Papers

Peer-reviewed
Nov, 2008

Type IV collagen alpha chains of the basement membrane in the rat bronchioalveolar transitional segment

ARCHIVES OF HISTOLOGY AND CYTOLOGY
  • Noriko Hinenoya
  • ,
  • Ichiro Naito
  • ,
  • Ryusuke Momota
  • ,
  • Yoshikazu Sado
  • ,
  • Kanae Kumagishi
  • ,
  • Yoshifumi Ninomiya
  • ,
  • Aiji Ohtsuka

Volume
71
Number
3
First page
185
Last page
194
Language
English
Publishing type
Research paper (scientific journal)
DOI
10.1679/aohc.71.185
Publisher
INT SOC HISTOLOGY & CYTOLOGY

In the present study, we have analyzed the a(IV) chain distribution in the subepithelial basement membrane (BM) of the rat pulmonary airway from the bronchi to alveoli. We have furthermore analyzed the a(IV) chain distribution in the subepithelial BM of the bronchioalveolar duct junction (BADJ) using a(IV) chain specific monoclonal antibodies. Our results show that the BM of the bronchial and bronchiolar epithelium contains [al(IV)](2) a2(IV) and [ a5(IV)](2) a6(IV) molecules and confirmed that the alveolar BM consists of [a1(IV)](2) a2(IV) and a3(IV) a4(IV) a5(IV) molecules. There are also small regions in BADJ consisting of only [ a] (IV)](2) a2(IV) molecules without a3(IV) a4(IV) a5(IV) and [ a5(IV)](2) a6(IV) molecules. Moreover, the bronchioalveolar stem cells (BASCs) -primordial cells for bronchiolar Clara cells and alveolar type II (AT2) cells- lie adjacent to such small regions. These findings suggest that [ al(IV)](2) a2(IV) may be important for the BASCs to self-renew or to self-maintain themselves and that microenvironments produced by a(IV) chains may be important for cell differentiation.


Link information
DOI
https://doi.org/10.1679/aohc.71.185
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/19194041
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000262955100005&DestApp=WOS_CPL
URL
http://orcid.org/0000-0002-7003-3444
ID information
  • DOI : 10.1679/aohc.71.185
  • ISSN : 0914-9465
  • eISSN : 1349-1717
  • ORCID - Put Code : 9101212
  • Pubmed ID : 19194041
  • Web of Science ID : WOS:000262955100005

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