Papers

Peer-reviewed
2012

Abnormalities in the Fiber Composition and Capillary Architecture in the Soleus Muscle of Type 2 Diabetic Goto-Kakizaki Rats

SCIENTIFIC WORLD JOURNAL
  • Shinichiro Murakami
  • ,
  • Naoto Fujita
  • ,
  • Hiroyo Kondo
  • ,
  • Isao Takeda
  • ,
  • Ryusuke Momota
  • ,
  • Aiji Ohtsuka
  • ,
  • Hidemi Fujino

Volume
2012
Number
First page
680189
Last page
Language
English
Publishing type
Research paper (scientific journal)
DOI
10.1100/2012/680189
Publisher
HINDAWI PUBLISHING CORPORATION

Type 2 diabetes mellitus is linked to impaired skeletal muscle glucose uptake and storage. This study aimed to investigate the fiber type distributions and the three-dimensional (3D) architecture of the capillary network in the skeletal muscles of type 2 diabetic rats. Muscle fiber type transformation, succinate dehydrogenase (SDH) activity, capillary density, and 3D architecture of the capillary network in the soleus muscle were determined in 36-week-old Goto-Kakizaki (GK) rats as an animal model of nonobese type 2 diabetes and age-matched Wistar (Cont) rats. Although the soleus muscle of Cont rats comprised both type I and type IIA fibers, the soleus muscle of GK rats had only type I fibers. In addition, total SDH activity in the soleus muscle of GK rats was significantly lower than that in Cont rats because GK rats had no high-SDH activity type IIA fiber in the soleus muscle. Furthermore, the capillary diameter, capillary tortuosity, and microvessel volume in GK rats were significantly lower than those in Cont rats. These results indicate that non-obese diabetic GK rats have muscle fiber type transformation, low SDH activity, and reduced skeletal muscle capillary content, which may be related to the impaired glucose metabolism characteristic of type 2 diabetes.


Link information
DOI
https://doi.org/10.1100/2012/680189
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/23213294
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000311211000001&DestApp=WOS_CPL
URL
http://orcid.org/0000-0002-7003-3444
ID information
  • DOI : 10.1100/2012/680189
  • ISSN : 1537-744X
  • ORCID - Put Code : 9101208
  • Pubmed ID : 23213294
  • Web of Science ID : WOS:000311211000001

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