ryuuichi shigemoto - My portal

Profile Information

Affiliation: -

Degree: PhD

J-GLOBAL ID: 201101094528468790
researchmap Member ID: B000001744

External link: http://ist.ac.at/research/life-sciences/shigemoto-group/

Research Interests

Research Areas

Research History

Mar, 2013 - Present

Fukuoka Industry Scienece & Technology Foundation
2004 - Feb, 2013

Department of Cerebral Research, National Institute for Physiological Sciences
2001 - 2003

教授, 岡崎国立共同研究機構生理学研究所
2000

教授, 岡崎国立共同研究機構福井県立大学・生理学研究所・脳形態解析部門
1999

助手・教授, 京都大学岡崎国立共同研究機構・医学（系）研究科・生理学研究所・脳形態解析部門
1998

助手, 京都大学医学（系）研究科・医学研究科
1990 - 1994

Faculty of Medicine, Kyoto University

Papers

Immunolocalization of multiple membrane proteins on a carbon replica with STEM and EDX

Alexandre Loukanov, Naomi Kamasawa, Radostin Danev, Ryuichi Shigemoto, Kuniaki Nagayama

ULTRAMICROSCOPY, 110(4) 366-374, Mar, 2010 Peer-reviewed
Disruption of LGI1-linked synaptic complex causes abnormal synaptic transmission and epilepsy

Yuko Fukata, Kathryn L. Lovero, Tsuyoshi Iwanaga, Atsushi Watanabe, Norihiko Yokoi, Katsuhiko Tabuchi, Ryuichi Shigemoto, Roger A. Nicoll, Masaki Fukata

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 107(8) 3799-3804, Feb, 2010 Peer-reviewed
Tuning of the Zernike phase-plate for visualization of detailed ultrastructure in complex biological specimens

Yoshiyuki Fukuda, Yugo Fukazawa, Radostin Danev, Ryuichi Shigemoto, Kuniaki Nagayama

JOURNAL OF STRUCTURAL BIOLOGY, 168(3) 476-484, Dec, 2009 Peer-reviewed
Visual Properties of Transgenic Rats Harboring the Channelrhodopsin-2 Gene Regulated by the Thy-1.2 Promoter

Hiroshi Tomita, Eriko Sugano, Yugo Fukazawa, Hitomi Isago, Yuka Sugiyama, Teru Hiroi, Toru Ishizuka, Hajime Mushiake, Megumi Kato, Masumi Hirabayashi …

PLOS ONE, 4(11) e7679, Nov, 2009 Peer-reviewed
Fluorescent Arc/Arg3.1 indicator mice: A versatile tool to study brain activity changes in vitro and in vivo

Valery Grinevich, Alexander Kolleker, Marina Eliava, Naoki Takada, Hiroshi Takuma, Yugo Fukazawa, Ryuichi Shigemoto, Dietmar Kuhl, Jack Waters, Peter H. Seeburg …

JOURNAL OF NEUROSCIENCE METHODS, 184(1) 25-36, Oct, 2009 Peer-reviewed
Input-Specific Intrasynaptic Arrangements of Ionotropic Glutamate Receptors and Their Impact on Postsynaptic Responses

Etsuko Tarusawa, Ko Matsui, Timotheus Budisantoso, Elek Molnar, Masahiko Watanabe, Minoru Matsui, Yugo Fukazawa, Ryuichi Shigemoto

JOURNAL OF NEUROSCIENCE, 29(41) 12896-12908, Oct, 2009 Peer-reviewed
Subcellular compartment-specific molecular diversity of pre- and post-synaptic GABA(B)-activated GIRK channels in Purkinje cells

Laura Fernandez-Alacid, Carolina Aguado, Francisco Ciruela, Ricardo Martin, Jose Colon, Maria Jose Cabanero, Martin Gassmann, Masahiko Watanabe, Ryuichi Shigemoto, Kevin Wickman …

JOURNAL OF NEUROCHEMISTRY, 110(4) 1363-1376, Aug, 2009 Peer-reviewed
Crosstalk between GABA(B) and mGlu1a receptors reveals new insight into GPCR signal integration

Marie-Laure Rives, Claire Vol, Yugo Fukazawa, Norbert Tinel, Eric Trinquet, Mohammed Akli Ayoub, Ryuichi Shigemoto, Jean-Philippe Pin, Laurent Prezeau

EMBO JOURNAL, 28(15) 2195-2208, Aug, 2009 Peer-reviewed
Large-Conductance Calcium-Activated Potassium Channels in Purkinje Cell Plasma Membranes Are Clustered at Sites of Hypolemmal Microdomains

Walter A. Kaufmann, Francesco Ferraguti, Yugo Fukazawa, Yu Kasugai, Ryuichi Shigemoto, Petter Laake, Joseph A. Sexton, Peter Ruth, Georg Wietzorrek, Hans-Guenther Knaus …

JOURNAL OF COMPARATIVE NEUROLOGY, 515(2) 215-230, Jul, 2009 Peer-reviewed
Mice with Altered Myelin Proteolipid Protein Gene Expression Display Cognitive Deficits Accompanied by Abnormal Neuron-Glia Interactions and Decreased Conduction Velocities

Hisataka Tanaka, Jianmei Ma, Kenji F. Tanaka, Keizo Takao, Munekazu Komada, Koichi Tanda, Ayaka Suzuki, Tomoko Ishibashi, Hiroko Baba, Tadashi Isa …

JOURNAL OF NEUROSCIENCE, 29(26) 8363-8371, Jul, 2009 Peer-reviewed
Selective Gating of Glutamatergic Inputs to Excitatory Neurons of Amygdala by Presynaptic GABAb Receptor

Bing-Xing Pan, Yulin Dong, Wataru Ito, Yuchio Yanagawa, Ryuichi Shigemoto, Alexei Morozov

NEURON, 61(6) 917-929, Mar, 2009 Peer-reviewed
The GABA(B1a) Isoform Mediates Heterosynaptic Depression at Hippocampal Mossy Fiber Synapses

Nicole Guetg, Riad Seddik, Rejan Vigot, Rostislav Turecek, Martin Gassmann, Kaspar E. Vogt, Hans Braeuner-Osborne, Ryuichi Shigemoto, Oliver Kretz, Michael Frotscher …

JOURNAL OF NEUROSCIENCE, 29(5) 1414-1423, Feb, 2009 Peer-reviewed
Left-right asymmetry of the hippocampal synapses with differential subunit allocation of glutamate receptors

Yoshiaki Shinohara, Hajime Hirase, Masahiko Watanabe, Makoto Itakura, Masami Takahashi, Ryuichi Shigemoto

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 105(49) 19498-19503, Dec, 2008 Peer-reviewed
Numbers, densities, and colocalization of AMPA- and NMDA-type glutamate receptors at individual synapses in the superficial spinal dorsal horn of rats

Miklos Antal, Yugo Fukazawa, Maria Eordogh, Dora Muszil, Elek Molnar, Makoto Itakura, Masami Takahashi, Ryuichi Shigemoto

JOURNAL OF NEUROSCIENCE, 28(39) 9692-9701, Sep, 2008 Peer-reviewed
Connexin45-containing neuronal gap junctions in rodent retina also contain connexin36 in both apposing hemiplaques, forming bihomotypic gap junctions, with scaffolding contributed by zonula occludens-1

Xinbo Li, Naomi Kamasawa, Cristina Ciolofan, Carl O. Olson, Shijun Lu, Kimberly G. V. Davidson, Thomas Yasumura, Ryuichi Shigemoto, John E. Rash, James I. Nagy

JOURNAL OF NEUROSCIENCE, 28(39) 9769-9789, Sep, 2008 Peer-reviewed
The presence of pacemaker HCN channels identifies theta rhythmic GABAergic neurons in the medial septum

Viktor Varga, Balazs Hangya, Kinga Kranitz, Aniko Ludanyi, Rita Zemankovics, Istvan Katona, Ryuichi Shigemoto, Tamas F. Freund, Zsolt Borhegyi

JOURNAL OF PHYSIOLOGY-LONDON, 586(16) 3893-3915, Aug, 2008 Peer-reviewed
Dendritic I-h ensures high-fidelity dendritic spike responses of motion-sensitive neurons in rat superior colliculus

Toshiaki Endo, Etsuko Tarusawa, Takuya Notomi, Katsuyuki Kaneda, Masumi Hirabayashi, Ryuichi Shigemoto, Tadashi Isa

JOURNAL OF NEUROPHYSIOLOGY, 99(5) 2066-2076, May, 2008 Peer-reviewed
Increased social interaction in mice deficient of the striatal medium spiny neuron-specific phosphodiesterase 10A2

Hiromi Sano, Yumiko Nagai, Tsuyoshi Miyakawa, Ryuichi Shigemoto, Mineto Ykoi

JOURNAL OF NEUROCHEMISTRY, 105(2) 546-556, Apr, 2008 Peer-reviewed
Right Isomerism of the Brain in Inversus Viscerum Mutant Mice

Ryosuke Kawakami, Alice Dobi, Ryuichi Shigemoto, Isao Ito

PLOS ONE, 3(4) e1945, Apr, 2008 Peer-reviewed
The coexistence of multiple receptors in a single nerve terminal provides evidence for pre-synaptic integration

Carolina Ladera, Maria del Carmen Godino, Ricardo Martin, Rafael Lujan, Ryuichi Shigemoto, Francisco Ciruela, Magdalena Torres, Jose Sanchez-Prieto

JOURNAL OF NEUROCHEMISTRY, 103(6) 2314-2326, Dec, 2007 Peer-reviewed

Misc.

膜分子をみる : 凍結割断レプリカ免疫標識法(2. 免疫組織細胞化学法の実際, III. 遺伝子・分子をみる)

重本隆一

組織細胞化学, 2005 67-72, Jul 10, 2005
幼弱プルキンエ細胞におけるAMPA型グルタミン酸受容体の数と密度

Journal of Neuroscience, 25, 799-807, 2005
海馬NMDA受容体NR2Bサブユニットの左右非対称性配置

Science, 300, 990-994, 2003
ホジキン病患者に認められた代謝調節型グルタミン酸受容体mGluR1の自己抗体はmGluR1の活性化を阻害し小脳失調を引き起こす

New England Journal of Medicine, 342, 21-7, 2000
GABA(B)-receptor subtypes assemble into functional heteromeric complexes

K Kaupmann, B Malitschek, Schuler, V, J Heid, W Froest, P Beck, J Mosbacher, S Bischoff, A Kulik, R Shigemoto …

NATURE, 396(6712) 683-687, Dec, 1998
ガンマアミノ酪酸受容体(GABAB)のサブタイプは集合して機能的な複合体を形成する

Nature, 396 683, 1998
Differential Presynaptic Localization of Metabotropic Glutamate Receptor Subtypes in the Rat Hippocampus

The Journal of Neuroscience, 17 19, 1997
シナプス前性メタボトロピックグルタミン酸受容体サブタイプのラット海馬における特異的局在

Journal of Neuroscience, 17 19, 1997
Target-cell-specific concentration of a metabotropic glutamate receptor In the presynaptic active zone

R Shigemoto, A Kulik, JDB Roberts, H Ohishi, Z Nusser, T Kaneko, P Somogyi

NATURE, 381(6582) 523-525, Jun, 1996
メタボトロピックグルタミン酸受容体の前シナプス活動部位における標的細胞特異的濃縮

Nature, 381 523, 1996
ANTIBODIES INACTIVATING MGLUR1 METABOTROPIC GLUTAMATE-RECEPTOR BLOCK LONG-TERM DEPRESSION IN CULTURED PURKINJE-CELLS

R SHIGEMOTO, T ABE, S NOMURA, S NAKANISHI, T HIRANO

NEURON, 12(6) 1245-1255, Jun, 1994
DEVELOPMENTALLY-REGULATED POSTSYNAPTIC LOCALIZATION OF A METABOTROPIC GLUTAMATE-RECEPTOR IN RAT ROD BIPOLAR CELLS

A NOMURA, R SHIGEMOTO, Y NAKAMURA, N OKAMOTO, N MIZUNO, S NAKANISHI

CELL, 77(3) 361-369, May, 1994
メタボトロピックグルタミン酸受容体mGluR1を阻害する抗体は培養プルキンエ細胞において長期抑圧現象を抑制する

Neuron, 12 1245, 1994
メタボトロピックグルタミン酸受容体のラット細膜双極細胞における発生による局在の制御

Cell, 77 361, 1994
Expression of the mRNA for the rat NMDA receptor (NMDARI) in the sensory and autonomic ganglion neurons

Neuroscience Letters, 144, 1992
Distribution of the mRNA for a metabotropic Glutamate receptor (mGIuRI) in the central Neruous system : An in situ nybridization study in abult and developing rat

The Journal of Comparative Neurology, 322 121, 1992
Cloning and Expression of a Rat Neuromedin K Receptor ┣D2C┫D2DNA

The Journal of Bidogical Chemistry, 265 2, 1990

Research Projects

記憶の脳内表現と長期定着のメカニズム

ＪＳＴ戦略的創造研究推進制度（研究チーム型）（戦略的基礎研究推進事業：ＣＲＥＳＴ）, 2004 - 2009
海馬シナプスの左右差
神経機能阻害抗体と傍腫瘍性神経症候群
細胞膜上機能分子の動態と神経伝達調節機構
Anti-neural antibodies and paraneoplastic syndrome
Dynamic localization of functional membrane molecules and mechanism of neurotransmission.
Localization and Function of Glutamate and GABA receptors
グルタミン酸受容体及びGABA受容体の局在と機能