵素協会誌, 56 21-28, Mar, 2022 InvitedLead authorCorresponding author
Cell surface pH imaging using poly(ethylene glycol)-phospholipid: its potential as the core structure of membrane anchored-probes

大垣隆一, 寺村裕治, 林大智, 永森收志, 永森收志, 高井まどか, 金井好克

日本薬理学雑誌, 153(6) 254-260, Jun, 2019 Peer-reviewedInvited
アミノ酸シグナルの解明からがん治療へ -アミノ酸トランスポーター阻害によるがん代謝制御-

大垣隆一, 金井好克

実験医学, 37(4) 508-513, Mar, 2019 InvitedLead author
Amino acid transporter chaperons its fusogenic partner: an essential role in placenta, and its implications for physiological and pathological cell fusion

Ryuichi Ohgaki, Yoshikatsu Kanai

Atlas of Science (http://atlasofscience.org/), Jan, 2018
ロイシンセンサーの分子実体の発見とそれによるmTORC1の活性制御

大垣隆一

ファルマシア, 52(7) 696-696, Jul, 2016 Invited
L-型アミノ酸トランスポーター1(LAT1)による輸送と哺乳類ラパマイシン標的タンパク質(mTOR)活性化のためのロイシン誘導体の構造的必要性(The structural requirements of leucine derivatives to be transported by L-type amino acid transporter 1(LAT1) and to activate mammalian target of rapamycin(mTOR))

Wiriyasermkul Pattama, 永森收志, 木村徹, 大垣隆一, 金井好克

日本薬理学雑誌, 137(3) 31P-31P, Mar, 2011
Localization, ion transport activity, and physiological function of mammalian organellar NHEs

Ohgaki R, Matsushita M, Kanazawa H

82(7) 577-590, Jul, 2010 InvitedLead author

Presentations

143

がん細胞におけるアミノ酸トランスポーターLAT1の阻害はp38 MAPK活性化を介したサイクリンD1の下方制御によりG0/G1期からS 期への移行を抑制する

Zhou Xinyu, 大垣隆一, Jin Chunhuan, Xu Minhui, 岡西広樹, 遠藤仁, 金井好克

第144回日本薬理学会近畿部会, Mar 20, 2024
Mechanisms of the inhibition of cancer cell proliferation by LAT1 inhibitors revealed by the changes in the intracellular concentrations and function of individual amino acids

Dec 15, 2023
Functional coupling with endogenous monocarboxylic acid transporter MCT1 influences on transport function of exogenously expressed organic anion transporter OAT10 in HEK293 cells: a warning on transporter assays

Dec 14, 2023
Effects of the accumulation of hypoxia-inducible factors on the expression of L-type amino acid transporter LAT1 in colorectal cancer cells

Dec 14, 2023
Structural basis for inhibition of human excitatory amino acid transporter EAAT2 by WAY-213613

Takafumi Kato, ○Tsukasa Kusakizako, Ryuichi Ohgaki, Yoshikatsu Kanai, Osamu Nureki

Strufcture, Function, and Dynamics International Conference (SFD Conference 2023)
膵臓がん及び胆管がん細胞に対するアミノ酸トランスポーターLAT1阻害薬nanvuranlatと細胞障害性抗がん薬の併用効果の検討

西窪航, 大垣隆一, 劉星明, 岡西広樹, 徐旻憓, 遠藤仁, 金井好克

第143回日本薬理学会近畿部会, Jun 24, 2023
Amino acid transporter LAT1 (SLC7A5) on cancer cell-derived exosomes as a potential prognostic- and diagnostic biomarker.

Dec 2, 2022
Inhibition of amino acid transporter LAT1 drastically suppresses the transport of large neutral amino acids and induces the downregulation of global translation in cancer cells

Nov 30, 2022
がん特異的アミノ酸トランスポーターLAT1 阻害薬JPH203 による胆道がん細胞内アミノ酸プールの破綻に伴うリン酸化プロテオーム解析

岡西広樹, 大垣隆一, Xu Minhui, 遠藤仁, 金井好克

第142回日本薬理学会近畿部会, Nov 12, 2022
Evaluation of LAT1 expression in patients with lung cancers and mediastinal tumors: [18F]FBPA PET study with immuno-histopathological comparison

T. Watabe, N. Ose, S. Naka, E. Fukui, T. Kanou, S. Funaki, H. Sasaki, T. Kamiya, K. Kurimoto, E. Shimosegawa, H. Kato, R. Ohgaki, Y. Kanai, Y. Shintani

EANM'22 - Annual Congress of the European Association of Nuclear Medicine, Oct 17, 2022
Roles of L-Type amino acid transporter1 in the development of intestinal tumors

Yunlong Sui, Namiko Hoshi, Ryuichi Ohgak, Yuki Ito, Takenori Kotani, Takashi Matozaki, Yuzo Kodama

30th United European Gastroenterology Week, Oct 11, 2022
Involvement of L-type amino acid transporter 1 in the development of intestinal tumors

Yunlong Sui, Namiko Hoshi, Ryuichi Ohgaki, Yuki Ito, Takenori Kotani, Takashi Matozaki, Yuzo Kodama

The 81st Annual Meeting of the Japanese Cancer Association, Oct 1, 2022
アミノ酸トランスポーターLAT1阻害薬が腫瘍細胞の大型中性アミノ酸輸送とタンパク質合成に与える影響

西窪航, 大垣隆一, 岡西広樹, 奥田傑, 徐旻憓, 遠藤仁, 金井好克

第141回日本薬理学会近畿部会, Jul 1, 2022
Contribution of LAT1 to amino acid uptake in cancer cells and suppression of cellular protein synthesis by LAT1 inhibitor

The 95th Annual Meeting of the Japanese Pharmacology Society, Mar 7, 2022
アミノ酸トランスポーターを標的としたがん治療の可能性：抗腫瘍効果の基盤となる多様な機序の存在

大垣隆一

第20回横断的腫瘍フォーラム, Jan 11, 2022
胆道がん細胞株におけるアミノ酸トランスポーターLAT1阻害薬が示す増殖抑制作用のタンパク質発現・リン酸化変動の網羅的解析による検討

岡西広樹, 大垣隆一, 奥田傑, 遠藤仁, 金井好克

第140回日本薬理学会近畿部会, Nov 13, 2021
血管内皮細胞におけるアミノ酸トランスポーターLAT1の発現亢進とVEGF-Aシグナルの制御による腫瘍血管新生への寄与

大垣隆一

第3回生命医科学若手研究者の会, Nov 12, 2021
アミノ酸トランスポーターLAT1阻害薬JPH203による胆道がん細胞増殖抑制機構に関わるプロテオミクスおよびリン酸化プロテオミクス解析

岡西広樹, 大垣隆一, 奥田傑, 遠藤仁, 金井好克

第94回日本生化学会大会, Nov 3, 2021
腫瘍血管新生におけるアミノ酸トランスポーターLAT1 の機能

大垣隆一

第1 回トランスポーター研究会関西部会, Oct 30, 2021 Invited
Suppression of proliferation of cholangiocarcinoma cells by miRNAs targeting L-type amino acid transporter 1 downregulated in cholangiocarcinomas

劉星明, 大垣隆一, 岡西広樹, 奥田傑, 徐旻恵, 金井好克

第139回日本薬理学会近畿部会, Jun 26, 2021

Teaching Experience

Professional Memberships

Major Research Projects

虚血性網膜症の器官培養系解析モデルの確立と新規治療法の提唱

令和2年度国立大学改革強化推進補助金（国立大学経営改革促進事業）「大阪大学の強みを活かした「知」と「人材」と「資金」の好循環システムの基盤構築」, 文部科学省, Oct, 2020 - Mar, 2021

大垣隆一, 福嶋葉子, 松本真司
Amino acid signaling in the downstream of endothelially expressed amino acid transporter LAT1 that contributes to tumor angiogenesis

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2021

Ohgaki Ryuichi
がん特異的アミノ酸輸送体を標的とした新規治療薬の研究開発

次世代がん医療創生研究事業２０１９年度応用研究タイプ事業内指定公募, 国立研究開発法人日本医療研究開発機構, 2019 - 2021

金井好克, 大垣隆一, 奥田傑, 岡西広樹, 徐旻恵
Molecular identification of amino acid sensor and its function in mTORC1 signaling pathway

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

Ohgaki Ryuichi, OKUDA SUGURU, NAGAMORI SHUSHI
Research and development of novel cancer therapeutics based on metabolic regulation targeting an amino acid transporter

2018
Lipid metabolism in stratum corneum essential for the maintenace of intercellular ceramides mediated by a novel transmembrane lipase

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2015

OHGAKI Ryuichi

Academic Activities

International Training Program (ITP) Symposium 2009 at Groningen“Toward Brain Circulation through Research-Based Educational Collaboration and Exchange with EU”

Other

Osaka University, Graduate School of Science (OU-GSS) Osaka University, Office for International Pla, Dec, 2009
ITP/ICI ECP symposium2009

Other

Graduate School of Science/Engineering Science, Office for International Planning Affair Board, Mar, 2009

Other

日本薬理学会薬理学エデュケーター

Jan, 2020 - Present

第0083号 2020年1月1日～2024年12月31日
Association of Next Generation Scientists in Japanese Pharmacological Society

May, 2018 - Present
大阪大学大学院医学系研究科附属共同研究実習センター運営委員

Apr, 2021 - Mar, 2023
大阪大学大学院医学系研究科動物実験施設運営委員

Apr, 2020 - Mar, 2023

第７号委員（「実験施設長が特に必要と認めた者」）
第95回日本薬理学会年会若手研究者キャリア形成支援プログラム WG代表

Mar, 2022

3月7日～3月9日於福岡国際会議場・福岡サンパレス
第93回日本薬理学会年会若手研究者キャリア形成支援プログラム WG代表

Mar, 2020

2020年3月16日～18日於パシフィコ横浜 ※新型コロナウイルス感染症拡大により紙上開催
第92回日本薬理学会年会若手研究者キャリア形成支援プログラム WG代表

Mar, 2019

3月14日於大阪、大阪国際会議場
第92回日本薬理学会年会実行委員

Mar, 2019

3月14～16日於大阪、大阪国際会議場
第132回日本薬理学会近畿部会事務局長

Nov, 2017

11月24日於大阪、千里ライフサイエンスセンター

Profile Information

Research Interests

Research Areas

Research History

Education

Committee Memberships

Awards

Papers

Misc.

Presentations

Teaching Experience

Professional Memberships

Major Research Projects

Academic Activities

Other

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