Papers

Peer-reviewed International journal
May, 2011

Drosophila type XV/XVIII collagen, Mp, is involved in Wingless distribution

MATRIX BIOLOGY
  • Ryusuke Momota
  • ,
  • Ichiro Naito
  • ,
  • Yoshifumi Ninomiya
  • ,
  • Aiji Ohtsuka

Volume
30
Number
4
First page
258
Last page
266
Language
English
Publishing type
Research paper (scientific journal)
DOI
10.1016/j.matbio.2011.03.008
Publisher
ELSEVIER SCIENCE BV

Multiplexin (Mp) is the Drosophila orthologue of vertebrate collagens XV and XVIII. Like them, Mp is widely distributed in the basement membranes of the developing embryos, including those of neuroblasts in the central and peripheral nervous systems, visceral muscles of the gut, and contractile cardioblasts. Here we report the identification of mutant larvae bearing piguBac transposon insertions that exhibit decrease Mp production associated with abdominal cuticular and wing margin defects, malformation of sensory organs and impaired sensitivity to physical stimuli. Additional findings include the abnormal ultrastructure of fatbody associated with abnormal collagen IV deposition, and reduced Wingless deposition. Collectively, these findings are consistent with the notion that Mp is required for the proper formation and/or maintenance of basement membrane, and that Mp may be involved in establishing the Wingless signaling gradients in the Drosophila embryo. (C) 2011 Elsevier B.V. All rights reserved.


Link information
DOI
https://doi.org/10.1016/j.matbio.2011.03.008
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/21477650
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000292677400004&DestApp=WOS_CPL
URL
http://orcid.org/0000-0002-7003-3444
ID information
  • DOI : 10.1016/j.matbio.2011.03.008
  • ISSN : 0945-053X
  • ORCID - Put Code : 9101209
  • Pubmed ID : 21477650
  • Web of Science ID : WOS:000292677400004

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