Papers

Peer-reviewed International journal
Dec 7, 2018

Unripe peach (Prunus persica) extract ameliorates damage from UV irradiation and improved collagen XVIII expression in 3D skin model.

Journal of cosmetic dermatology
  • Tomoko Yonezawa
  • ,
  • Ryusuke Momota
  • ,
  • Hideki Iwano
  • ,
  • Steven Zhao
  • ,
  • Tomohiro Hakozaki
  • ,
  • Chieko Soh
  • ,
  • Shigetoyo Sawaki
  • ,
  • Kazumi Toyama
  • ,
  • Toshitaka Oohashi

Language
English
Publishing type
Research paper (scientific journal)
DOI
10.1111/jocd.12841

INTRODUCTION: Collagen type XVIII regulates cellular activities of adjacent cells at the dermal-epidermal junction (DEJ). To investigate its possible changes during aging, we compared its mRNA levels and protein localization in skin samples from female participants aged 20-70 years old. In addition, we evaluated the beneficial effects of unripe peach extracts in a 3D skin model. METHODS: Sun-exposed or sun-protected female skin samples were compared by DNA array or by immunohistochemistry for basement membrane components. To evaluate protective effects of fresh unripe peach extract, UV-B irradiated human 3D skin models were incubated in the presence or absence of the extract, followed by measurements of mRNA levels by real-time PCR, or by immunohistochemistry. RESULTS: In aged skin samples, COL18A1 mRNA levels were lower and the protein localization exhibited less intensive signal by anti-collagen type XVIII immunostaining. As observed in the skin tissues, collagen type XVIII exists at the DEJ in the 3D skin model. Fresh unripe peach extract significantly improved mRNA levels and partially localizations of collagen type XVIII, suggesting that fresh unripe peach extract ameliorates DEJ damages caused by UV-B irradiation. CONCLUSION: Collagen type XVIII and fresh unripe peach extract can be promising protective cosmetic strategies against skin aging.

Link information
DOI
https://doi.org/10.1111/jocd.12841
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/30548159
URL
http://orcid.org/0000-0002-7003-3444
ID information
  • DOI : 10.1111/jocd.12841
  • ISSN : 1473-2130
  • ORCID - Put Code : 51450032
  • Pubmed ID : 30548159

Export
BibTeX RIS